Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required
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Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required. / Vorwerk, C K; Naskar, R; Schuettauf, F; Zurakowski, D; McDermott, L M; Quinto, K M; Dreyer, E B.
In: VET OPHTHALMOL, Vol. 4, No. 3, 09.2001, p. 201-4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required
AU - Vorwerk, C K
AU - Naskar, R
AU - Schuettauf, F
AU - Zurakowski, D
AU - McDermott, L M
AU - Quinto, K M
AU - Dreyer, E B
PY - 2001/9
Y1 - 2001/9
N2 - Axonal trauma leads to a series of pathologic events that can culminate in neuronal death. Although the precise mechanisms of retinal ganglion cell death after optic nerve crush in the rat model have not been elucidated, glutamate antagonists can protect retinal ganglion cells after optic nerve axotomy. We therefore explored whether a glutamate congener was toxic if applied directly within the optic nerve, or if toxicity depended upon an interaction at the cell body level. NMDA reduced retinal ganglion cell survival when applied directly into the rat optic nerve. Glutamate can be toxic if administered within the optic nerve; a direct effect at the cell body is not necessary. Future work will help to additionally unravel the steps by which axotomy induces excitotoxic damage to ganglion cells, and perhaps indicate protective interventions.
AB - Axonal trauma leads to a series of pathologic events that can culminate in neuronal death. Although the precise mechanisms of retinal ganglion cell death after optic nerve crush in the rat model have not been elucidated, glutamate antagonists can protect retinal ganglion cells after optic nerve axotomy. We therefore explored whether a glutamate congener was toxic if applied directly within the optic nerve, or if toxicity depended upon an interaction at the cell body level. NMDA reduced retinal ganglion cell survival when applied directly into the rat optic nerve. Glutamate can be toxic if administered within the optic nerve; a direct effect at the cell body is not necessary. Future work will help to additionally unravel the steps by which axotomy induces excitotoxic damage to ganglion cells, and perhaps indicate protective interventions.
KW - Animals
KW - Axotomy/veterinary
KW - Cell Survival/drug effects
KW - Excitatory Amino Acid Agonists/toxicity
KW - Excitatory Amino Acid Antagonists/pharmacology
KW - Memantine/pharmacology
KW - N-Methylaspartate/toxicity
KW - Nerve Crush
KW - Optic Nerve/drug effects
KW - Optic Nerve Injuries/pathology
KW - Rats
KW - Rats, Long-Evans
KW - Receptors, N-Methyl-D-Aspartate/physiology
KW - Retinal Ganglion Cells/drug effects
U2 - 10.1046/j.1463-5216.2001.00168.x
DO - 10.1046/j.1463-5216.2001.00168.x
M3 - SCORING: Journal article
C2 - 11722784
VL - 4
SP - 201
EP - 204
JO - VET OPHTHALMOL
JF - VET OPHTHALMOL
SN - 1463-5216
IS - 3
ER -