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Ewing sarcoma during follow-up

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Ewing sarcoma during follow-up : The value of a predefined imaging protocol including FDG-PET/CT for the detection of tumour recurrence. / Heinemann, Melina; Ranft, Andreas; Jürgens, Heribert; Langer, Thorsten; Vieth, Volker; Timmermann, Beate; Weckesser, Matthias; Dirksen, Uta; Stegger, Lars.

In: NUKLEARMED-NUCL MED, Vol. 56, No. 6, 2017, p. 233-238.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Heinemann, M, Ranft, A, Jürgens, H, Langer, T, Vieth, V, Timmermann, B, Weckesser, M, Dirksen, U & Stegger, L 2017, 'Ewing sarcoma during follow-up: The value of a predefined imaging protocol including FDG-PET/CT for the detection of tumour recurrence', NUKLEARMED-NUCL MED, vol. 56, no. 6, pp. 233-238. https://doi.org/10.3413/Nukmed-0909-17-07

APA

Heinemann, M., Ranft, A., Jürgens, H., Langer, T., Vieth, V., Timmermann, B., Weckesser, M., Dirksen, U., & Stegger, L. (2017). Ewing sarcoma during follow-up: The value of a predefined imaging protocol including FDG-PET/CT for the detection of tumour recurrence. NUKLEARMED-NUCL MED, 56(6), 233-238. https://doi.org/10.3413/Nukmed-0909-17-07

Vancouver

Heinemann M, Ranft A, Jürgens H, Langer T, Vieth V, Timmermann B et al. Ewing sarcoma during follow-up: The value of a predefined imaging protocol including FDG-PET/CT for the detection of tumour recurrence. NUKLEARMED-NUCL MED. 2017;56(6):233-238. https://doi.org/10.3413/Nukmed-0909-17-07

Bibtex

@article{deb5a26e8857409ea0bbad2aacfae14a,
title = "Ewing sarcoma during follow-up: The value of a predefined imaging protocol including FDG-PET/CT for the detection of tumour recurrence",
abstract = "AIM: To evaluate the performance of a prospectively defined follow-up imaging protocol that includes FDG-PET(/CT) to detect tumour recurrence in Ewing sarcoma (EwS) before becoming symptomatic.METHODS: Imaging results and clinical data during follow-up were retrospectively analysed from all patients treated successfully within the EURO E.W.I.N.G. 99 trial at the University Hospital M{\"u}nster, Germany. All patients received follow-up imaging according to a comprehensive protocol that included regular X-ray, CT, MRI, bone scan and PET(/CT), albeit not all on the same day and with varying intervals for the different modalities.RESULTS: 80 of 105 patients underwent follow-up at our institution after complete remission. 30 patients had recurrent tumour during the follow-up period of 3.6 years on average. 19 recurrences (63%) were detected by scheduled imaging before the advent of clinical symptoms. The majority of these recurrences (8 out of 19; 42%) was detected first by PET/ CT (and confirmed with additional imaging thereafter), even though the total number of PET/CTs was comparatively low (138) and PET/CT was not systematically scheduled before other imaging techniques. Recurrences detected by bone scan were also detectable by PET.CONCLUSIONS: The implemented follow-up protocol was effective in the detection of EwS recurrence before the advent of symptoms. Most cases of those detected before onset of symptoms were detected by PET/CT first. This hybrid imaging modality should therefore be considered in the routine follow-up of EwS patients, as is standard in our hospital. In combination with PET, low-dose chest CT seems to be sufficient in the detection of small pulmonary nodules.",
keywords = "Adolescent, Adult, Bone Neoplasms, Child, Child, Preschool, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Multimodal Imaging, Positron Emission Tomography Computed Tomography, Prospective Studies, Radiography, Radiopharmaceuticals, Recurrence, Remission Induction, Retrospective Studies, Sarcoma, Ewing, Young Adult, Clinical Trial, Journal Article",
author = "Melina Heinemann and Andreas Ranft and Heribert J{\"u}rgens and Thorsten Langer and Volker Vieth and Beate Timmermann and Matthias Weckesser and Uta Dirksen and Lars Stegger",
note = "Schattauer GmbH.",
year = "2017",
doi = "10.3413/Nukmed-0909-17-07",
language = "English",
volume = "56",
pages = "233--238",
journal = "NUKLEARMED-NUCL MED",
issn = "0029-5566",
publisher = "Schattauer",
number = "6",

}

RIS

TY - JOUR

T1 - Ewing sarcoma during follow-up

T2 - The value of a predefined imaging protocol including FDG-PET/CT for the detection of tumour recurrence

AU - Heinemann, Melina

AU - Ranft, Andreas

AU - Jürgens, Heribert

AU - Langer, Thorsten

AU - Vieth, Volker

AU - Timmermann, Beate

AU - Weckesser, Matthias

AU - Dirksen, Uta

AU - Stegger, Lars

N1 - Schattauer GmbH.

PY - 2017

Y1 - 2017

N2 - AIM: To evaluate the performance of a prospectively defined follow-up imaging protocol that includes FDG-PET(/CT) to detect tumour recurrence in Ewing sarcoma (EwS) before becoming symptomatic.METHODS: Imaging results and clinical data during follow-up were retrospectively analysed from all patients treated successfully within the EURO E.W.I.N.G. 99 trial at the University Hospital Münster, Germany. All patients received follow-up imaging according to a comprehensive protocol that included regular X-ray, CT, MRI, bone scan and PET(/CT), albeit not all on the same day and with varying intervals for the different modalities.RESULTS: 80 of 105 patients underwent follow-up at our institution after complete remission. 30 patients had recurrent tumour during the follow-up period of 3.6 years on average. 19 recurrences (63%) were detected by scheduled imaging before the advent of clinical symptoms. The majority of these recurrences (8 out of 19; 42%) was detected first by PET/ CT (and confirmed with additional imaging thereafter), even though the total number of PET/CTs was comparatively low (138) and PET/CT was not systematically scheduled before other imaging techniques. Recurrences detected by bone scan were also detectable by PET.CONCLUSIONS: The implemented follow-up protocol was effective in the detection of EwS recurrence before the advent of symptoms. Most cases of those detected before onset of symptoms were detected by PET/CT first. This hybrid imaging modality should therefore be considered in the routine follow-up of EwS patients, as is standard in our hospital. In combination with PET, low-dose chest CT seems to be sufficient in the detection of small pulmonary nodules.

AB - AIM: To evaluate the performance of a prospectively defined follow-up imaging protocol that includes FDG-PET(/CT) to detect tumour recurrence in Ewing sarcoma (EwS) before becoming symptomatic.METHODS: Imaging results and clinical data during follow-up were retrospectively analysed from all patients treated successfully within the EURO E.W.I.N.G. 99 trial at the University Hospital Münster, Germany. All patients received follow-up imaging according to a comprehensive protocol that included regular X-ray, CT, MRI, bone scan and PET(/CT), albeit not all on the same day and with varying intervals for the different modalities.RESULTS: 80 of 105 patients underwent follow-up at our institution after complete remission. 30 patients had recurrent tumour during the follow-up period of 3.6 years on average. 19 recurrences (63%) were detected by scheduled imaging before the advent of clinical symptoms. The majority of these recurrences (8 out of 19; 42%) was detected first by PET/ CT (and confirmed with additional imaging thereafter), even though the total number of PET/CTs was comparatively low (138) and PET/CT was not systematically scheduled before other imaging techniques. Recurrences detected by bone scan were also detectable by PET.CONCLUSIONS: The implemented follow-up protocol was effective in the detection of EwS recurrence before the advent of symptoms. Most cases of those detected before onset of symptoms were detected by PET/CT first. This hybrid imaging modality should therefore be considered in the routine follow-up of EwS patients, as is standard in our hospital. In combination with PET, low-dose chest CT seems to be sufficient in the detection of small pulmonary nodules.

KW - Adolescent

KW - Adult

KW - Bone Neoplasms

KW - Child

KW - Child, Preschool

KW - Female

KW - Fluorodeoxyglucose F18

KW - Follow-Up Studies

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Multimodal Imaging

KW - Positron Emission Tomography Computed Tomography

KW - Prospective Studies

KW - Radiography

KW - Radiopharmaceuticals

KW - Recurrence

KW - Remission Induction

KW - Retrospective Studies

KW - Sarcoma, Ewing

KW - Young Adult

KW - Clinical Trial

KW - Journal Article

U2 - 10.3413/Nukmed-0909-17-07

DO - 10.3413/Nukmed-0909-17-07

M3 - SCORING: Journal article

C2 - 29533418

VL - 56

SP - 233

EP - 238

JO - NUKLEARMED-NUCL MED

JF - NUKLEARMED-NUCL MED

SN - 0029-5566

IS - 6

ER -