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Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads

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Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads. / Lu, Yongtao; Zhu, Yifan; Krause, Matthias; Huber, Gerd; Li, Junyan.

In: MED ENG PHYS, Vol. 69, 07.2019, p. 43-49.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lu, Y, Zhu, Y, Krause, M, Huber, G & Li, J 2019, 'Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads', MED ENG PHYS, vol. 69, pp. 43-49. https://doi.org/10.1016/j.medengphy.2019.05.007

APA

Lu, Y., Zhu, Y., Krause, M., Huber, G., & Li, J. (2019). Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads. MED ENG PHYS, 69, 43-49. https://doi.org/10.1016/j.medengphy.2019.05.007

Vancouver

Lu Y, Zhu Y, Krause M, Huber G, Li J. Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads. MED ENG PHYS. 2019 Jul;69:43-49. https://doi.org/10.1016/j.medengphy.2019.05.007

Bibtex

@article{720ce20b14ee46179d6ed60608e695de,
title = "Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads",
abstract = "Prediction of the vertebral failure load is of great importance for the prevention and early treatment of bone fracture. However, an efficient and effective method for accurately predicting the failure load of vertebral bones is still lacking. The aim of the present study was to evaluate the capability of the simulated dual energy X-ray absorptiometry (DXA)-based finite element (FE) model for predicting vertebral failure loads. Thirteen dissected spinal segments (T11/T12/L1) were scanned using a HR-pQCT scanner and then were mechanically tested until failure. The subject-specific three-dimensional (3D) and two-dimensional (2D) FE models of T12 were generated from the HR-pQCT scanner and the simulated DXA images, respectively. Additionally, the areal bone mineral density (aBMD) and areal bone mineral content (aBMC) of T12 were calculated. The failure loads predicted by the simulated DXA-based 2D FE models were more moderately correlated with the experimental failure loads (R2 = 0.66) than the aBMC (R2 = 0.61) and aBMD (R2 = 0.56). The 2D FE models were slightly outperformed by the HR-pQCT-based 3D FE models (R2 = 0.71). The present study demonstrated that the simulated DXA-based 2D FE model has better capability for predicting the vertebral failure loads than the densitometric measurements but is outperformed by the 3D FE model. The 2D FE model is more suitable for clinical use due to the low radiation dose and low cost, but it remains to be validated by further in vitro and in vivo studies.",
author = "Yongtao Lu and Yifan Zhu and Matthias Krause and Gerd Huber and Junyan Li",
note = "Copyright {\textcopyright} 2019. Published by Elsevier Ltd.",
year = "2019",
month = jul,
doi = "10.1016/j.medengphy.2019.05.007",
language = "English",
volume = "69",
pages = "43--49",
journal = "MED ENG PHYS",
issn = "1350-4533",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Evaluation of the capability of the simulated dual energy X-ray absorptiometry-based two-dimensional finite element models for predicting vertebral failure loads

AU - Lu, Yongtao

AU - Zhu, Yifan

AU - Krause, Matthias

AU - Huber, Gerd

AU - Li, Junyan

N1 - Copyright © 2019. Published by Elsevier Ltd.

PY - 2019/7

Y1 - 2019/7

N2 - Prediction of the vertebral failure load is of great importance for the prevention and early treatment of bone fracture. However, an efficient and effective method for accurately predicting the failure load of vertebral bones is still lacking. The aim of the present study was to evaluate the capability of the simulated dual energy X-ray absorptiometry (DXA)-based finite element (FE) model for predicting vertebral failure loads. Thirteen dissected spinal segments (T11/T12/L1) were scanned using a HR-pQCT scanner and then were mechanically tested until failure. The subject-specific three-dimensional (3D) and two-dimensional (2D) FE models of T12 were generated from the HR-pQCT scanner and the simulated DXA images, respectively. Additionally, the areal bone mineral density (aBMD) and areal bone mineral content (aBMC) of T12 were calculated. The failure loads predicted by the simulated DXA-based 2D FE models were more moderately correlated with the experimental failure loads (R2 = 0.66) than the aBMC (R2 = 0.61) and aBMD (R2 = 0.56). The 2D FE models were slightly outperformed by the HR-pQCT-based 3D FE models (R2 = 0.71). The present study demonstrated that the simulated DXA-based 2D FE model has better capability for predicting the vertebral failure loads than the densitometric measurements but is outperformed by the 3D FE model. The 2D FE model is more suitable for clinical use due to the low radiation dose and low cost, but it remains to be validated by further in vitro and in vivo studies.

AB - Prediction of the vertebral failure load is of great importance for the prevention and early treatment of bone fracture. However, an efficient and effective method for accurately predicting the failure load of vertebral bones is still lacking. The aim of the present study was to evaluate the capability of the simulated dual energy X-ray absorptiometry (DXA)-based finite element (FE) model for predicting vertebral failure loads. Thirteen dissected spinal segments (T11/T12/L1) were scanned using a HR-pQCT scanner and then were mechanically tested until failure. The subject-specific three-dimensional (3D) and two-dimensional (2D) FE models of T12 were generated from the HR-pQCT scanner and the simulated DXA images, respectively. Additionally, the areal bone mineral density (aBMD) and areal bone mineral content (aBMC) of T12 were calculated. The failure loads predicted by the simulated DXA-based 2D FE models were more moderately correlated with the experimental failure loads (R2 = 0.66) than the aBMC (R2 = 0.61) and aBMD (R2 = 0.56). The 2D FE models were slightly outperformed by the HR-pQCT-based 3D FE models (R2 = 0.71). The present study demonstrated that the simulated DXA-based 2D FE model has better capability for predicting the vertebral failure loads than the densitometric measurements but is outperformed by the 3D FE model. The 2D FE model is more suitable for clinical use due to the low radiation dose and low cost, but it remains to be validated by further in vitro and in vivo studies.

U2 - 10.1016/j.medengphy.2019.05.007

DO - 10.1016/j.medengphy.2019.05.007

M3 - SCORING: Journal article

C2 - 31147202

VL - 69

SP - 43

EP - 49

JO - MED ENG PHYS

JF - MED ENG PHYS

SN - 1350-4533

ER -