Evidence for distinct populations of human Merkel cells.
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Evidence for distinct populations of human Merkel cells. / Eispert, A-C; Fuchs, Franca; Brandner, Johanna; Houdek, Pia; Wladykowski, Ewa; Moll, Ingrid.
In: HISTOCHEM CELL BIOL, Vol. 132, No. 1, 1, 2009, p. 83-93.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Evidence for distinct populations of human Merkel cells.
AU - Eispert, A-C
AU - Fuchs, Franca
AU - Brandner, Johanna
AU - Houdek, Pia
AU - Wladykowski, Ewa
AU - Moll, Ingrid
PY - 2009
Y1 - 2009
N2 - Merkel cells (MCs) are neuroendocrine cells of unknown origin located in the skin. They are identified at electron microscopic level by electron dense granules, at light microscopic level by the presence of cytokeratins 8, 18, 19 and 20. Contradictory reports concerning the presence of other molecules of epithelial as well as neural origin prompted us to investigate whether there are distinct populations of human MCs. Here, we show the heterogeneous expression of villin, N-CAM, NGF-R, and neurofilaments in MCs. Synaptophysin is found in all MCs but with different intensity, nestin is absent. Expression patterns vary between interfollicular epidermis, hair follicles and glabrous epidermis. We conclude that there are distinct populations of MCs, but all populations contain markers for epithelial as well as neural cells. Putative functions of the distinct populations are discussed.
AB - Merkel cells (MCs) are neuroendocrine cells of unknown origin located in the skin. They are identified at electron microscopic level by electron dense granules, at light microscopic level by the presence of cytokeratins 8, 18, 19 and 20. Contradictory reports concerning the presence of other molecules of epithelial as well as neural origin prompted us to investigate whether there are distinct populations of human MCs. Here, we show the heterogeneous expression of villin, N-CAM, NGF-R, and neurofilaments in MCs. Synaptophysin is found in all MCs but with different intensity, nestin is absent. Expression patterns vary between interfollicular epidermis, hair follicles and glabrous epidermis. We conclude that there are distinct populations of MCs, but all populations contain markers for epithelial as well as neural cells. Putative functions of the distinct populations are discussed.
M3 - SCORING: Zeitschriftenaufsatz
VL - 132
SP - 83
EP - 93
JO - HISTOCHEM CELL BIOL
JF - HISTOCHEM CELL BIOL
SN - 0948-6143
IS - 1
M1 - 1
ER -
