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Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls

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Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls. / Ristow, Inka; Foell, Jens; Kärgel, Christian; Borchardt, Viola; Li, Shijia; Denzel, Dominik; Witzel, Joachim; Drumkova, Krasimira; Beier, Klaus; Kruger, Tillmann H C; Ponseti, Jorge; Schiffer, Boris; Schiltz, Kolja; Walter, Henrik; Walter, Martin.

In: NEUROIMAGE-CLIN, Vol. 23, 22.05.2019, p. 101863.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ristow, I, Foell, J, Kärgel, C, Borchardt, V, Li, S, Denzel, D, Witzel, J, Drumkova, K, Beier, K, Kruger, THC, Ponseti, J, Schiffer, B, Schiltz, K, Walter, H & Walter, M 2019, 'Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls', NEUROIMAGE-CLIN, vol. 23, pp. 101863. https://doi.org/10.1016/j.nicl.2019.101863

APA

Ristow, I., Foell, J., Kärgel, C., Borchardt, V., Li, S., Denzel, D., Witzel, J., Drumkova, K., Beier, K., Kruger, T. H. C., Ponseti, J., Schiffer, B., Schiltz, K., Walter, H., & Walter, M. (2019). Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls. NEUROIMAGE-CLIN, 23, 101863. https://doi.org/10.1016/j.nicl.2019.101863

Vancouver

Ristow I, Foell J, Kärgel C, Borchardt V, Li S, Denzel D et al. Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls. NEUROIMAGE-CLIN. 2019 May 22;23:101863. https://doi.org/10.1016/j.nicl.2019.101863

Bibtex

@article{d045c6e8aee74c4ab0a00e8104567a06,
title = "Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls",
abstract = "BACKGROUND: Pedophilic disorder is characterized by increased sexual interest towards children, with comparatively lesser interest towards adults. In real life, the behavior of subjects with pedophilic disorder is shaped by evaluative processes in response to sexually relevant cues. Therefore, brain activation during anticipation of sexually relevant cues is of potential interest. Whereas previous research demonstrated reduced activation when viewing adult (non-preferred) sexual stimuli in pedophilic sex offenders (PSOs), it is not known if anticipation of preferred versus unpreferred stimuli will elicit differential brain activation.METHODS: Two fMRI studies (1.5 and 7 Tesla) were conducted in separate samples, each with 26 subjects (13/13 PSOs/controls) to assess brain activity during expectancy of subsequent adult (non-preferred) sexual stimuli. In the second study (7 Tesla) additionally child (preferred) cues were presented.RESULTS: As predicted, expectancy of adult sexual stimuli generated smaller dorsal anterior cingulate cortex (dACC) activation in PSOs in both studies, driven by stronger activation during expectancy of adult erotic stimuli in non-pedophilic controls (HCs). In the second study, PSOs showed significantly increased activations in dACC during expectancy of child stimuli compared with expectancy of adult stimuli. This difference was significantly greater compared to the same contrast in HCs, thus demonstrating preference specificity of dACC activation.CONCLUSION: Our findings support the notion of decreased brain activation to adult cues in PSOs and preference specificity in neural response during expectancy of erotic stimuli. The localization of these cue reactivity differences in the salience network supports the interpretation that PSOs show abnormally increased preparatory activation even before relevant sexual stimuli are actually presented.",
author = "Inka Ristow and Jens Foell and Christian K{\"a}rgel and Viola Borchardt and Shijia Li and Dominik Denzel and Joachim Witzel and Krasimira Drumkova and Klaus Beier and Kruger, {Tillmann H C} and Jorge Ponseti and Boris Schiffer and Kolja Schiltz and Henrik Walter and Martin Walter",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = may,
day = "22",
doi = "10.1016/j.nicl.2019.101863",
language = "English",
volume = "23",
pages = "101863",
journal = "NEUROIMAGE-CLIN",
issn = "2213-1582",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls

