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Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice

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Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice. / Jojovic, Milan; Delpech, Bertrand; Prehm, Peter; Schumacher, Udo.

In: CANCER LETT, Vol. 188, No. 1-2, 15.12.2002, p. 181-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jojovic, M, Delpech, B, Prehm, P & Schumacher, U 2002, 'Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice', CANCER LETT, vol. 188, no. 1-2, pp. 181-9.

APA

Jojovic, M., Delpech, B., Prehm, P., & Schumacher, U. (2002). Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice. CANCER LETT, 188(1-2), 181-9.

Vancouver

Jojovic M, Delpech B, Prehm P, Schumacher U. Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice. CANCER LETT. 2002 Dec 15;188(1-2):181-9.

Bibtex

@article{74e76a856c1b44d88cbb8d6575fedf10,
title = "Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice",
abstract = "Hyaluronate and hyaluronate synthase expression were examined in primary tumours and if present in metastatic deposits of human breast, colon, ovarian and small-cell lung cancer cell lines transplanted into scid mice using biotinylated hyaluronectin and immunohistochemical staining of hyaluronate synthase. Very intensive hyaluronate and hyaluronate synthase expression could be observed in peripheral areas of tumours derived from highly metastatic cell lines (HT29, MCF-7). Even smaller lung metastases of up to 15 cells showed typically a focal binding of hyaluronectin predominantly at the host-tumour interface of the metastases, indicating that increased expression is closely correlated with the degree of invasiveness and metastatic potential of malignant tumours.",
keywords = "Animals, Breast Neoplasms, Colonic Neoplasms, Female, Glucuronosyltransferase, Glycosyltransferases, Humans, Hyaluronic Acid, Immunoenzyme Techniques, Lung Neoplasms, Male, Membrane Proteins, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, SCID, Neoplasm Metastasis, Neoplasm Transplantation, Ovarian Neoplasms, Transferases, Tumor Cells, Cultured, Xenopus Proteins",
author = "Milan Jojovic and Bertrand Delpech and Peter Prehm and Udo Schumacher",
year = "2002",
month = dec,
day = "15",
language = "English",
volume = "188",
pages = "181--9",
journal = "CANCER LETT",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - Expression of hyaluronate and hyaluronate synthase in human primary tumours and their metastases in scid mice

AU - Jojovic, Milan

AU - Delpech, Bertrand

AU - Prehm, Peter

AU - Schumacher, Udo

PY - 2002/12/15

Y1 - 2002/12/15

N2 - Hyaluronate and hyaluronate synthase expression were examined in primary tumours and if present in metastatic deposits of human breast, colon, ovarian and small-cell lung cancer cell lines transplanted into scid mice using biotinylated hyaluronectin and immunohistochemical staining of hyaluronate synthase. Very intensive hyaluronate and hyaluronate synthase expression could be observed in peripheral areas of tumours derived from highly metastatic cell lines (HT29, MCF-7). Even smaller lung metastases of up to 15 cells showed typically a focal binding of hyaluronectin predominantly at the host-tumour interface of the metastases, indicating that increased expression is closely correlated with the degree of invasiveness and metastatic potential of malignant tumours.

AB - Hyaluronate and hyaluronate synthase expression were examined in primary tumours and if present in metastatic deposits of human breast, colon, ovarian and small-cell lung cancer cell lines transplanted into scid mice using biotinylated hyaluronectin and immunohistochemical staining of hyaluronate synthase. Very intensive hyaluronate and hyaluronate synthase expression could be observed in peripheral areas of tumours derived from highly metastatic cell lines (HT29, MCF-7). Even smaller lung metastases of up to 15 cells showed typically a focal binding of hyaluronectin predominantly at the host-tumour interface of the metastases, indicating that increased expression is closely correlated with the degree of invasiveness and metastatic potential of malignant tumours.

KW - Animals

KW - Breast Neoplasms

KW - Colonic Neoplasms

KW - Female

KW - Glucuronosyltransferase

KW - Glycosyltransferases

KW - Humans

KW - Hyaluronic Acid

KW - Immunoenzyme Techniques

KW - Lung Neoplasms

KW - Male

KW - Membrane Proteins

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C57BL

KW - Mice, SCID

KW - Neoplasm Metastasis

KW - Neoplasm Transplantation

KW - Ovarian Neoplasms

KW - Transferases

KW - Tumor Cells, Cultured

KW - Xenopus Proteins

M3 - SCORING: Journal article

C2 - 12406563

VL - 188

SP - 181

EP - 189

JO - CANCER LETT

JF - CANCER LETT

SN - 0304-3835

IS - 1-2

ER -