Expert clinical management of autoimmune hepatitis in the real world
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Expert clinical management of autoimmune hepatitis in the real world. / Liberal, R; de Boer, Y S; Andrade, R J; Bouma, G; Dalekos, G N; Floreani, A; Gleeson, D; Hirschfield, G M; Invernizzi, P; Lenzi, M; Lohse, A W; Macedo, G; Milkiewicz, P; Terziroli, B; van Hoek, B; Vierling, J M; Heneghan, M A; International Autoimmune Hepatitis Group (IAIHG).
In: ALIMENT PHARM THER, Vol. 45, No. 5, 03.2017, p. 723-732.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Expert clinical management of autoimmune hepatitis in the real world
AU - Liberal, R
AU - de Boer, Y S
AU - Andrade, R J
AU - Bouma, G
AU - Dalekos, G N
AU - Floreani, A
AU - Gleeson, D
AU - Hirschfield, G M
AU - Invernizzi, P
AU - Lenzi, M
AU - Lohse, A W
AU - Macedo, G
AU - Milkiewicz, P
AU - Terziroli, B
AU - van Hoek, B
AU - Vierling, J M
AU - Heneghan, M A
AU - International Autoimmune Hepatitis Group (IAIHG)
N1 - © 2016 John Wiley & Sons Ltd.
PY - 2017/3
Y1 - 2017/3
N2 - BACKGROUND: High-quality data on the management of autoimmune hepatitis (AIH) are scarce. Despite published guidelines, management of AIH is still expert based rather than evidence based.AIM: To survey expert hepatologists, asking each to describe their practices in the management of patients with AIH.METHODS: A survey questionnaire was distributed to members of the International AIH Group. The questionnaire consisted of four clinical scenarios on different presentations of AIH.RESULTS: Sixty surveys were sent, out of which 37 were returned. None reported budesonide as a first line induction agent for the acute presentation of AIH. Five (14%) participants reported using thiopurine S-methyltransferase measurements before commencement of thiopurine maintenance therapy. Thirteen (35%) routinely perform liver biopsy at 2 years of biochemical remission. If histological inflammatory activity is absent, four (11%) participants reduced azathioprine, whereas 10 (27%) attempted withdrawal altogether. Regarding the management of difficult-to-treat patients, mycophenolate mofetil is the most widely used second-line agent (n = ~450 in 28 centres), whereas tacrolimus (n = ~115 in 21 centres) and ciclosporin (n = ~112 in 18 centres) are less often reported. One centre reported considerable experience with infliximab, while rescue therapy with rituximab has been tried in seven centres.CONCLUSIONS: There is a wide variation in the management of patients with autoimmune hepatitis even among the most expert in the field. Although good quality evidence is lacking, there is considerable experience with second-line therapies. Future prospective studies should address these issues, so that we move from an expert- to an evidence- and personalised-based care in autoimmune hepatitis.
AB - BACKGROUND: High-quality data on the management of autoimmune hepatitis (AIH) are scarce. Despite published guidelines, management of AIH is still expert based rather than evidence based.AIM: To survey expert hepatologists, asking each to describe their practices in the management of patients with AIH.METHODS: A survey questionnaire was distributed to members of the International AIH Group. The questionnaire consisted of four clinical scenarios on different presentations of AIH.RESULTS: Sixty surveys were sent, out of which 37 were returned. None reported budesonide as a first line induction agent for the acute presentation of AIH. Five (14%) participants reported using thiopurine S-methyltransferase measurements before commencement of thiopurine maintenance therapy. Thirteen (35%) routinely perform liver biopsy at 2 years of biochemical remission. If histological inflammatory activity is absent, four (11%) participants reduced azathioprine, whereas 10 (27%) attempted withdrawal altogether. Regarding the management of difficult-to-treat patients, mycophenolate mofetil is the most widely used second-line agent (n = ~450 in 28 centres), whereas tacrolimus (n = ~115 in 21 centres) and ciclosporin (n = ~112 in 18 centres) are less often reported. One centre reported considerable experience with infliximab, while rescue therapy with rituximab has been tried in seven centres.CONCLUSIONS: There is a wide variation in the management of patients with autoimmune hepatitis even among the most expert in the field. Although good quality evidence is lacking, there is considerable experience with second-line therapies. Future prospective studies should address these issues, so that we move from an expert- to an evidence- and personalised-based care in autoimmune hepatitis.
U2 - 10.1111/apt.13907
DO - 10.1111/apt.13907
M3 - SCORING: Journal article
C2 - 28004405
VL - 45
SP - 723
EP - 732
JO - ALIMENT PHARM THER
JF - ALIMENT PHARM THER
SN - 0269-2813
IS - 5
ER -