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Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma

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Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma. / Friedrich, Reinhard E; Hagel, Christian; Zustin, Jozef.

In: ANTICANCER RES, Vol. 36, No. 6, 06.2016, p. 3103-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Friedrich, RE, Hagel, C & Zustin, J 2016, 'Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma', ANTICANCER RES, vol. 36, no. 6, pp. 3103-7.

APA

Friedrich, R. E., Hagel, C., & Zustin, J. (2016). Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma. ANTICANCER RES, 36(6), 3103-7.

Vancouver

Friedrich RE, Hagel C, Zustin J. Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma. ANTICANCER RES. 2016 Jun;36(6):3103-7.

Bibtex

@article{dfbde851a2544fe7b112eadc072eb5e0,
title = "Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma",
abstract = "UNLABELLED: Odontogenic myxoma (OM) is a rare mesenchymal tumour arising in the jaws. The origin and pathogenesis of OM is poorly understood. The aim of this study was to characterize OM by immunolocalization of certain antigens in the tumour that are relevant for cellular differentiation, migration and maintenance.MATERIALS AND METHODS: Five OMs were immunohistochemically investigated for expression of nestin, CD133, podoplanin, and insulin-like growth factor 1 receptor (IGF-1R).RESULTS: OM failed to react with antibodies applied in this study, with the exception of IGF-1R in tumour cells.DISCUSSION: OM is a poorly characterized benign, invasive tumour of the jaws. The absence of stem cell marker in OM does not exclude possible temporary expression of these antigens during certain phases of tumour development. The identification of IGF-1R in OM is shared with numerous tumours and indicates the ability of these tumour cells to respond to growth factors.",
author = "Friedrich, {Reinhard E} and Christian Hagel and Jozef Zustin",
note = "Copyright{\textcopyright} 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.",
year = "2016",
month = jun,
language = "English",
volume = "36",
pages = "3103--7",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "6",

}

RIS

TY - JOUR

T1 - Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma

AU - Friedrich, Reinhard E

AU - Hagel, Christian

AU - Zustin, Jozef

N1 - Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

PY - 2016/6

Y1 - 2016/6

N2 - UNLABELLED: Odontogenic myxoma (OM) is a rare mesenchymal tumour arising in the jaws. The origin and pathogenesis of OM is poorly understood. The aim of this study was to characterize OM by immunolocalization of certain antigens in the tumour that are relevant for cellular differentiation, migration and maintenance.MATERIALS AND METHODS: Five OMs were immunohistochemically investigated for expression of nestin, CD133, podoplanin, and insulin-like growth factor 1 receptor (IGF-1R).RESULTS: OM failed to react with antibodies applied in this study, with the exception of IGF-1R in tumour cells.DISCUSSION: OM is a poorly characterized benign, invasive tumour of the jaws. The absence of stem cell marker in OM does not exclude possible temporary expression of these antigens during certain phases of tumour development. The identification of IGF-1R in OM is shared with numerous tumours and indicates the ability of these tumour cells to respond to growth factors.

AB - UNLABELLED: Odontogenic myxoma (OM) is a rare mesenchymal tumour arising in the jaws. The origin and pathogenesis of OM is poorly understood. The aim of this study was to characterize OM by immunolocalization of certain antigens in the tumour that are relevant for cellular differentiation, migration and maintenance.MATERIALS AND METHODS: Five OMs were immunohistochemically investigated for expression of nestin, CD133, podoplanin, and insulin-like growth factor 1 receptor (IGF-1R).RESULTS: OM failed to react with antibodies applied in this study, with the exception of IGF-1R in tumour cells.DISCUSSION: OM is a poorly characterized benign, invasive tumour of the jaws. The absence of stem cell marker in OM does not exclude possible temporary expression of these antigens during certain phases of tumour development. The identification of IGF-1R in OM is shared with numerous tumours and indicates the ability of these tumour cells to respond to growth factors.

M3 - SCORING: Journal article

C2 - 27272834

VL - 36

SP - 3103

EP - 3107

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 6

ER -