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Experimental Models: Cell Culture and Animal Models

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Experimental Models: Cell Culture and Animal Models. / Dandri-Petersen, Maura; Volz, Tassilo; Lütgehetmann, Marc.

Hepatitis B Virus in Human Diseases . ed. / Yun-Fan Liaw ; Fabien Zoulim. 1. ed. Springer International Publishing, 2015. p. 35-62 (Molecular and Translational Medicine).

Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

Harvard

Dandri-Petersen, M, Volz, T & Lütgehetmann, M 2015, Experimental Models: Cell Culture and Animal Models. in Y-F Liaw & F Zoulim (eds), Hepatitis B Virus in Human Diseases . 1 edn, Molecular and Translational Medicine, Springer International Publishing, pp. 35-62. https://doi.org/10.1007/978-3-319-22330-8_2

APA

Dandri-Petersen, M., Volz, T., & Lütgehetmann, M. (2015). Experimental Models: Cell Culture and Animal Models. In Y-F. Liaw , & F. Zoulim (Eds.), Hepatitis B Virus in Human Diseases (1 ed., pp. 35-62). (Molecular and Translational Medicine). Springer International Publishing. https://doi.org/10.1007/978-3-319-22330-8_2

Vancouver

Dandri-Petersen M, Volz T, Lütgehetmann M. Experimental Models: Cell Culture and Animal Models. In Liaw Y-F, Zoulim F, editors, Hepatitis B Virus in Human Diseases . 1 ed. Springer International Publishing. 2015. p. 35-62. (Molecular and Translational Medicine). https://doi.org/10.1007/978-3-319-22330-8_2

Bibtex

@inbook{0e3a1f1b709c451192753084e3a607ac,
title = "Experimental Models: Cell Culture and Animal Models",
abstract = "Experimental models are indispensable tools for studying the biology of virus infection and for drug development. The narrow host range of hepatitis B virus (HBV), the lack of robust in vitro infection systems and the strong limitations imposed by the use of high primates have hindered progresses in drug development and understanding the complex network of virus-host interactions that are established in the course of HBV infection. Since mice and rats are not permissive for any of the known Hepadnaviridae, most research advances have been achieved by using transfection systems and outbred animal models based on HBV-related Hepadnaviridae and their relative hosts. The recent discovery of the cellular receptor mediating HBV entry is opening new possibilities to recapitulate the entire lifecycle in HBV-permissive hepatoma cell lines. This review focuses on summarizing recent advances obtained with well-established and more innovative experimental models, placing emphasis on the strength of new in vitro and in vivo infection systems that may serve as tools for elucidating still unknown steps of HBV biology, as well as for preclinical drug evaluation",
author = "Maura Dandri-Petersen and Tassilo Volz and Marc L{\"u}tgehetmann",
year = "2015",
doi = "10.1007/978-3-319-22330-8_2",
language = "English",
isbn = "978-3-319-22329-2",
series = "Molecular and Translational Medicine",
publisher = "Springer International Publishing",
pages = "35--62",
editor = "{Liaw }, Yun-Fan and Fabien Zoulim",
booktitle = "Hepatitis B Virus in Human Diseases",
address = "Switzerland",
edition = "1",

}

RIS

TY - CHAP

T1 - Experimental Models: Cell Culture and Animal Models

AU - Dandri-Petersen, Maura

AU - Volz, Tassilo

AU - Lütgehetmann, Marc

PY - 2015

Y1 - 2015

N2 - Experimental models are indispensable tools for studying the biology of virus infection and for drug development. The narrow host range of hepatitis B virus (HBV), the lack of robust in vitro infection systems and the strong limitations imposed by the use of high primates have hindered progresses in drug development and understanding the complex network of virus-host interactions that are established in the course of HBV infection. Since mice and rats are not permissive for any of the known Hepadnaviridae, most research advances have been achieved by using transfection systems and outbred animal models based on HBV-related Hepadnaviridae and their relative hosts. The recent discovery of the cellular receptor mediating HBV entry is opening new possibilities to recapitulate the entire lifecycle in HBV-permissive hepatoma cell lines. This review focuses on summarizing recent advances obtained with well-established and more innovative experimental models, placing emphasis on the strength of new in vitro and in vivo infection systems that may serve as tools for elucidating still unknown steps of HBV biology, as well as for preclinical drug evaluation

AB - Experimental models are indispensable tools for studying the biology of virus infection and for drug development. The narrow host range of hepatitis B virus (HBV), the lack of robust in vitro infection systems and the strong limitations imposed by the use of high primates have hindered progresses in drug development and understanding the complex network of virus-host interactions that are established in the course of HBV infection. Since mice and rats are not permissive for any of the known Hepadnaviridae, most research advances have been achieved by using transfection systems and outbred animal models based on HBV-related Hepadnaviridae and their relative hosts. The recent discovery of the cellular receptor mediating HBV entry is opening new possibilities to recapitulate the entire lifecycle in HBV-permissive hepatoma cell lines. This review focuses on summarizing recent advances obtained with well-established and more innovative experimental models, placing emphasis on the strength of new in vitro and in vivo infection systems that may serve as tools for elucidating still unknown steps of HBV biology, as well as for preclinical drug evaluation

U2 - 10.1007/978-3-319-22330-8_2

DO - 10.1007/978-3-319-22330-8_2

M3 - SCORING: Contribution to collected editions/anthologies

SN - 978-3-319-22329-2

T3 - Molecular and Translational Medicine

SP - 35

EP - 62

BT - Hepatitis B Virus in Human Diseases

A2 - Liaw , Yun-Fan

A2 - Zoulim, Fabien

PB - Springer International Publishing

ER -