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Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma.

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Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma. / Pabst, Caroline; Zustin, Jozef; Jacobsen, Frank; Luetkens, Tim; Kröger, Nicolaus; Schilling, Georgia; Bokemeyer, Carsten; Sauter, Guido; Atanackovic, Djordje; Marx, Andreas.

In: EXP MOL PATHOL, Vol. 89, No. 2, 2, 2010, p. 175-181.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pabst, C, Zustin, J, Jacobsen, F, Luetkens, T, Kröger, N, Schilling, G, Bokemeyer, C, Sauter, G, Atanackovic, D & Marx, A 2010, 'Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma.', EXP MOL PATHOL, vol. 89, no. 2, 2, pp. 175-181. <http://www.ncbi.nlm.nih.gov/pubmed/20621094?dopt=Citation>

APA

Pabst, C., Zustin, J., Jacobsen, F., Luetkens, T., Kröger, N., Schilling, G., Bokemeyer, C., Sauter, G., Atanackovic, D., & Marx, A. (2010). Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma. EXP MOL PATHOL, 89(2), 175-181. [2]. http://www.ncbi.nlm.nih.gov/pubmed/20621094?dopt=Citation

Vancouver

Pabst C, Zustin J, Jacobsen F, Luetkens T, Kröger N, Schilling G et al. Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma. EXP MOL PATHOL. 2010;89(2):175-181. 2.

Bibtex

@article{ace4fadd226c4ffba51c2f88386fd4e3,
title = "Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma.",
abstract = "Cancer-testis (CT) antigens are promising targets for antigen-specific therapy of multiple myeloma (MM). Osteolytic lesions represent the most common clinical manifestation of myeloma and it is possible that osseous myeloma lesions differ from bone-infiltrating tumor cells with regard to the extent of CT antigen expression based on the epigenetic regulation of these genes. We, therefore, performed the first analysis of CT antigen expression in osteolytic lesions of myeloma patients to further define the diagnostic, prognostic, and therapeutic value of these proteins. Lytic bone samples were obtained from MM patients during surgical interventions and a tissue microarray was constructed. 105 bone samples and 24 bone marrow biopsies were stained immunohistochemically with antibodies against CT antigens MAGE-C1/CT7 and MAGE-C2/CT10 and Ki-67. MAGE-C1/CT7 and MAGE-C2/CT10 were frequently expressed in osteolytic lesions (46% and 54%) and bone marrow (75% and 54%). Expression of MAGE-C1/CT7 was significantly more frequent in patients with advanced stage of disease (p=0.023) and with a chromosomal deletion 17p13 (p53) (p=0.047). Samples with more than 75% MAGE-C1/CT7 expressing myeloma cells showed a higher proliferative rate (indicated by the expression of Ki67) than those with less than 25% MAGE-C1/CT7 expressing cells (p=0.011). Moreover, a content of 50% MAGE-C1/CT7 expressing myeloma cells in a sample was associated with reduced overall survival (p=0.013). Our results, therefore, suggest that expression of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes.",
author = "Caroline Pabst and Jozef Zustin and Frank Jacobsen and Tim Luetkens and Nicolaus Kr{\"o}ger and Georgia Schilling and Carsten Bokemeyer and Guido Sauter and Djordje Atanackovic and Andreas Marx",
year = "2010",
language = "Deutsch",
volume = "89",
pages = "175--181",
journal = "EXP MOL PATHOL",
issn = "0014-4800",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma.

AU - Pabst, Caroline

AU - Zustin, Jozef

AU - Jacobsen, Frank

AU - Luetkens, Tim

AU - Kröger, Nicolaus

AU - Schilling, Georgia

AU - Bokemeyer, Carsten

AU - Sauter, Guido

AU - Atanackovic, Djordje

AU - Marx, Andreas

PY - 2010

Y1 - 2010

N2 - Cancer-testis (CT) antigens are promising targets for antigen-specific therapy of multiple myeloma (MM). Osteolytic lesions represent the most common clinical manifestation of myeloma and it is possible that osseous myeloma lesions differ from bone-infiltrating tumor cells with regard to the extent of CT antigen expression based on the epigenetic regulation of these genes. We, therefore, performed the first analysis of CT antigen expression in osteolytic lesions of myeloma patients to further define the diagnostic, prognostic, and therapeutic value of these proteins. Lytic bone samples were obtained from MM patients during surgical interventions and a tissue microarray was constructed. 105 bone samples and 24 bone marrow biopsies were stained immunohistochemically with antibodies against CT antigens MAGE-C1/CT7 and MAGE-C2/CT10 and Ki-67. MAGE-C1/CT7 and MAGE-C2/CT10 were frequently expressed in osteolytic lesions (46% and 54%) and bone marrow (75% and 54%). Expression of MAGE-C1/CT7 was significantly more frequent in patients with advanced stage of disease (p=0.023) and with a chromosomal deletion 17p13 (p53) (p=0.047). Samples with more than 75% MAGE-C1/CT7 expressing myeloma cells showed a higher proliferative rate (indicated by the expression of Ki67) than those with less than 25% MAGE-C1/CT7 expressing cells (p=0.011). Moreover, a content of 50% MAGE-C1/CT7 expressing myeloma cells in a sample was associated with reduced overall survival (p=0.013). Our results, therefore, suggest that expression of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes.

AB - Cancer-testis (CT) antigens are promising targets for antigen-specific therapy of multiple myeloma (MM). Osteolytic lesions represent the most common clinical manifestation of myeloma and it is possible that osseous myeloma lesions differ from bone-infiltrating tumor cells with regard to the extent of CT antigen expression based on the epigenetic regulation of these genes. We, therefore, performed the first analysis of CT antigen expression in osteolytic lesions of myeloma patients to further define the diagnostic, prognostic, and therapeutic value of these proteins. Lytic bone samples were obtained from MM patients during surgical interventions and a tissue microarray was constructed. 105 bone samples and 24 bone marrow biopsies were stained immunohistochemically with antibodies against CT antigens MAGE-C1/CT7 and MAGE-C2/CT10 and Ki-67. MAGE-C1/CT7 and MAGE-C2/CT10 were frequently expressed in osteolytic lesions (46% and 54%) and bone marrow (75% and 54%). Expression of MAGE-C1/CT7 was significantly more frequent in patients with advanced stage of disease (p=0.023) and with a chromosomal deletion 17p13 (p53) (p=0.047). Samples with more than 75% MAGE-C1/CT7 expressing myeloma cells showed a higher proliferative rate (indicated by the expression of Ki67) than those with less than 25% MAGE-C1/CT7 expressing cells (p=0.011). Moreover, a content of 50% MAGE-C1/CT7 expressing myeloma cells in a sample was associated with reduced overall survival (p=0.013). Our results, therefore, suggest that expression of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes.

M3 - SCORING: Zeitschriftenaufsatz

VL - 89

SP - 175

EP - 181

JO - EXP MOL PATHOL

JF - EXP MOL PATHOL

SN - 0014-4800

IS - 2

M1 - 2

ER -