Exacerbation of hepatitis E virus infection during anti-TNFα treatment

Patrick Behrendt; Stefan Lüth; Werner Dammermann; Svenja Drave; Richard J P Brown; Daniel Todt; Ulrike Schnoor; Eike Steinmann; Heiner Wedemeyer; Sven Pischke; Christof Iking-Konert

doi:10.1016/j.jbspin.2016.09.017

Exacerbation of hepatitis E virus infection during anti-TNFα treatment

Standard

Exacerbation of hepatitis E virus infection during anti-TNFα treatment. / Behrendt, Patrick; Lüth, Stefan; Dammermann, Werner; Drave, Svenja; Brown, Richard J P; Todt, Daniel; Schnoor, Ulrike; Steinmann, Eike; Wedemeyer, Heiner; Pischke, Sven ; Iking-Konert, Christof.

In: JOINT BONE SPINE, Vol. 84, No. 2, 03.2017, p. 217-219.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Behrendt, P, Lüth, S, Dammermann, W, Drave, S, Brown, RJP, Todt, D, Schnoor, U, Steinmann, E, Wedemeyer, H, Pischke, S & Iking-Konert, C 2017, 'Exacerbation of hepatitis E virus infection during anti-TNFα treatment', JOINT BONE SPINE, vol. 84, no. 2, pp. 217-219. https://doi.org/10.1016/j.jbspin.2016.09.017

APA

Behrendt, P., Lüth, S., Dammermann, W., Drave, S., Brown, R. J. P., Todt, D., Schnoor, U., Steinmann, E., Wedemeyer, H., Pischke, S., & Iking-Konert, C. (2017). Exacerbation of hepatitis E virus infection during anti-TNFα treatment. JOINT BONE SPINE, 84(2), 217-219. https://doi.org/10.1016/j.jbspin.2016.09.017

Vancouver

Behrendt P, Lüth S, Dammermann W, Drave S, Brown RJP, Todt D et al. Exacerbation of hepatitis E virus infection during anti-TNFα treatment. JOINT BONE SPINE. 2017 Mar;84(2):217-219. https://doi.org/10.1016/j.jbspin.2016.09.017

Bibtex

@article{64e5580ec35c4e56acec1675585842e8,

title = "Exacerbation of hepatitis E virus infection during anti-TNFα treatment",

abstract = "Chronic hepatitis E virus (HEV) infection may occur in immunocompromised patients. Previous studies report that different immunosuppressive agents interfere with viral replication. However, the role of TNFα in HEV infection is currently unknown. Here, we describe a case of severe exacerbation of a chronic HEV infection in a patient undergoing treatment with a TNFα-inhibitor for psoriatic arthritis despite potent anti-HEV T-cell responses. We used state-of-the-art HEV cell culture methods to test antiviral effects of different drugs and a cytokine release assay to assess HEV specific T cell immunity. In addition standard tools of our diagnostics laboratory were employed. In vitro data confirmed inhibition of HEV replication by TNFα, which could be abolished by addition of TNFα inhibitors. Thus, TNFα may play a critical role in the control of HEV replication. We therefore recommend exclusion of HEV infection prior to initiation of TNFα-inhibitor therapy.",

author = "Patrick Behrendt and Stefan L{\"u}th and Werner Dammermann and Svenja Drave and Brown, {Richard J P} and Daniel Todt and Ulrike Schnoor and Eike Steinmann and Heiner Wedemeyer and Sven Pischke and Christof Iking-Konert",

year = "2017",

month = mar,

doi = "10.1016/j.jbspin.2016.09.017",

language = "English",

volume = "84",

pages = "217--219",

journal = "JOINT BONE SPINE",

issn = "1297-319X",

publisher = "Elsevier Masson",

number = "2",

}

RIS

TY - JOUR

T1 - Exacerbation of hepatitis E virus infection during anti-TNFα treatment

AU - Behrendt, Patrick

AU - Lüth, Stefan

AU - Dammermann, Werner

AU - Drave, Svenja

AU - Brown, Richard J P

AU - Todt, Daniel

AU - Schnoor, Ulrike

AU - Steinmann, Eike

AU - Wedemeyer, Heiner

AU - Pischke, Sven

AU - Iking-Konert, Christof

PY - 2017/3

Y1 - 2017/3

N2 - Chronic hepatitis E virus (HEV) infection may occur in immunocompromised patients. Previous studies report that different immunosuppressive agents interfere with viral replication. However, the role of TNFα in HEV infection is currently unknown. Here, we describe a case of severe exacerbation of a chronic HEV infection in a patient undergoing treatment with a TNFα-inhibitor for psoriatic arthritis despite potent anti-HEV T-cell responses. We used state-of-the-art HEV cell culture methods to test antiviral effects of different drugs and a cytokine release assay to assess HEV specific T cell immunity. In addition standard tools of our diagnostics laboratory were employed. In vitro data confirmed inhibition of HEV replication by TNFα, which could be abolished by addition of TNFα inhibitors. Thus, TNFα may play a critical role in the control of HEV replication. We therefore recommend exclusion of HEV infection prior to initiation of TNFα-inhibitor therapy.

AB - Chronic hepatitis E virus (HEV) infection may occur in immunocompromised patients. Previous studies report that different immunosuppressive agents interfere with viral replication. However, the role of TNFα in HEV infection is currently unknown. Here, we describe a case of severe exacerbation of a chronic HEV infection in a patient undergoing treatment with a TNFα-inhibitor for psoriatic arthritis despite potent anti-HEV T-cell responses. We used state-of-the-art HEV cell culture methods to test antiviral effects of different drugs and a cytokine release assay to assess HEV specific T cell immunity. In addition standard tools of our diagnostics laboratory were employed. In vitro data confirmed inhibition of HEV replication by TNFα, which could be abolished by addition of TNFα inhibitors. Thus, TNFα may play a critical role in the control of HEV replication. We therefore recommend exclusion of HEV infection prior to initiation of TNFα-inhibitor therapy.

U2 - 10.1016/j.jbspin.2016.09.017

DO - 10.1016/j.jbspin.2016.09.017

M3 - SCORING: Journal article

C2 - 27836355

VL - 84

SP - 217

EP - 219

JO - JOINT BONE SPINE

JF - JOINT BONE SPINE

SN - 1297-319X

IS - 2

ER -