Research ExplorerPublicationsEvolution of retinal degeneration and prediction of disease ...

Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

Standard

Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis. / Krämer, Julia; Balloff, Carolin; Weise, Margit; Koska, Valeria; Uthmeier, Yannik; Esderts, Isabell; Nguyen-Minh, Mai; Zimmerhof, Moritz; Hartmann, Alex; Dietrich, Michael; Ingwersen, Jens; Lee, John-Ih; Havla, Joachim; Kümpfel, Tania; Kerschensteiner, Martin; Häußler, Vivien; Heesen, Christoph; Stellmann, Jan-Patrick; Zimmermann, Hanna G; Oertel, Frederike C; Ringelstein, Marius; Brandt, Alexander U; Paul, Friedemann; Aktas, Orhan; Hartung, Hans-Peter; Wiendl, Heinz; Meuth, Sven G; Albrecht, Philipp.

In: NAT COMMUN, Vol. 15, No. 1, 19.06.2024, p. 5243.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Krämer, J, Balloff, C, Weise, M, Koska, V, Uthmeier, Y, Esderts, I, Nguyen-Minh, M, Zimmerhof, M, Hartmann, A, Dietrich, M, Ingwersen, J, Lee, J-I, Havla, J, Kümpfel, T, Kerschensteiner, M, Häußler, V, Heesen, C, Stellmann, J-P, Zimmermann, HG, Oertel, FC, Ringelstein, M, Brandt, AU, Paul, F, Aktas, O, Hartung, H-P, Wiendl, H, Meuth, SG & Albrecht, P 2024, 'Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis', NAT COMMUN, vol. 15, no. 1, pp. 5243. https://doi.org/10.1038/s41467-024-49309-7

APA

Krämer, J., Balloff, C., Weise, M., Koska, V., Uthmeier, Y., Esderts, I., Nguyen-Minh, M., Zimmerhof, M., Hartmann, A., Dietrich, M., Ingwersen, J., Lee, J-I., Havla, J., Kümpfel, T., Kerschensteiner, M., Häußler, V., Heesen, C., Stellmann, J-P., Zimmermann, H. G., ... Albrecht, P. (2024). Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis. NAT COMMUN, 15(1), 5243. https://doi.org/10.1038/s41467-024-49309-7

Vancouver

Krämer J, Balloff C, Weise M, Koska V, Uthmeier Y, Esderts I et al. Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis. NAT COMMUN. 2024 Jun 19;15(1):5243. https://doi.org/10.1038/s41467-024-49309-7

Bibtex

@article{9f22decd83a14298bc84c3050817225a,
title = "Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis",
abstract = "Retinal optical coherence tomography has been identified as biomarker for disease progression in relapsing-remitting multiple sclerosis (RRMS), while the dynamics of retinal atrophy in progressive MS are less clear. We investigated retinal layer thickness changes in RRMS, primary and secondary progressive MS (PPMS, SPMS), and their prognostic value for disease activity. Here, we analyzed 2651 OCT measurements of 195 RRMS, 87 SPMS, 125 PPMS patients, and 98 controls from five German MS centers after quality control. Peripapillary and macular retinal nerve fiber layer (pRNFL, mRNFL) thickness predicted future relapses in all MS and RRMS patients while mRNFL and ganglion cell-inner plexiform layer (GCIPL) thickness predicted future MRI activity in RRMS (mRNFL, GCIPL) and PPMS (GCIPL). mRNFL thickness predicted future disability progression in PPMS. However, thickness change rates were subject to considerable amounts of measurement variability. In conclusion, retinal degeneration, most pronounced of pRNFL and GCIPL, occurs in all subtypes. Using the current state of technology, longitudinal assessments of retinal thickness may not be suitable on a single patient level.",
keywords = "Humans, Retinal Degeneration/diagnostic imaging, Male, Female, Tomography, Optical Coherence/methods, Adult, Middle Aged, Disease Progression, Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging, Retina/diagnostic imaging, Multiple Sclerosis, Chronic Progressive/diagnostic imaging, Magnetic Resonance Imaging/methods, Prognosis, Nerve Fibers/pathology, Retinal Ganglion Cells/pathology",
author = "Julia Kr{\"a}mer and Carolin Balloff and Margit Weise and Valeria Koska and Yannik Uthmeier and Isabell Esderts and Mai Nguyen-Minh and Moritz Zimmerhof and Alex Hartmann and Michael Dietrich and Jens Ingwersen and John-Ih Lee and Joachim Havla and Tania K{\"u}mpfel and Martin Kerschensteiner and Vivien H{\"a}u{\ss}ler and Christoph Heesen and Jan-Patrick Stellmann and Zimmermann, {Hanna G} and Oertel, {Frederike C} and Marius Ringelstein and Brandt, {Alexander U} and Friedemann Paul and Orhan Aktas and Hans-Peter Hartung and Heinz Wiendl and Meuth, {Sven G} and Philipp Albrecht",
note = "{\textcopyright} 2024. The Author(s).",
year = "2024",
month = jun,
day = "19",
doi = "10.1038/s41467-024-49309-7",
language = "English",
volume = "15",
pages = "5243",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

