Expression of Epithelial-Mesenchymal Transition Regulating Transcription Factors in Head and Neck Squamous Cell Carcinomas
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Expression of Epithelial-Mesenchymal Transition Regulating Transcription Factors in Head and Neck Squamous Cell Carcinomas. / Göppel, Juliane; Möckelmann, Nikolaus; Münscher, Adrian; Sauter, Guido; Schumacher, Udo.
In: ANTICANCER RES, Vol. 37, No. 10, 10.2017, p. 5435-5440.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Expression of Epithelial-Mesenchymal Transition Regulating Transcription Factors in Head and Neck Squamous Cell Carcinomas
AU - Göppel, Juliane
AU - Möckelmann, Nikolaus
AU - Münscher, Adrian
AU - Sauter, Guido
AU - Schumacher, Udo
N1 - Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2017/10
Y1 - 2017/10
N2 - BACKGROUND/AIM: The transcription factors Twist, Snail, Slug, ZEB1 and ZEB2 regulate epithelial-mesenchymal transition (EMT) and their expression has been associated with a poor prognosis in several cancer entities. The aim of this analysis was to investigate in parallel the expression of all of these transcription factors in head and neck squamous cell carcinomas (HNSCCs) in order to gain insight into their possible co-expression.MATERIALS AND METHODS: Tumor tissue samples were immunohistochemically stained using antibodies against these transcription factors. The staining intensity and cellular distribution of the immunoreactivity was recorded.RESULTS: In general, transcription factor immunoreactivity was noted in the nucleus of both cancer and stromal cells. The highest immunoreactivity was observed for Twist. Snail, Slug, ZEB1 and ZEB2 showed a much lesser immunoreactivity in cancer cells and they were expressed independently from each other.CONCLUSION: Twist is the major transcription factor active in HNSCC; the other transcription factors of EMT seem to be of less importance in this tumor entity.
AB - BACKGROUND/AIM: The transcription factors Twist, Snail, Slug, ZEB1 and ZEB2 regulate epithelial-mesenchymal transition (EMT) and their expression has been associated with a poor prognosis in several cancer entities. The aim of this analysis was to investigate in parallel the expression of all of these transcription factors in head and neck squamous cell carcinomas (HNSCCs) in order to gain insight into their possible co-expression.MATERIALS AND METHODS: Tumor tissue samples were immunohistochemically stained using antibodies against these transcription factors. The staining intensity and cellular distribution of the immunoreactivity was recorded.RESULTS: In general, transcription factor immunoreactivity was noted in the nucleus of both cancer and stromal cells. The highest immunoreactivity was observed for Twist. Snail, Slug, ZEB1 and ZEB2 showed a much lesser immunoreactivity in cancer cells and they were expressed independently from each other.CONCLUSION: Twist is the major transcription factor active in HNSCC; the other transcription factors of EMT seem to be of less importance in this tumor entity.
KW - Biomarkers, Tumor
KW - Carcinoma, Squamous Cell
KW - Epithelial-Mesenchymal Transition
KW - Head and Neck Neoplasms
KW - Homeodomain Proteins
KW - Humans
KW - Immunohistochemistry
KW - Nuclear Proteins
KW - Repressor Proteins
KW - Snail Family Transcription Factors
KW - Twist-Related Protein 1
KW - Zinc Finger E-box-Binding Homeobox 1
KW - Comparative Study
KW - Journal Article
U2 - 10.21873/anticanres.11971
DO - 10.21873/anticanres.11971
M3 - SCORING: Journal article
C2 - 28982853
VL - 37
SP - 5435
EP - 5440
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 10
ER -
