Evaluation of six different types of sequential conditioning regimens for allogeneic stem cell transplantation in relapsed/refractory acute myelogenous leukemia - a study of the Acute Leukemia Working Party of the EBMT
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Evaluation of six different types of sequential conditioning regimens for allogeneic stem cell transplantation in relapsed/refractory acute myelogenous leukemia - a study of the Acute Leukemia Working Party of the EBMT. / Heinicke, Thomas; Labopin, Myriam; Polge, Emmanuelle; Stelljes, Matthias; Ganser, Arnold; Tischer, Johanna; Brecht, Arne; Kröger, Nicolaus; Beelen, Dietrich W; Scheid, Christof; Bethge, Wolfgang; Dreger, Peter; Bunjes, Donald; Wagner, Eva; Platzbecker, Uwe; Savani, Bipin N; Nagler, Arnon; Mohty, Mohamad.
In: LEUKEMIA LYMPHOMA, Vol. 62, No. 2, 02.2021, p. 399-409.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Evaluation of six different types of sequential conditioning regimens for allogeneic stem cell transplantation in relapsed/refractory acute myelogenous leukemia - a study of the Acute Leukemia Working Party of the EBMT
AU - Heinicke, Thomas
AU - Labopin, Myriam
AU - Polge, Emmanuelle
AU - Stelljes, Matthias
AU - Ganser, Arnold
AU - Tischer, Johanna
AU - Brecht, Arne
AU - Kröger, Nicolaus
AU - Beelen, Dietrich W
AU - Scheid, Christof
AU - Bethge, Wolfgang
AU - Dreger, Peter
AU - Bunjes, Donald
AU - Wagner, Eva
AU - Platzbecker, Uwe
AU - Savani, Bipin N
AU - Nagler, Arnon
AU - Mohty, Mohamad
PY - 2021/2
Y1 - 2021/2
N2 - The Acute Leukemia Working Party (ALWP) of the EBMT assessed the outcome of allogeneic stem cell transplantation (alloSCT) in patients with relapsed/refractory AML (r/rAML) evaluating six sequential conditioning regimens (SR) groups. A total of 2132 patients were included. LFS at 2 years was 28.9%, 33.6%, 35.3%, 20.6%, 24.4%, and 27% for the FLAMSA-TBI4, FLAMSA-Chemo, Mel-Flu-TBI8, Mel-Treo-Flu, Thio-ETO-Cy-Bu2-Flu, and Clo-ARAC-(Bu2/TBI4)-Cy groups, respectively. In patients <55 years of age Mel-Flu-TBI8 had the best LFS, which was statistically significant only in comparison to the Mel-Treo-Flu group, while in patients ≥55 years LFS was best with FLAMSA-Chemo without significant differences compared to FLAMSA-TBI4 and Mel-Flu-TBI8. Furthermore, best NRM rates were obtained with the two FLAMSA regimens groups. Our study suggests that in younger (<55 years) patients a more intense regimen might be used whereas in older (≥55 years) patients the focus might be more on tolerability.
AB - The Acute Leukemia Working Party (ALWP) of the EBMT assessed the outcome of allogeneic stem cell transplantation (alloSCT) in patients with relapsed/refractory AML (r/rAML) evaluating six sequential conditioning regimens (SR) groups. A total of 2132 patients were included. LFS at 2 years was 28.9%, 33.6%, 35.3%, 20.6%, 24.4%, and 27% for the FLAMSA-TBI4, FLAMSA-Chemo, Mel-Flu-TBI8, Mel-Treo-Flu, Thio-ETO-Cy-Bu2-Flu, and Clo-ARAC-(Bu2/TBI4)-Cy groups, respectively. In patients <55 years of age Mel-Flu-TBI8 had the best LFS, which was statistically significant only in comparison to the Mel-Treo-Flu group, while in patients ≥55 years LFS was best with FLAMSA-Chemo without significant differences compared to FLAMSA-TBI4 and Mel-Flu-TBI8. Furthermore, best NRM rates were obtained with the two FLAMSA regimens groups. Our study suggests that in younger (<55 years) patients a more intense regimen might be used whereas in older (≥55 years) patients the focus might be more on tolerability.
U2 - 10.1080/10428194.2020.1827248
DO - 10.1080/10428194.2020.1827248
M3 - SCORING: Journal article
C2 - 33040622
VL - 62
SP - 399
EP - 409
JO - LEUKEMIA LYMPHOMA
JF - LEUKEMIA LYMPHOMA
SN - 1042-8194
IS - 2
ER -
