Expression of podoplanin in nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumours.
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Expression of podoplanin in nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumours. / Friedrich, Reinhard; Scheuer, Hanna; Zustin, Jozef.
In: ANTICANCER RES, Vol. 32, No. 5, 5, 2012, p. 2125-2127.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Expression of podoplanin in nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumours.
AU - Friedrich, Reinhard
AU - Scheuer, Hanna
AU - Zustin, Jozef
PY - 2012
Y1 - 2012
N2 - Keratocystic odontogenic tumour (KCOT) is a benign oral neoplasm of odontogenic origin. The majority of KCOT develop sporadically. The main differential diagnosis of KCOT is from other odontogenic cysts and ameloblastoma. In the rare nevoid basal cell carcinoma syndrome (NBCCS, synonym: Gorlin(-Goltz)-Syndrome), however, KCOTs are frequently detected and may be the initial sign of this clinical syndrome. Podoplanin is a mucin-type transmembrane protein found in podocytes of human kidneys homologous to T1?-2. The expression of podoplanin in some other non-endothelial tissues raised our interest in studying this antibody in tissues of odontogenic origin. Recently, we reported podoplanin expression in sporadic cases of KCOT. We intended to investigate the podoplanin expression in KCOTs associated with NBCCS.
AB - Keratocystic odontogenic tumour (KCOT) is a benign oral neoplasm of odontogenic origin. The majority of KCOT develop sporadically. The main differential diagnosis of KCOT is from other odontogenic cysts and ameloblastoma. In the rare nevoid basal cell carcinoma syndrome (NBCCS, synonym: Gorlin(-Goltz)-Syndrome), however, KCOTs are frequently detected and may be the initial sign of this clinical syndrome. Podoplanin is a mucin-type transmembrane protein found in podocytes of human kidneys homologous to T1?-2. The expression of podoplanin in some other non-endothelial tissues raised our interest in studying this antibody in tissues of odontogenic origin. Recently, we reported podoplanin expression in sporadic cases of KCOT. We intended to investigate the podoplanin expression in KCOTs associated with NBCCS.
KW - Humans
KW - Immunohistochemistry
KW - Basal Cell Nevus Syndrome
KW - Membrane Glycoproteins/analysis/physiology
KW - Membrane Proteins/analysis
KW - Odontogenic Tumors/chemistry/pathology
KW - Humans
KW - Immunohistochemistry
KW - Basal Cell Nevus Syndrome
KW - Membrane Glycoproteins/analysis/physiology
KW - Membrane Proteins/analysis
KW - Odontogenic Tumors/chemistry/pathology
M3 - SCORING: Journal article
VL - 32
SP - 2125
EP - 2127
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 5
M1 - 5
ER -
