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Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines.

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Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines. / Hein, Sybill; Mahner, Sven; Kanowski, Christine; Löning, Thomas; Jänicke, Fritz; Milde-Langosch, Karin.

In: ONCOL REP, Vol. 22, No. 1, 1, 2009, p. 177-183.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hein, S, Mahner, S, Kanowski, C, Löning, T, Jänicke, F & Milde-Langosch, K 2009, 'Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines.', ONCOL REP, vol. 22, no. 1, 1, pp. 177-183. <http://www.ncbi.nlm.nih.gov/pubmed/19513521?dopt=Citation>

APA

Hein, S., Mahner, S., Kanowski, C., Löning, T., Jänicke, F., & Milde-Langosch, K. (2009). Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines. ONCOL REP, 22(1), 177-183. [1]. http://www.ncbi.nlm.nih.gov/pubmed/19513521?dopt=Citation

Vancouver

Hein S, Mahner S, Kanowski C, Löning T, Jänicke F, Milde-Langosch K. Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines. ONCOL REP. 2009;22(1):177-183. 1.

Bibtex

@article{0e93c6097b214ee7b120dcf23736a60a,
title = "Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines.",
abstract = "Jun and Fos proteins form the transcription factor activating protein 1 (AP-1). They play a role in cell proliferation, malignant transformation and invasion in various tumors. The aim of the current study was to characterize the role of AP-1 in ovarian cancer. Fifty-six ovarian tumors of different invasive potential including 13 metastases as well as 5 ovarian cancer cell lines were analyzed by Western blot analysis regarding their expression of pc-Jun, Jun B, Jun D, c-Fos, Fos B, Fra-1 and Fra-2. In addition, invasion, cell proliferation and migration assays were performed. The expression of pc-Jun, Jun B, Jun D and Fra-2 was higher in invasive cancer compared to benign tumors. In metastases, c-Fos and Fos B expression was significantly lower than in the respective primary ovarian carcinomas. The invasive and proliferative potential of the cells was not associated with AP-1 protein expression. These results suggest that AP-1 proteins are differentially expressed in benign ovarian tumors, tumors with low malignant potential and epithelial ovarian carcinomas and metastases. No correlation with the proliferative and invasive potential of ovarian cancer cell lines could be found.",
author = "Sybill Hein and Sven Mahner and Christine Kanowski and Thomas L{\"o}ning and Fritz J{\"a}nicke and Karin Milde-Langosch",
year = "2009",
language = "Deutsch",
volume = "22",
pages = "177--183",
journal = "ONCOL REP",
issn = "1021-335X",
publisher = "Spandidos Publications",
number = "1",

}

RIS

TY - JOUR

T1 - Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines.

AU - Hein, Sybill

AU - Mahner, Sven

AU - Kanowski, Christine

AU - Löning, Thomas

AU - Jänicke, Fritz

AU - Milde-Langosch, Karin

PY - 2009

Y1 - 2009

N2 - Jun and Fos proteins form the transcription factor activating protein 1 (AP-1). They play a role in cell proliferation, malignant transformation and invasion in various tumors. The aim of the current study was to characterize the role of AP-1 in ovarian cancer. Fifty-six ovarian tumors of different invasive potential including 13 metastases as well as 5 ovarian cancer cell lines were analyzed by Western blot analysis regarding their expression of pc-Jun, Jun B, Jun D, c-Fos, Fos B, Fra-1 and Fra-2. In addition, invasion, cell proliferation and migration assays were performed. The expression of pc-Jun, Jun B, Jun D and Fra-2 was higher in invasive cancer compared to benign tumors. In metastases, c-Fos and Fos B expression was significantly lower than in the respective primary ovarian carcinomas. The invasive and proliferative potential of the cells was not associated with AP-1 protein expression. These results suggest that AP-1 proteins are differentially expressed in benign ovarian tumors, tumors with low malignant potential and epithelial ovarian carcinomas and metastases. No correlation with the proliferative and invasive potential of ovarian cancer cell lines could be found.

AB - Jun and Fos proteins form the transcription factor activating protein 1 (AP-1). They play a role in cell proliferation, malignant transformation and invasion in various tumors. The aim of the current study was to characterize the role of AP-1 in ovarian cancer. Fifty-six ovarian tumors of different invasive potential including 13 metastases as well as 5 ovarian cancer cell lines were analyzed by Western blot analysis regarding their expression of pc-Jun, Jun B, Jun D, c-Fos, Fos B, Fra-1 and Fra-2. In addition, invasion, cell proliferation and migration assays were performed. The expression of pc-Jun, Jun B, Jun D and Fra-2 was higher in invasive cancer compared to benign tumors. In metastases, c-Fos and Fos B expression was significantly lower than in the respective primary ovarian carcinomas. The invasive and proliferative potential of the cells was not associated with AP-1 protein expression. These results suggest that AP-1 proteins are differentially expressed in benign ovarian tumors, tumors with low malignant potential and epithelial ovarian carcinomas and metastases. No correlation with the proliferative and invasive potential of ovarian cancer cell lines could be found.

M3 - SCORING: Zeitschriftenaufsatz

VL - 22

SP - 177

EP - 183

JO - ONCOL REP

JF - ONCOL REP

SN - 1021-335X

IS - 1

M1 - 1

ER -