Research ExplorerPublicationsExpression and prognostic value of L1-CAM in breast cancer.

Expression and prognostic value of L1-CAM in breast cancer.

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Expression and prognostic value of L1-CAM in breast cancer. / Schröder, Christine; Schumacher, Udo; Fogel, Mina; Feuerhake, Friedrich; Müller, Volkmar; Wirtz, Ralph M; Altevogt, Peter; Krenkel, Sylke; Jänicke, Fritz; Milde-Langosch, Karin.

In: ONCOL REP, Vol. 22, No. 5, 5, 2009, p. 1109-1117.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schröder, C, Schumacher, U, Fogel, M, Feuerhake, F, Müller, V, Wirtz, RM, Altevogt, P, Krenkel, S, Jänicke, F & Milde-Langosch, K 2009, 'Expression and prognostic value of L1-CAM in breast cancer.', ONCOL REP, vol. 22, no. 5, 5, pp. 1109-1117. <http://www.ncbi.nlm.nih.gov/pubmed/19787228?dopt=Citation>

APA

Schröder, C., Schumacher, U., Fogel, M., Feuerhake, F., Müller, V., Wirtz, R. M., Altevogt, P., Krenkel, S., Jänicke, F., & Milde-Langosch, K. (2009). Expression and prognostic value of L1-CAM in breast cancer. ONCOL REP, 22(5), 1109-1117. [5]. http://www.ncbi.nlm.nih.gov/pubmed/19787228?dopt=Citation

Vancouver

Schröder C, Schumacher U, Fogel M, Feuerhake F, Müller V, Wirtz RM et al. Expression and prognostic value of L1-CAM in breast cancer. ONCOL REP. 2009;22(5):1109-1117. 5.

Bibtex

@article{3eafb0c2903846439d954777ed67bf9a,
title = "Expression and prognostic value of L1-CAM in breast cancer.",
abstract = "The L1 adhesion molecule (L1-CAM) is associated with impaired prognosis in many carcinomas. However, limited information about its expression in breast cancer tissue is available. Therefore, we carried out an analysis on L1 expression in primary breast cancers using a combination of Western blot, DNA-microarray analysis and immunohistochemistry. We observed L1 protein and mRNA overexpression in 14-15% of the carcinomas and this was confirmed by immunohistochemical staining. High L1 expression was associated with nodal involvement, high grading, human epidermal growth receptor 2 (Her-2), plasminogen activator inhibitor 1 (PAI-1) and vascular endothelial growth factor (VEGF) expression and a negative estrogen receptor (ER) status, but not with neuroendocrine markers. Moreover, patients with tumors showing high L1-CAM expression had a shorter disease-free and overall survival. Given the emerging functional role of L1 in promoting tumor cell migration, invasion, tumor growth and metastasis, our results suggest that L1 may have this function in breast cancer as well.",
author = "Christine Schr{\"o}der and Udo Schumacher and Mina Fogel and Friedrich Feuerhake and Volkmar M{\"u}ller and Wirtz, {Ralph M} and Peter Altevogt and Sylke Krenkel and Fritz J{\"a}nicke and Karin Milde-Langosch",
year = "2009",
language = "Deutsch",
volume = "22",
pages = "1109--1117",
journal = "ONCOL REP",
issn = "1021-335X",
publisher = "Spandidos Publications",
number = "5",

}

RIS

TY - JOUR

T1 - Expression and prognostic value of L1-CAM in breast cancer.

AU - Schröder, Christine

AU - Schumacher, Udo

AU - Fogel, Mina

AU - Feuerhake, Friedrich

AU - Müller, Volkmar

AU - Wirtz, Ralph M

AU - Altevogt, Peter

AU - Krenkel, Sylke

AU - Jänicke, Fritz

AU - Milde-Langosch, Karin

PY - 2009

Y1 - 2009

N2 - The L1 adhesion molecule (L1-CAM) is associated with impaired prognosis in many carcinomas. However, limited information about its expression in breast cancer tissue is available. Therefore, we carried out an analysis on L1 expression in primary breast cancers using a combination of Western blot, DNA-microarray analysis and immunohistochemistry. We observed L1 protein and mRNA overexpression in 14-15% of the carcinomas and this was confirmed by immunohistochemical staining. High L1 expression was associated with nodal involvement, high grading, human epidermal growth receptor 2 (Her-2), plasminogen activator inhibitor 1 (PAI-1) and vascular endothelial growth factor (VEGF) expression and a negative estrogen receptor (ER) status, but not with neuroendocrine markers. Moreover, patients with tumors showing high L1-CAM expression had a shorter disease-free and overall survival. Given the emerging functional role of L1 in promoting tumor cell migration, invasion, tumor growth and metastasis, our results suggest that L1 may have this function in breast cancer as well.

AB - The L1 adhesion molecule (L1-CAM) is associated with impaired prognosis in many carcinomas. However, limited information about its expression in breast cancer tissue is available. Therefore, we carried out an analysis on L1 expression in primary breast cancers using a combination of Western blot, DNA-microarray analysis and immunohistochemistry. We observed L1 protein and mRNA overexpression in 14-15% of the carcinomas and this was confirmed by immunohistochemical staining. High L1 expression was associated with nodal involvement, high grading, human epidermal growth receptor 2 (Her-2), plasminogen activator inhibitor 1 (PAI-1) and vascular endothelial growth factor (VEGF) expression and a negative estrogen receptor (ER) status, but not with neuroendocrine markers. Moreover, patients with tumors showing high L1-CAM expression had a shorter disease-free and overall survival. Given the emerging functional role of L1 in promoting tumor cell migration, invasion, tumor growth and metastasis, our results suggest that L1 may have this function in breast cancer as well.

M3 - SCORING: Zeitschriftenaufsatz

VL - 22

SP - 1109

EP - 1117

JO - ONCOL REP

JF - ONCOL REP

SN - 1021-335X

IS - 5

M1 - 5

ER -