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Expression and genetic polymorphism of necroptosis related protein RIPK1 is correlated with severe hepatic ischemia-reperfusion injury and prognosis after hepatectomy in hepatocellular carcinoma patients

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Expression and genetic polymorphism of necroptosis related protein RIPK1 is correlated with severe hepatic ischemia-reperfusion injury and prognosis after hepatectomy in hepatocellular carcinoma patients. / Yao, Chen; Li, Gang; Cai, Ming; Qian, Yeyong; Wang, Liqin; Xiao, Li; Thaiss, Friedrich; Shi, Bingyi.

In: CANCER BIOMARK, Vol. 20, No. 1, 19.07.2017, p. 23-29.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Yao, C, Li, G, Cai, M, Qian, Y, Wang, L, Xiao, L, Thaiss, F & Shi, B 2017, 'Expression and genetic polymorphism of necroptosis related protein RIPK1 is correlated with severe hepatic ischemia-reperfusion injury and prognosis after hepatectomy in hepatocellular carcinoma patients', CANCER BIOMARK, vol. 20, no. 1, pp. 23-29. https://doi.org/10.3233/CBM-170525

APA

Yao, C., Li, G., Cai, M., Qian, Y., Wang, L., Xiao, L., Thaiss, F., & Shi, B. (2017). Expression and genetic polymorphism of necroptosis related protein RIPK1 is correlated with severe hepatic ischemia-reperfusion injury and prognosis after hepatectomy in hepatocellular carcinoma patients. CANCER BIOMARK, 20(1), 23-29. https://doi.org/10.3233/CBM-170525

Vancouver

Yao C, Li G, Cai M, Qian Y, Wang L, Xiao L et al. Expression and genetic polymorphism of necroptosis related protein RIPK1 is correlated with severe hepatic ischemia-reperfusion injury and prognosis after hepatectomy in hepatocellular carcinoma patients. CANCER BIOMARK. 2017 Jul 19;20(1):23-29. https://doi.org/10.3233/CBM-170525

Bibtex

@article{27a4946667e0424d856372395a979462,
title = "Expression and genetic polymorphism of necroptosis related protein RIPK1 is correlated with severe hepatic ischemia-reperfusion injury and prognosis after hepatectomy in hepatocellular carcinoma patients",
abstract = "OBJECTIVES: The goal of our study was to assess the prognostic impact of the necroptosis relative protein RIPK1 genetic polymorphism in ischemia-reperfusion injury and survival after hepatectomy in hepatocellular carcinoma (HCC) patients.METHODS: In this study, expression of RIPK1 and its genetic polymorphism(rs2272990) were examined in plasma of 44 HCC patients. All these patients were undergoing partial hepatectomy. The prognostic values of RIPK1 genetic polymorphism for tumor development and survival, and ischemia-reperfusion injury after hepatectomy were further determined.RESULTS: Plasma RIPK1 expressions were significantly increased in HCC patients, compared to the healthy control group. Totally 19 patients have the GA + AA genotype in the RIPK1 rs2272990 SNP site and 25 have GG genotype. There were no statistically significant intergroup differences observed in age, gender, AFP value, HBV positive, tumor size or cirrhosis. GG genotype had positive correlation with TNM classification (p= 0.033) and lymphatic metastasis (p= 0.027) and was significantly associated with severe hepatic ischemia-reperfusion injury and decreased survival rate after hepatectomy.CONCLUSION: In conclusion, the RIPK1 polymorphism is an indicator of hepatic injury and a novel prognostic biomarker for tumor development and survival of HCC recipients after hepatectomy.",
keywords = "Apoptosis, Biomarkers, Tumor, Carcinoma, Hepatocellular, Female, Gene Expression Regulation, Neoplastic, Gene Frequency, Genotype, Hepatectomy, Humans, Kaplan-Meier Estimate, Liver, Liver Neoplasms, Male, Middle Aged, Necrosis, Polymorphism, Single Nucleotide, Prognosis, Receptor-Interacting Protein Serine-Threonine Kinases, Reperfusion Injury, Journal Article",
author = "Chen Yao and Gang Li and Ming Cai and Yeyong Qian and Liqin Wang and Li Xiao and Friedrich Thaiss and Bingyi Shi",
year = "2017",
month = jul,
day = "19",
doi = "10.3233/CBM-170525",
language = "English",
volume = "20",
pages = "23--29",
journal = "CANCER BIOMARK",
issn = "1574-0153",
publisher = "IOS Press",
number = "1",

