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Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis

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Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis. / Körber, Verena; Yang, Jing; Barah, Pankaj; Wu, Yonghe; Stichel, Damian; Gu, Zuguang; Fletcher, Michael Nai Chung; Jones, David; Hentschel, Bettina; Lamszus, Katrin; Tonn, Jörg Christian; Schackert, Gabriele; Sabel, Michael; Felsberg, Jörg; Zacher, Angela; Kaulich, Kerstin; Hübschmann, Daniel; Herold-Mende, Christel; von Deimling, Andreas; Weller, Michael; Radlwimmer, Bernhard; Schlesner, Matthias; Reifenberger, Guido; Höfer, Thomas; Lichter, Peter.

In: CANCER CELL, Vol. 35, No. 4, 15.04.2019, p. 692-704.e12.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Körber, V, Yang, J, Barah, P, Wu, Y, Stichel, D, Gu, Z, Fletcher, MNC, Jones, D, Hentschel, B, Lamszus, K, Tonn, JC, Schackert, G, Sabel, M, Felsberg, J, Zacher, A, Kaulich, K, Hübschmann, D, Herold-Mende, C, von Deimling, A, Weller, M, Radlwimmer, B, Schlesner, M, Reifenberger, G, Höfer, T & Lichter, P 2019, 'Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis', CANCER CELL, vol. 35, no. 4, pp. 692-704.e12. https://doi.org/10.1016/j.ccell.2019.02.007

APA

Körber, V., Yang, J., Barah, P., Wu, Y., Stichel, D., Gu, Z., Fletcher, M. N. C., Jones, D., Hentschel, B., Lamszus, K., Tonn, J. C., Schackert, G., Sabel, M., Felsberg, J., Zacher, A., Kaulich, K., Hübschmann, D., Herold-Mende, C., von Deimling, A., ... Lichter, P. (2019). Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis. CANCER CELL, 35(4), 692-704.e12. https://doi.org/10.1016/j.ccell.2019.02.007

Vancouver

Körber V, Yang J, Barah P, Wu Y, Stichel D, Gu Z et al. Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis. CANCER CELL. 2019 Apr 15;35(4):692-704.e12. https://doi.org/10.1016/j.ccell.2019.02.007

Bibtex

@article{55154abba1aa47dbbcb18b9c9cec462c,
title = "Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis",
abstract = "We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. We inferred the evolutionary trajectories of matched pairs of primary and relapsed tumors based on deep whole-genome-sequencing data. This analysis suggests both a distant origin of de novo glioblastoma, up to 7 years before diagnosis, and a common path of early tumorigenesis, with one or more of chromosome 7 gain, 9p loss, or 10 loss, at tumor initiation. TERT promoter mutations often occurred later as a prerequisite for rapid growth. In contrast to this common early path, relapsed tumors acquired no stereotypical pattern of mutations and typically regrew from oligoclonal origins, suggesting sparse selective pressure by therapeutic measures.",
author = "Verena K{\"o}rber and Jing Yang and Pankaj Barah and Yonghe Wu and Damian Stichel and Zuguang Gu and Fletcher, {Michael Nai Chung} and David Jones and Bettina Hentschel and Katrin Lamszus and Tonn, {J{\"o}rg Christian} and Gabriele Schackert and Michael Sabel and J{\"o}rg Felsberg and Angela Zacher and Kerstin Kaulich and Daniel H{\"u}bschmann and Christel Herold-Mende and {von Deimling}, Andreas and Michael Weller and Bernhard Radlwimmer and Matthias Schlesner and Guido Reifenberger and Thomas H{\"o}fer and Peter Lichter",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = apr,
day = "15",
doi = "10.1016/j.ccell.2019.02.007",
language = "English",
volume = "35",
pages = "692--704.e12",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis

AU - Körber, Verena

AU - Yang, Jing

AU - Barah, Pankaj

AU - Wu, Yonghe

AU - Stichel, Damian

AU - Gu, Zuguang

AU - Fletcher, Michael Nai Chung

AU - Jones, David

AU - Hentschel, Bettina

AU - Lamszus, Katrin

AU - Tonn, Jörg Christian

AU - Schackert, Gabriele

AU - Sabel, Michael

AU - Felsberg, Jörg

AU - Zacher, Angela

AU - Kaulich, Kerstin

AU - Hübschmann, Daniel

AU - Herold-Mende, Christel

AU - von Deimling, Andreas

AU - Weller, Michael

AU - Radlwimmer, Bernhard

AU - Schlesner, Matthias

AU - Reifenberger, Guido

AU - Höfer, Thomas

AU - Lichter, Peter

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/4/15

Y1 - 2019/4/15

N2 - We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. We inferred the evolutionary trajectories of matched pairs of primary and relapsed tumors based on deep whole-genome-sequencing data. This analysis suggests both a distant origin of de novo glioblastoma, up to 7 years before diagnosis, and a common path of early tumorigenesis, with one or more of chromosome 7 gain, 9p loss, or 10 loss, at tumor initiation. TERT promoter mutations often occurred later as a prerequisite for rapid growth. In contrast to this common early path, relapsed tumors acquired no stereotypical pattern of mutations and typically regrew from oligoclonal origins, suggesting sparse selective pressure by therapeutic measures.

AB - We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. We inferred the evolutionary trajectories of matched pairs of primary and relapsed tumors based on deep whole-genome-sequencing data. This analysis suggests both a distant origin of de novo glioblastoma, up to 7 years before diagnosis, and a common path of early tumorigenesis, with one or more of chromosome 7 gain, 9p loss, or 10 loss, at tumor initiation. TERT promoter mutations often occurred later as a prerequisite for rapid growth. In contrast to this common early path, relapsed tumors acquired no stereotypical pattern of mutations and typically regrew from oligoclonal origins, suggesting sparse selective pressure by therapeutic measures.

U2 - 10.1016/j.ccell.2019.02.007

DO - 10.1016/j.ccell.2019.02.007

M3 - SCORING: Journal article

C2 - 30905762

VL - 35

SP - 692-704.e12

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 4

ER -