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Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing

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Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing. / Papanastasiou, Evangelos; Mouchlianitis, Elias; Joyce, Dan W; McGuire, Philip; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Spechler, Philip; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Artiges, Eric; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Poustka, Luise; Millenet, Sabina; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Shergill, Sukhwinder; IMAGEN Consortium.

In: JAMA PSYCHIAT, Vol. 75, No. 10, 01.10.2018, p. 1043-1051.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Papanastasiou, E, Mouchlianitis, E, Joyce, DW, McGuire, P, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Quinlan, EB, Desrivières, S, Flor, H, Frouin, V, Garavan, H, Spechler, P, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Paillère Martinot, M-L, Artiges, E, Nees, F, Papadopoulos Orfanos, D, Poustka, L, Millenet, S, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Shergill, S & IMAGEN Consortium 2018, 'Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing', JAMA PSYCHIAT, vol. 75, no. 10, pp. 1043-1051. https://doi.org/10.1001/jamapsychiatry.2018.1973

APA

Papanastasiou, E., Mouchlianitis, E., Joyce, D. W., McGuire, P., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Spechler, P., Gowland, P., Heinz, A., Ittermann, B., Martinot, J-L., Paillère Martinot, M-L., ... IMAGEN Consortium (2018). Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing. JAMA PSYCHIAT, 75(10), 1043-1051. https://doi.org/10.1001/jamapsychiatry.2018.1973

Vancouver

Papanastasiou E, Mouchlianitis E, Joyce DW, McGuire P, Banaschewski T, Bokde ALW et al. Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing. JAMA PSYCHIAT. 2018 Oct 1;75(10):1043-1051. https://doi.org/10.1001/jamapsychiatry.2018.1973

Bibtex

@article{fa8e849aec3642da97f42285463b270d,
title = "Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing",
abstract = "Importance: Psychoticlike experiences (PLEs) are subclinical manifestations of psychotic symptoms and may reflect an increased vulnerability to psychotic disorders. Contemporary models of psychosis propose that dysfunctional reward processing is involved in the cause of these clinical illnesses.Objective: To examine the neuroimaging profile of healthy adolescents at 14 and 19 years old points with PLEs, using a reward task.Design, Setting, and Participants: A community-based cohort study, using both a cross-sectional and longitudinal design, was conducted in academic centers in London, Nottingham, United Kingdom, and Dublin, Ireland; Paris, France; and Berlin, Hamburg, Mannheim, and Dresden, Germany. A group of 1434 healthy adolescent volunteers was evaluated, and 2 subgroups were assessed at ages 14 and 19 years. Those who scored as either high or low PLE (based on the upper and lower deciles) on the Community Assessment of Psychic Experiences Questionnaire (CAPE-42) at age 19 years were included in the analysis. The study was conducted from January 1, 2016, to January 1, 2017.Main Outcomes and Measures: Participants were assessed at age 14 and 19 year points using functional magnetic resonance imaging while performing a monetary incentive delay reward task. A first-level model focused on 2 predefined contrasts of anticipation and feedback of a win. The second-level analysis examined activation within the reward network using an a priori-defined region of interest approach. The main effects of group, time, and their interaction on brain activation were examined.Results: Of the 1434 adolescents, 2 groups (n = 149 each) (high PLEs, n = 149, 50 [33.6%] male; low PLEs, n = 149, 84 [56.4%] male) were compared at ages 14 and 19 years. Two regions within the left and right middle frontal gyri showed a main effect of time on brain activation (F1, 93 = 5.559; P = .02; F1, 93 = 5.009; P = .03, respectively); there was no main effect of group. One region within the right middle frontal gyrus demonstrated a significant time × group interaction (F1, 93 = 7.448; P = .01).Conclusion and Relevance: The findings are consistent with evidence implicating alterations in prefrontal and striatal function during reward processing in the etiology of psychosis. Given the nature of this nonclinical sample this may reflect a combination of aberrant salience yielding abnormal experiences and a compensatory cognitive control mechanism necessary to contextualize them.",
author = "Evangelos Papanastasiou and Elias Mouchlianitis and Joyce, {Dan W} and Philip McGuire and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin Burke} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Hugh Garavan and Philip Spechler and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and {Paill{\`e}re Martinot}, Marie-Laure and Eric Artiges and Frauke Nees and {Papadopoulos Orfanos}, Dimitri and Luise Poustka and Sabina Millenet and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann and Sukhwinder Shergill and {IMAGEN Consortium}",
year = "2018",
month = oct,
day = "1",
doi = "10.1001/jamapsychiatry.2018.1973",
language = "English",
volume = "75",
pages = "1043--1051",
journal = "JAMA PSYCHIAT",
issn = "2168-622X",
publisher = "American Medical Association",
number = "10",

}

RIS

TY - JOUR

T1 - Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing

AU - Papanastasiou, Evangelos

AU - Mouchlianitis, Elias

AU - Joyce, Dan W

AU - McGuire, Philip

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Spechler, Philip

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Paillère Martinot, Marie-Laure

