Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes
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Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes. / Esser, Claudia; Bachmann, Anna; Kuhn, Daniela; Schuldt, Kathrin; Förster, Birgit; Thiel, Meike; May, Jürgen; Nolte, Friedrich; Yáñez-Mó, María; Sánchez-Madrid, Francisco; Schinkel, Alfred H; Jalkanen, Sirpa; Craig, Alister G; Bruchhaus, Iris; Horstmann, Rolf D.
In: CELL MICROBIOL, Vol. 16, No. 5, 01.05.2014, p. 701-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes
AU - Esser, Claudia
AU - Bachmann, Anna
AU - Kuhn, Daniela
AU - Schuldt, Kathrin
AU - Förster, Birgit
AU - Thiel, Meike
AU - May, Jürgen
AU - Nolte, Friedrich
AU - Yáñez-Mó, María
AU - Sánchez-Madrid, Francisco
AU - Schinkel, Alfred H
AU - Jalkanen, Sirpa
AU - Craig, Alister G
AU - Bruchhaus, Iris
AU - Horstmann, Rolf D
N1 - © 2014 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.
PY - 2014/5/1
Y1 - 2014/5/1
N2 - The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties.
AB - The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties.
U2 - 10.1111/cmi.12270
DO - 10.1111/cmi.12270
M3 - SCORING: Journal article
C2 - 24444337
VL - 16
SP - 701
EP - 708
JO - CELL MICROBIOL
JF - CELL MICROBIOL
SN - 1462-5814
IS - 5
ER -