The study focuses on the outcome of oncological rehabilitation in the inpatient setting. An oncology-specific questionnaire for the measurement of individual therapy goals was developed within the perspective of a goal-oriented evaluation concept. The article focuses on the first time-point of measurement (beginning of the rehabilitation measure) within a longitudinal study. 407 patients were studied either directly following their initial hospital treatment or at a later time-point during the course of the cancer illness. The presentation of the results include firstly a description and analysis of the patients' medical and psychosocial situation (including variables such as the perceived state of health and quality of life), as well as individual rehabilitation goals formulated by the patients themselves. Moreover, an analysis is performed of the expectations, hopes and fears of patients at the beginning of an oncological rehabilitation measure in the inpatient setting. Subgroup analyses focus on the influence of sociodemographic and emotional variables on the patients' expectations and goals.