AU - Artiges, Eric

AU - Nees, Frauke

AU - Papadopoulos Orfanos, Dimitri

AU - Poustka, Luise

AU - Millenet, Sabina

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Shergill, Sukhwinder

AU - IMAGEN Consortium

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Importance: Psychoticlike experiences (PLEs) are subclinical manifestations of psychotic symptoms and may reflect an increased vulnerability to psychotic disorders. Contemporary models of psychosis propose that dysfunctional reward processing is involved in the cause of these clinical illnesses.Objective: To examine the neuroimaging profile of healthy adolescents at 14 and 19 years old points with PLEs, using a reward task.Design, Setting, and Participants: A community-based cohort study, using both a cross-sectional and longitudinal design, was conducted in academic centers in London, Nottingham, United Kingdom, and Dublin, Ireland; Paris, France; and Berlin, Hamburg, Mannheim, and Dresden, Germany. A group of 1434 healthy adolescent volunteers was evaluated, and 2 subgroups were assessed at ages 14 and 19 years. Those who scored as either high or low PLE (based on the upper and lower deciles) on the Community Assessment of Psychic Experiences Questionnaire (CAPE-42) at age 19 years were included in the analysis. The study was conducted from January 1, 2016, to January 1, 2017.Main Outcomes and Measures: Participants were assessed at age 14 and 19 year points using functional magnetic resonance imaging while performing a monetary incentive delay reward task. A first-level model focused on 2 predefined contrasts of anticipation and feedback of a win. The second-level analysis examined activation within the reward network using an a priori-defined region of interest approach. The main effects of group, time, and their interaction on brain activation were examined.Results: Of the 1434 adolescents, 2 groups (n = 149 each) (high PLEs, n = 149, 50 [33.6%] male; low PLEs, n = 149, 84 [56.4%] male) were compared at ages 14 and 19 years. Two regions within the left and right middle frontal gyri showed a main effect of time on brain activation (F1, 93 = 5.559; P = .02; F1, 93 = 5.009; P = .03, respectively); there was no main effect of group. One region within the right middle frontal gyrus demonstrated a significant time × group interaction (F1, 93 = 7.448; P = .01).Conclusion and Relevance: The findings are consistent with evidence implicating alterations in prefrontal and striatal function during reward processing in the etiology of psychosis. Given the nature of this nonclinical sample this may reflect a combination of aberrant salience yielding abnormal experiences and a compensatory cognitive control mechanism necessary to contextualize them.

AB - Importance: Psychoticlike experiences (PLEs) are subclinical manifestations of psychotic symptoms and may reflect an increased vulnerability to psychotic disorders. Contemporary models of psychosis propose that dysfunctional reward processing is involved in the cause of these clinical illnesses.Objective: To examine the neuroimaging profile of healthy adolescents at 14 and 19 years old points with PLEs, using a reward task.Design, Setting, and Participants: A community-based cohort study, using both a cross-sectional and longitudinal design, was conducted in academic centers in London, Nottingham, United Kingdom, and Dublin, Ireland; Paris, France; and Berlin, Hamburg, Mannheim, and Dresden, Germany. A group of 1434 healthy adolescent volunteers was evaluated, and 2 subgroups were assessed at ages 14 and 19 years. Those who scored as either high or low PLE (based on the upper and lower deciles) on the Community Assessment of Psychic Experiences Questionnaire (CAPE-42) at age 19 years were included in the analysis. The study was conducted from January 1, 2016, to January 1, 2017.Main Outcomes and Measures: Participants were assessed at age 14 and 19 year points using functional magnetic resonance imaging while performing a monetary incentive delay reward task. A first-level model focused on 2 predefined contrasts of anticipation and feedback of a win. The second-level analysis examined activation within the reward network using an a priori-defined region of interest approach. The main effects of group, time, and their interaction on brain activation were examined.Results: Of the 1434 adolescents, 2 groups (n = 149 each) (high PLEs, n = 149, 50 [33.6%] male; low PLEs, n = 149, 84 [56.4%] male) were compared at ages 14 and 19 years. Two regions within the left and right middle frontal gyri showed a main effect of time on brain activation (F1, 93 = 5.559; P = .02; F1, 93 = 5.009; P = .03, respectively); there was no main effect of group. One region within the right middle frontal gyrus demonstrated a significant time × group interaction (F1, 93 = 7.448; P = .01).Conclusion and Relevance: The findings are consistent with evidence implicating alterations in prefrontal and striatal function during reward processing in the etiology of psychosis. Given the nature of this nonclinical sample this may reflect a combination of aberrant salience yielding abnormal experiences and a compensatory cognitive control mechanism necessary to contextualize them.

U2 - 10.1001/jamapsychiatry.2018.1973

DO - 10.1001/jamapsychiatry.2018.1973

M3 - SCORING: Journal article

C2 - 30073329

VL - 75

SP - 1043

EP - 1051

JO - JAMA PSYCHIAT

JF - JAMA PSYCHIAT

SN - 2168-622X

IS - 10

ER -