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Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome.

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Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome. / Kempkensteffen, Carsten; Hinz, Stefan; Christoph, Frank; Krause, Hans; Köllermann, Jens; Magheli, Ahmed; Schrader, Mark; Schostak, Martin; Miller, Kurt; Weikert, Steffen.

In: TUMOR BIOL, Vol. 28, No. 3, 3, 2007, p. 132-138.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kempkensteffen, C, Hinz, S, Christoph, F, Krause, H, Köllermann, J, Magheli, A, Schrader, M, Schostak, M, Miller, K & Weikert, S 2007, 'Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome.', TUMOR BIOL, vol. 28, no. 3, 3, pp. 132-138. <http://www.ncbi.nlm.nih.gov/pubmed/17519534?dopt=Citation>

APA

Kempkensteffen, C., Hinz, S., Christoph, F., Krause, H., Köllermann, J., Magheli, A., Schrader, M., Schostak, M., Miller, K., & Weikert, S. (2007). Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome. TUMOR BIOL, 28(3), 132-138. [3]. http://www.ncbi.nlm.nih.gov/pubmed/17519534?dopt=Citation

Vancouver

Kempkensteffen C, Hinz S, Christoph F, Krause H, Köllermann J, Magheli A et al. Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome. TUMOR BIOL. 2007;28(3):132-138. 3.

Bibtex

@article{ee3304d72ccd4570886bc27e81ef3691,
title = "Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome.",
abstract = "Livin has recently been identified as a member of the inhibitor of apoptosis family expressed in several types of cancer but not in most benign tissues. Expression levels of livin were associated with prognosis in various malignancies, but livin expression and its prognostic relevance have not been evaluated in renal cell carcinomas (RCC). In a cohort of 152 RCC patients, we analyzed the relative expression of livin and its splicing variants by real-time RT-PCR and Western blot in tumor and adjacent normal renal tissue specimens. Livin expression was detected in 59 (38.8%) of 152 RCC specimens but in none of the normal samples. Both splicing variants were present in the livin-positive RCC specimens. Livin expression levels did not correlate with pathological or clinical parameters and were not predictive of patient outcome. Our findings suggest that livin expression in RCC is not of prognostic relevance. Further studies to clarify the role of livin expression in RCC and its potential value as a target for immune-mediated tumor destruction are warranted.",
author = "Carsten Kempkensteffen and Stefan Hinz and Frank Christoph and Hans Krause and Jens K{\"o}llermann and Ahmed Magheli and Mark Schrader and Martin Schostak and Kurt Miller and Steffen Weikert",
year = "2007",
language = "Deutsch",
volume = "28",
pages = "132--138",
journal = "TUMOR BIOL",
issn = "1010-4283",
publisher = "Springer Netherlands",
number = "3",

}

RIS

TY - JOUR

T1 - Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome.

AU - Kempkensteffen, Carsten

AU - Hinz, Stefan

AU - Christoph, Frank

AU - Krause, Hans

AU - Köllermann, Jens

AU - Magheli, Ahmed

AU - Schrader, Mark

AU - Schostak, Martin

AU - Miller, Kurt

AU - Weikert, Steffen

PY - 2007

Y1 - 2007

N2 - Livin has recently been identified as a member of the inhibitor of apoptosis family expressed in several types of cancer but not in most benign tissues. Expression levels of livin were associated with prognosis in various malignancies, but livin expression and its prognostic relevance have not been evaluated in renal cell carcinomas (RCC). In a cohort of 152 RCC patients, we analyzed the relative expression of livin and its splicing variants by real-time RT-PCR and Western blot in tumor and adjacent normal renal tissue specimens. Livin expression was detected in 59 (38.8%) of 152 RCC specimens but in none of the normal samples. Both splicing variants were present in the livin-positive RCC specimens. Livin expression levels did not correlate with pathological or clinical parameters and were not predictive of patient outcome. Our findings suggest that livin expression in RCC is not of prognostic relevance. Further studies to clarify the role of livin expression in RCC and its potential value as a target for immune-mediated tumor destruction are warranted.

AB - Livin has recently been identified as a member of the inhibitor of apoptosis family expressed in several types of cancer but not in most benign tissues. Expression levels of livin were associated with prognosis in various malignancies, but livin expression and its prognostic relevance have not been evaluated in renal cell carcinomas (RCC). In a cohort of 152 RCC patients, we analyzed the relative expression of livin and its splicing variants by real-time RT-PCR and Western blot in tumor and adjacent normal renal tissue specimens. Livin expression was detected in 59 (38.8%) of 152 RCC specimens but in none of the normal samples. Both splicing variants were present in the livin-positive RCC specimens. Livin expression levels did not correlate with pathological or clinical parameters and were not predictive of patient outcome. Our findings suggest that livin expression in RCC is not of prognostic relevance. Further studies to clarify the role of livin expression in RCC and its potential value as a target for immune-mediated tumor destruction are warranted.

M3 - SCORING: Zeitschriftenaufsatz

VL - 28

SP - 132

EP - 138

JO - TUMOR BIOL

JF - TUMOR BIOL

SN - 1010-4283

IS - 3

M1 - 3

ER -