AU - Ristow, Inka

AU - Foell, Jens

AU - Kärgel, Christian

AU - Borchardt, Viola

AU - Li, Shijia

AU - Denzel, Dominik

AU - Witzel, Joachim

AU - Drumkova, Krasimira

AU - Beier, Klaus

AU - Kruger, Tillmann H C

AU - Ponseti, Jorge

AU - Schiffer, Boris

AU - Schiltz, Kolja

AU - Walter, Henrik

AU - Walter, Martin

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/5/22

Y1 - 2019/5/22

N2 - BACKGROUND: Pedophilic disorder is characterized by increased sexual interest towards children, with comparatively lesser interest towards adults. In real life, the behavior of subjects with pedophilic disorder is shaped by evaluative processes in response to sexually relevant cues. Therefore, brain activation during anticipation of sexually relevant cues is of potential interest. Whereas previous research demonstrated reduced activation when viewing adult (non-preferred) sexual stimuli in pedophilic sex offenders (PSOs), it is not known if anticipation of preferred versus unpreferred stimuli will elicit differential brain activation.METHODS: Two fMRI studies (1.5 and 7 Tesla) were conducted in separate samples, each with 26 subjects (13/13 PSOs/controls) to assess brain activity during expectancy of subsequent adult (non-preferred) sexual stimuli. In the second study (7 Tesla) additionally child (preferred) cues were presented.RESULTS: As predicted, expectancy of adult sexual stimuli generated smaller dorsal anterior cingulate cortex (dACC) activation in PSOs in both studies, driven by stronger activation during expectancy of adult erotic stimuli in non-pedophilic controls (HCs). In the second study, PSOs showed significantly increased activations in dACC during expectancy of child stimuli compared with expectancy of adult stimuli. This difference was significantly greater compared to the same contrast in HCs, thus demonstrating preference specificity of dACC activation.CONCLUSION: Our findings support the notion of decreased brain activation to adult cues in PSOs and preference specificity in neural response during expectancy of erotic stimuli. The localization of these cue reactivity differences in the salience network supports the interpretation that PSOs show abnormally increased preparatory activation even before relevant sexual stimuli are actually presented.

AB - BACKGROUND: Pedophilic disorder is characterized by increased sexual interest towards children, with comparatively lesser interest towards adults. In real life, the behavior of subjects with pedophilic disorder is shaped by evaluative processes in response to sexually relevant cues. Therefore, brain activation during anticipation of sexually relevant cues is of potential interest. Whereas previous research demonstrated reduced activation when viewing adult (non-preferred) sexual stimuli in pedophilic sex offenders (PSOs), it is not known if anticipation of preferred versus unpreferred stimuli will elicit differential brain activation.METHODS: Two fMRI studies (1.5 and 7 Tesla) were conducted in separate samples, each with 26 subjects (13/13 PSOs/controls) to assess brain activity during expectancy of subsequent adult (non-preferred) sexual stimuli. In the second study (7 Tesla) additionally child (preferred) cues were presented.RESULTS: As predicted, expectancy of adult sexual stimuli generated smaller dorsal anterior cingulate cortex (dACC) activation in PSOs in both studies, driven by stronger activation during expectancy of adult erotic stimuli in non-pedophilic controls (HCs). In the second study, PSOs showed significantly increased activations in dACC during expectancy of child stimuli compared with expectancy of adult stimuli. This difference was significantly greater compared to the same contrast in HCs, thus demonstrating preference specificity of dACC activation.CONCLUSION: Our findings support the notion of decreased brain activation to adult cues in PSOs and preference specificity in neural response during expectancy of erotic stimuli. The localization of these cue reactivity differences in the salience network supports the interpretation that PSOs show abnormally increased preparatory activation even before relevant sexual stimuli are actually presented.

U2 - 10.1016/j.nicl.2019.101863

DO - 10.1016/j.nicl.2019.101863

M3 - SCORING: Journal article

C2 - 31158692

VL - 23

SP - 101863

JO - NEUROIMAGE-CLIN

JF - NEUROIMAGE-CLIN

SN - 2213-1582

ER -