}

RIS

TY - JOUR

T1 - Expression and genetic polymorphism of necroptosis related protein RIPK1 is correlated with severe hepatic ischemia-reperfusion injury and prognosis after hepatectomy in hepatocellular carcinoma patients

AU - Yao, Chen

AU - Li, Gang

AU - Cai, Ming

AU - Qian, Yeyong

AU - Wang, Liqin

AU - Xiao, Li

AU - Thaiss, Friedrich

AU - Shi, Bingyi

PY - 2017/7/19

Y1 - 2017/7/19

N2 - OBJECTIVES: The goal of our study was to assess the prognostic impact of the necroptosis relative protein RIPK1 genetic polymorphism in ischemia-reperfusion injury and survival after hepatectomy in hepatocellular carcinoma (HCC) patients.METHODS: In this study, expression of RIPK1 and its genetic polymorphism(rs2272990) were examined in plasma of 44 HCC patients. All these patients were undergoing partial hepatectomy. The prognostic values of RIPK1 genetic polymorphism for tumor development and survival, and ischemia-reperfusion injury after hepatectomy were further determined.RESULTS: Plasma RIPK1 expressions were significantly increased in HCC patients, compared to the healthy control group. Totally 19 patients have the GA + AA genotype in the RIPK1 rs2272990 SNP site and 25 have GG genotype. There were no statistically significant intergroup differences observed in age, gender, AFP value, HBV positive, tumor size or cirrhosis. GG genotype had positive correlation with TNM classification (p= 0.033) and lymphatic metastasis (p= 0.027) and was significantly associated with severe hepatic ischemia-reperfusion injury and decreased survival rate after hepatectomy.CONCLUSION: In conclusion, the RIPK1 polymorphism is an indicator of hepatic injury and a novel prognostic biomarker for tumor development and survival of HCC recipients after hepatectomy.

AB - OBJECTIVES: The goal of our study was to assess the prognostic impact of the necroptosis relative protein RIPK1 genetic polymorphism in ischemia-reperfusion injury and survival after hepatectomy in hepatocellular carcinoma (HCC) patients.METHODS: In this study, expression of RIPK1 and its genetic polymorphism(rs2272990) were examined in plasma of 44 HCC patients. All these patients were undergoing partial hepatectomy. The prognostic values of RIPK1 genetic polymorphism for tumor development and survival, and ischemia-reperfusion injury after hepatectomy were further determined.RESULTS: Plasma RIPK1 expressions were significantly increased in HCC patients, compared to the healthy control group. Totally 19 patients have the GA + AA genotype in the RIPK1 rs2272990 SNP site and 25 have GG genotype. There were no statistically significant intergroup differences observed in age, gender, AFP value, HBV positive, tumor size or cirrhosis. GG genotype had positive correlation with TNM classification (p= 0.033) and lymphatic metastasis (p= 0.027) and was significantly associated with severe hepatic ischemia-reperfusion injury and decreased survival rate after hepatectomy.CONCLUSION: In conclusion, the RIPK1 polymorphism is an indicator of hepatic injury and a novel prognostic biomarker for tumor development and survival of HCC recipients after hepatectomy.

KW - Apoptosis

KW - Biomarkers, Tumor

KW - Carcinoma, Hepatocellular

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Gene Frequency

KW - Genotype

KW - Hepatectomy

KW - Humans

KW - Kaplan-Meier Estimate

KW - Liver

KW - Liver Neoplasms

KW - Male

KW - Middle Aged

KW - Necrosis

KW - Polymorphism, Single Nucleotide

KW - Prognosis

KW - Receptor-Interacting Protein Serine-Threonine Kinases

KW - Reperfusion Injury

KW - Journal Article

U2 - 10.3233/CBM-170525

DO - 10.3233/CBM-170525

M3 - SCORING: Journal article

C2 - 28759952

VL - 20

SP - 23

EP - 29

JO - CANCER BIOMARK

JF - CANCER BIOMARK

SN - 1574-0153

IS - 1

ER -