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Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials

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Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials. / Gharakhanlou, Reza; Wesselmann, Leonie; Rademacher, Annette; Lampit, Amit; Negaresh, Raoof; Kaviani, Mojtaba; Oberste, Max; Motl, Robert W; Sandroff, Brian M; Bansi, Jens; Baker, Julien S; Heesen, Christoph; Zimmer, Philipp; Javelle, Florian.

In: MULT SCLER J, Vol. 27, No. 13, 11.2021, p. 1977-1993.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Gharakhanlou, R, Wesselmann, L, Rademacher, A, Lampit, A, Negaresh, R, Kaviani, M, Oberste, M, Motl, RW, Sandroff, BM, Bansi, J, Baker, JS, Heesen, C, Zimmer, P & Javelle, F 2021, 'Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials', MULT SCLER J, vol. 27, no. 13, pp. 1977-1993. https://doi.org/10.1177/1352458520917935

APA

Gharakhanlou, R., Wesselmann, L., Rademacher, A., Lampit, A., Negaresh, R., Kaviani, M., Oberste, M., Motl, R. W., Sandroff, B. M., Bansi, J., Baker, J. S., Heesen, C., Zimmer, P., & Javelle, F. (2021). Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials. MULT SCLER J, 27(13), 1977-1993. https://doi.org/10.1177/1352458520917935

Vancouver

Gharakhanlou R, Wesselmann L, Rademacher A, Lampit A, Negaresh R, Kaviani M et al. Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials. MULT SCLER J. 2021 Nov;27(13):1977-1993. https://doi.org/10.1177/1352458520917935

Bibtex

@article{8d6d9237097848cd91af795664ce92a3,
title = "Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials",
abstract = "BACKGROUND: Cognitive impairment is common, debilitating, and poorly managed in persons with multiple sclerosis (pwMS). Exercise training might have positive effects on cognitive performance in pwMS, yet the overall magnitude, heterogeneity, and potential moderators remain unclear.OBJECTIVE: This three-level meta-analysis aims to identify the effects of exercise training and those of exercise modalities on global and domain-specific cognitive performance in pwMS.METHODS: MEDLINE, PsycInfo, SportDiscus, CENTRAL, and EMBASE were screened for randomized and non-randomized clinical trials from inception to 27 January 2020, yielding 3091 articles. Based on titles and abstracts, 75 articles remained in the selection process. After full-text evaluation, 13 studies were finally selected (PROSPERO pre-registered).RESULTS: The pooled effect of exercise training on the global cognitive performance was null (g = 0.04, 95% confidence interval (CI): -0.11 to 0.18) and no significant differences were displayed among domains. Heterogeneity within studies was null ( I ( 2 ) 2 = 0.0%) and between studies was low ( I ( 3 ) 2 = 25.1%). None of the moderators (exercise modalities, age, Expanded Disability Status Scale (EDSS), supervision, cognitive domains) reached significance. However, the exercise volume explained most of the overall heterogeneity (slope = 4.651 × 10-5, R ( 2 ) 2  = 100%, R ( 3 ) 2  = 52.34%).CONCLUSION: These results do not support the efficacy of exercise training on global or domain-specific cognitive performance in pwMS. Future studies are needed to determine whether higher training dose are beneficial.",
author = "Reza Gharakhanlou and Leonie Wesselmann and Annette Rademacher and Amit Lampit and Raoof Negaresh and Mojtaba Kaviani and Max Oberste and Motl, {Robert W} and Sandroff, {Brian M} and Jens Bansi and Baker, {Julien S} and Christoph Heesen and Philipp Zimmer and Florian Javelle",
year = "2021",
month = nov,
doi = "10.1177/1352458520917935",
language = "English",
volume = "27",
pages = "1977--1993",
journal = "MULT SCLER J",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "13",

