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Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck

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Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck. / Clauditz, T S; Busch, Chia-Jung; Gontarewicz, A; Blessmann, M; Tennstedt, P; Borgmann, K; Tribius, S; Sauter, G; Dalchow, C; Knecht, R; Münscher, A; Wilczak, W.

In: J ORAL PATHOL MED, Vol. 42, No. 2, 01.02.2013, p. 125-32.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Clauditz, TS, Busch, C-J, Gontarewicz, A, Blessmann, M, Tennstedt, P, Borgmann, K, Tribius, S, Sauter, G, Dalchow, C, Knecht, R, Münscher, A & Wilczak, W 2013, 'Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck', J ORAL PATHOL MED, vol. 42, no. 2, pp. 125-32. https://doi.org/10.1111/j.1600-0714.2012.01178.x

APA

Clauditz, T. S., Busch, C-J., Gontarewicz, A., Blessmann, M., Tennstedt, P., Borgmann, K., Tribius, S., Sauter, G., Dalchow, C., Knecht, R., Münscher, A., & Wilczak, W. (2013). Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck. J ORAL PATHOL MED, 42(2), 125-32. https://doi.org/10.1111/j.1600-0714.2012.01178.x

Vancouver

Clauditz TS, Busch C-J, Gontarewicz A, Blessmann M, Tennstedt P, Borgmann K et al. Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck. J ORAL PATHOL MED. 2013 Feb 1;42(2):125-32. https://doi.org/10.1111/j.1600-0714.2012.01178.x

Bibtex

@article{36e1080630ae41bfa5f9e471ad9e2a2d,
title = "Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck",
abstract = "BACKGROUND: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) was found overexpressed in various cancer types suggesting its possible role in carcinogenesis. Analysis of IMP3 expression in head and neck squamous cell carcinomas (HNSCC) is rare so that we evaluated it using tissue microarray method.METHOD: Immunohistochemical analysis of IMP3 was performed on samples from over 400 patients. The expression was measured semiquantitative, subsequently divided into four categories (negative, weak, medium, or strong) and correlated with several available clinicopathologic parameters.RESULTS: For HNSCC, positive IMP3 expression was observed in patients with all tumor stages (pT1-4) and nodal stages (pN0-3), showing also significant statistical correlation (P=0.023 and P=0.0013, respectively). No further correlations were found. Separate analysis according to tumor localization (oral cavity, oropharyngeal, and laryngeal) showed a significant correlation of positive IMP3 expression and overall survival (P=0.038) only in patients with tumors of the oral cavity. Multivariate analysis showed IMP3 as an independent predictive marker for oral squamous cell carcinomas (OSCC).CONCLUSION: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression might be used as an independent prognostic factor in the subgroup of OSCC.",
keywords = "Adult, Aged, Carcinoma, Squamous Cell, Cohort Studies, Disease-Free Survival, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Humans, Immunohistochemistry, Insulin-Like Growth Factor Binding Protein 3, Laryngeal Neoplasms, Lymphatic Metastasis, Male, Middle Aged, Mouth Neoplasms, Neoplasm Grading, Neoplasm Recurrence, Local, Neoplasm Staging, Oropharyngeal Neoplasms, Prognosis, Protein Array Analysis, RNA, Messenger, Retrospective Studies, Survival Rate, Tumor Markers, Biological",
author = "Clauditz, {T S} and Chia-Jung Busch and A Gontarewicz and M Blessmann and P Tennstedt and K Borgmann and S Tribius and G Sauter and C Dalchow and R Knecht and A M{\"u}nscher and W Wilczak",
note = "{\textcopyright} 2012 John Wiley & Sons A/S.",
year = "2013",
month = feb,
day = "1",
doi = "10.1111/j.1600-0714.2012.01178.x",
language = "English",
volume = "42",
pages = "125--32",
journal = "J ORAL PATHOL MED",
issn = "0904-2512",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck

AU - Clauditz, T S

AU - Busch, Chia-Jung

AU - Gontarewicz, A

AU - Blessmann, M

AU - Tennstedt, P

AU - Borgmann, K

AU - Tribius, S

AU - Sauter, G

AU - Dalchow, C

AU - Knecht, R

AU - Münscher, A

AU - Wilczak, W

N1 - © 2012 John Wiley & Sons A/S.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - BACKGROUND: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) was found overexpressed in various cancer types suggesting its possible role in carcinogenesis. Analysis of IMP3 expression in head and neck squamous cell carcinomas (HNSCC) is rare so that we evaluated it using tissue microarray method.METHOD: Immunohistochemical analysis of IMP3 was performed on samples from over 400 patients. The expression was measured semiquantitative, subsequently divided into four categories (negative, weak, medium, or strong) and correlated with several available clinicopathologic parameters.RESULTS: For HNSCC, positive IMP3 expression was observed in patients with all tumor stages (pT1-4) and nodal stages (pN0-3), showing also significant statistical correlation (P=0.023 and P=0.0013, respectively). No further correlations were found. Separate analysis according to tumor localization (oral cavity, oropharyngeal, and laryngeal) showed a significant correlation of positive IMP3 expression and overall survival (P=0.038) only in patients with tumors of the oral cavity. Multivariate analysis showed IMP3 as an independent predictive marker for oral squamous cell carcinomas (OSCC).CONCLUSION: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression might be used as an independent prognostic factor in the subgroup of OSCC.

AB - BACKGROUND: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) was found overexpressed in various cancer types suggesting its possible role in carcinogenesis. Analysis of IMP3 expression in head and neck squamous cell carcinomas (HNSCC) is rare so that we evaluated it using tissue microarray method.METHOD: Immunohistochemical analysis of IMP3 was performed on samples from over 400 patients. The expression was measured semiquantitative, subsequently divided into four categories (negative, weak, medium, or strong) and correlated with several available clinicopathologic parameters.RESULTS: For HNSCC, positive IMP3 expression was observed in patients with all tumor stages (pT1-4) and nodal stages (pN0-3), showing also significant statistical correlation (P=0.023 and P=0.0013, respectively). No further correlations were found. Separate analysis according to tumor localization (oral cavity, oropharyngeal, and laryngeal) showed a significant correlation of positive IMP3 expression and overall survival (P=0.038) only in patients with tumors of the oral cavity. Multivariate analysis showed IMP3 as an independent predictive marker for oral squamous cell carcinomas (OSCC).CONCLUSION: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression might be used as an independent prognostic factor in the subgroup of OSCC.

KW - Adult

KW - Aged

KW - Carcinoma, Squamous Cell

KW - Cohort Studies

KW - Disease-Free Survival

KW - Female

KW - Follow-Up Studies

KW - Gene Expression Regulation, Neoplastic

KW - Head and Neck Neoplasms

KW - Humans

KW - Immunohistochemistry

KW - Insulin-Like Growth Factor Binding Protein 3

KW - Laryngeal Neoplasms

KW - Lymphatic Metastasis

KW - Male

KW - Middle Aged

KW - Mouth Neoplasms

KW - Neoplasm Grading

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Oropharyngeal Neoplasms

KW - Prognosis

KW - Protein Array Analysis

KW - RNA, Messenger

KW - Retrospective Studies

KW - Survival Rate

KW - Tumor Markers, Biological

U2 - 10.1111/j.1600-0714.2012.01178.x

DO - 10.1111/j.1600-0714.2012.01178.x

M3 - SCORING: Journal article

C2 - 22643116

VL - 42

SP - 125

EP - 132

JO - J ORAL PATHOL MED

JF - J ORAL PATHOL MED

SN - 0904-2512

IS - 2

ER -