AU - Krämer, Julia

AU - Balloff, Carolin

AU - Weise, Margit

AU - Koska, Valeria

AU - Uthmeier, Yannik

AU - Esderts, Isabell

AU - Nguyen-Minh, Mai

AU - Zimmerhof, Moritz

AU - Hartmann, Alex

AU - Dietrich, Michael

AU - Ingwersen, Jens

AU - Lee, John-Ih

AU - Havla, Joachim

AU - Kümpfel, Tania

AU - Kerschensteiner, Martin

AU - Häußler, Vivien

AU - Heesen, Christoph

AU - Stellmann, Jan-Patrick

AU - Zimmermann, Hanna G

AU - Oertel, Frederike C

AU - Ringelstein, Marius

AU - Brandt, Alexander U

AU - Paul, Friedemann

AU - Aktas, Orhan

AU - Hartung, Hans-Peter

AU - Wiendl, Heinz

AU - Meuth, Sven G

AU - Albrecht, Philipp

N1 - © 2024. The Author(s).

PY - 2024/6/19

Y1 - 2024/6/19

N2 - Retinal optical coherence tomography has been identified as biomarker for disease progression in relapsing-remitting multiple sclerosis (RRMS), while the dynamics of retinal atrophy in progressive MS are less clear. We investigated retinal layer thickness changes in RRMS, primary and secondary progressive MS (PPMS, SPMS), and their prognostic value for disease activity. Here, we analyzed 2651 OCT measurements of 195 RRMS, 87 SPMS, 125 PPMS patients, and 98 controls from five German MS centers after quality control. Peripapillary and macular retinal nerve fiber layer (pRNFL, mRNFL) thickness predicted future relapses in all MS and RRMS patients while mRNFL and ganglion cell-inner plexiform layer (GCIPL) thickness predicted future MRI activity in RRMS (mRNFL, GCIPL) and PPMS (GCIPL). mRNFL thickness predicted future disability progression in PPMS. However, thickness change rates were subject to considerable amounts of measurement variability. In conclusion, retinal degeneration, most pronounced of pRNFL and GCIPL, occurs in all subtypes. Using the current state of technology, longitudinal assessments of retinal thickness may not be suitable on a single patient level.

AB - Retinal optical coherence tomography has been identified as biomarker for disease progression in relapsing-remitting multiple sclerosis (RRMS), while the dynamics of retinal atrophy in progressive MS are less clear. We investigated retinal layer thickness changes in RRMS, primary and secondary progressive MS (PPMS, SPMS), and their prognostic value for disease activity. Here, we analyzed 2651 OCT measurements of 195 RRMS, 87 SPMS, 125 PPMS patients, and 98 controls from five German MS centers after quality control. Peripapillary and macular retinal nerve fiber layer (pRNFL, mRNFL) thickness predicted future relapses in all MS and RRMS patients while mRNFL and ganglion cell-inner plexiform layer (GCIPL) thickness predicted future MRI activity in RRMS (mRNFL, GCIPL) and PPMS (GCIPL). mRNFL thickness predicted future disability progression in PPMS. However, thickness change rates were subject to considerable amounts of measurement variability. In conclusion, retinal degeneration, most pronounced of pRNFL and GCIPL, occurs in all subtypes. Using the current state of technology, longitudinal assessments of retinal thickness may not be suitable on a single patient level.

KW - Humans

KW - Retinal Degeneration/diagnostic imaging

KW - Male

KW - Female

KW - Tomography, Optical Coherence/methods

KW - Adult

KW - Middle Aged

KW - Disease Progression

KW - Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging

KW - Retina/diagnostic imaging

KW - Multiple Sclerosis, Chronic Progressive/diagnostic imaging

KW - Magnetic Resonance Imaging/methods

KW - Prognosis

KW - Nerve Fibers/pathology

KW - Retinal Ganglion Cells/pathology

U2 - 10.1038/s41467-024-49309-7

DO - 10.1038/s41467-024-49309-7

M3 - SCORING: Journal article

C2 - 38897994

VL - 15

SP - 5243

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -