Face transplantation: on the verge of becoming clinical routine?
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Face transplantation: on the verge of becoming clinical routine? / Smeets, Ralf; Rendenbach, Carsten; Birkelbach, Moritz; Al-Dam, Ahmed; Gröbe, Alexander; Hanken, Henning; Heiland, Max.
In: BIOMED RES INT, Vol. 2014, 2014, p. 907272.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Face transplantation: on the verge of becoming clinical routine?
AU - Smeets, Ralf
AU - Rendenbach, Carsten
AU - Birkelbach, Moritz
AU - Al-Dam, Ahmed
AU - Gröbe, Alexander
AU - Hanken, Henning
AU - Heiland, Max
PY - 2014
Y1 - 2014
N2 - UNLABELLED: INTRODUCTION; Face transplantation (FT) is an innovative achievement of modern reconstructive surgery and is on the verge of becoming a common surgical opportunity. This review article was compiled to provide an update on this surgical field, especially regarding clinical outcomes, benefits, and complications implied.METHODS: We performed an extensive research on all English-language Medline articles, case reports, and reviews published online until September 15, 2013. Used search terms were "face transplantation," "face transplant," "facial transplantation," "facial transplant," "face allograft," and "facial allograft."RESULTS: To date 27 FTs have been performed worldwide. 19 of these cases have been published in the Medline database. Long-term follow-up reports of FT cases are rare. Three deaths associated with the procedure have occurred to date. The clinical outcomes of FT are satisfying. Reinnervation of sensation has been faster than motor recovery. Extensive functional improvements have been observed. Due to strict immunosuppression protocols, no case of hyperacute or chronic rejection and no graft-versus-host disease have occurred to date.CONCLUSIONS: As studies on long-term outcomes are missing, particularly regarding immunosuppression-related complications, FT will stay experimental for the next years. Nevertheless, for a small group of patients, FT already is a feasible reconstructive option.
AB - UNLABELLED: INTRODUCTION; Face transplantation (FT) is an innovative achievement of modern reconstructive surgery and is on the verge of becoming a common surgical opportunity. This review article was compiled to provide an update on this surgical field, especially regarding clinical outcomes, benefits, and complications implied.METHODS: We performed an extensive research on all English-language Medline articles, case reports, and reviews published online until September 15, 2013. Used search terms were "face transplantation," "face transplant," "facial transplantation," "facial transplant," "face allograft," and "facial allograft."RESULTS: To date 27 FTs have been performed worldwide. 19 of these cases have been published in the Medline database. Long-term follow-up reports of FT cases are rare. Three deaths associated with the procedure have occurred to date. The clinical outcomes of FT are satisfying. Reinnervation of sensation has been faster than motor recovery. Extensive functional improvements have been observed. Due to strict immunosuppression protocols, no case of hyperacute or chronic rejection and no graft-versus-host disease have occurred to date.CONCLUSIONS: As studies on long-term outcomes are missing, particularly regarding immunosuppression-related complications, FT will stay experimental for the next years. Nevertheless, for a small group of patients, FT already is a feasible reconstructive option.
KW - Allografts
KW - Facial Transplantation
KW - Humans
KW - Immunosuppression
KW - MEDLINE
U2 - 10.1155/2014/907272
DO - 10.1155/2014/907272
M3 - SCORING: Journal article
C2 - 25009821
VL - 2014
SP - 907272
JO - BIOMED RES INT
JF - BIOMED RES INT
SN - 2314-6133
ER -
