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Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning.

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Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning. / Hart, Melanie L; Much, Chressen; Gorzolla, Iris C; Schittenhelm, Jens; Kloor, Doris; Stahl, Gregory L; Eltzschig, Holger K.

In: GASTROENTEROLOGY, Vol. 135, No. 5, 5, 2008, p. 1733-1739.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hart, ML, Much, C, Gorzolla, IC, Schittenhelm, J, Kloor, D, Stahl, GL & Eltzschig, HK 2008, 'Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning.', GASTROENTEROLOGY, vol. 135, no. 5, 5, pp. 1733-1739. <http://www.ncbi.nlm.nih.gov/pubmed/18804111?dopt=Citation>

APA

Hart, M. L., Much, C., Gorzolla, I. C., Schittenhelm, J., Kloor, D., Stahl, G. L., & Eltzschig, H. K. (2008). Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning. GASTROENTEROLOGY, 135(5), 1733-1739. [5]. http://www.ncbi.nlm.nih.gov/pubmed/18804111?dopt=Citation

Vancouver

Hart ML, Much C, Gorzolla IC, Schittenhelm J, Kloor D, Stahl GL et al. Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning. GASTROENTEROLOGY. 2008;135(5):1733-1739. 5.

Bibtex

@article{609517e359fa43d4a7b4b50f9a4c46cb,
title = "Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning.",
abstract = "The liver tolerates ischemia/reperfusion (IR) poorly. The discovery of ischemic preconditioning (IP) has raised hopes that natural pathways could be activated to increase hepatic resistance to ischemia. However, mechanisms of hepatic IP remain largely unknown. Extracellular adenosine has been implicated as an innate anti-inflammatory metabolite, particularly during ischemia. We investigated whether ecto-5'-nucleotidase (CD73), the {"}pacemaker{"} enzyme of extracellular adenosine production, is critical for hepatic protection by IP.",
author = "Hart, {Melanie L} and Chressen Much and Gorzolla, {Iris C} and Jens Schittenhelm and Doris Kloor and Stahl, {Gregory L} and Eltzschig, {Holger K}",
year = "2008",
language = "Deutsch",
volume = "135",
pages = "1733--1739",
journal = "GASTROENTEROLOGY",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning.

AU - Hart, Melanie L

AU - Much, Chressen

AU - Gorzolla, Iris C

AU - Schittenhelm, Jens

AU - Kloor, Doris

AU - Stahl, Gregory L

AU - Eltzschig, Holger K

PY - 2008

Y1 - 2008

N2 - The liver tolerates ischemia/reperfusion (IR) poorly. The discovery of ischemic preconditioning (IP) has raised hopes that natural pathways could be activated to increase hepatic resistance to ischemia. However, mechanisms of hepatic IP remain largely unknown. Extracellular adenosine has been implicated as an innate anti-inflammatory metabolite, particularly during ischemia. We investigated whether ecto-5'-nucleotidase (CD73), the "pacemaker" enzyme of extracellular adenosine production, is critical for hepatic protection by IP.

AB - The liver tolerates ischemia/reperfusion (IR) poorly. The discovery of ischemic preconditioning (IP) has raised hopes that natural pathways could be activated to increase hepatic resistance to ischemia. However, mechanisms of hepatic IP remain largely unknown. Extracellular adenosine has been implicated as an innate anti-inflammatory metabolite, particularly during ischemia. We investigated whether ecto-5'-nucleotidase (CD73), the "pacemaker" enzyme of extracellular adenosine production, is critical for hepatic protection by IP.

M3 - SCORING: Zeitschriftenaufsatz

VL - 135

SP - 1733

EP - 1739

JO - GASTROENTEROLOGY

JF - GASTROENTEROLOGY

SN - 0016-5085

IS - 5

M1 - 5

ER -