}

RIS

TY - JOUR

T1 - Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials

AU - Gharakhanlou, Reza

AU - Wesselmann, Leonie

AU - Rademacher, Annette

AU - Lampit, Amit

AU - Negaresh, Raoof

AU - Kaviani, Mojtaba

AU - Oberste, Max

AU - Motl, Robert W

AU - Sandroff, Brian M

AU - Bansi, Jens

AU - Baker, Julien S

AU - Heesen, Christoph

AU - Zimmer, Philipp

AU - Javelle, Florian

PY - 2021/11

Y1 - 2021/11

N2 - BACKGROUND: Cognitive impairment is common, debilitating, and poorly managed in persons with multiple sclerosis (pwMS). Exercise training might have positive effects on cognitive performance in pwMS, yet the overall magnitude, heterogeneity, and potential moderators remain unclear.OBJECTIVE: This three-level meta-analysis aims to identify the effects of exercise training and those of exercise modalities on global and domain-specific cognitive performance in pwMS.METHODS: MEDLINE, PsycInfo, SportDiscus, CENTRAL, and EMBASE were screened for randomized and non-randomized clinical trials from inception to 27 January 2020, yielding 3091 articles. Based on titles and abstracts, 75 articles remained in the selection process. After full-text evaluation, 13 studies were finally selected (PROSPERO pre-registered).RESULTS: The pooled effect of exercise training on the global cognitive performance was null (g = 0.04, 95% confidence interval (CI): -0.11 to 0.18) and no significant differences were displayed among domains. Heterogeneity within studies was null ( I ( 2 ) 2 = 0.0%) and between studies was low ( I ( 3 ) 2 = 25.1%). None of the moderators (exercise modalities, age, Expanded Disability Status Scale (EDSS), supervision, cognitive domains) reached significance. However, the exercise volume explained most of the overall heterogeneity (slope = 4.651 × 10-5, R ( 2 ) 2  = 100%, R ( 3 ) 2  = 52.34%).CONCLUSION: These results do not support the efficacy of exercise training on global or domain-specific cognitive performance in pwMS. Future studies are needed to determine whether higher training dose are beneficial.

AB - BACKGROUND: Cognitive impairment is common, debilitating, and poorly managed in persons with multiple sclerosis (pwMS). Exercise training might have positive effects on cognitive performance in pwMS, yet the overall magnitude, heterogeneity, and potential moderators remain unclear.OBJECTIVE: This three-level meta-analysis aims to identify the effects of exercise training and those of exercise modalities on global and domain-specific cognitive performance in pwMS.METHODS: MEDLINE, PsycInfo, SportDiscus, CENTRAL, and EMBASE were screened for randomized and non-randomized clinical trials from inception to 27 January 2020, yielding 3091 articles. Based on titles and abstracts, 75 articles remained in the selection process. After full-text evaluation, 13 studies were finally selected (PROSPERO pre-registered).RESULTS: The pooled effect of exercise training on the global cognitive performance was null (g = 0.04, 95% confidence interval (CI): -0.11 to 0.18) and no significant differences were displayed among domains. Heterogeneity within studies was null ( I ( 2 ) 2 = 0.0%) and between studies was low ( I ( 3 ) 2 = 25.1%). None of the moderators (exercise modalities, age, Expanded Disability Status Scale (EDSS), supervision, cognitive domains) reached significance. However, the exercise volume explained most of the overall heterogeneity (slope = 4.651 × 10-5, R ( 2 ) 2  = 100%, R ( 3 ) 2  = 52.34%).CONCLUSION: These results do not support the efficacy of exercise training on global or domain-specific cognitive performance in pwMS. Future studies are needed to determine whether higher training dose are beneficial.

U2 - 10.1177/1352458520917935

DO - 10.1177/1352458520917935

M3 - SCORING: Review article

C2 - 32390502

VL - 27

SP - 1977

EP - 1993

JO - MULT SCLER J

JF - MULT SCLER J

SN - 1352-4585

IS - 13

ER -