Evaluation of procalcitonin for predicting septic multiorgan failure and overall prognosis in secondary peritonitis: a prospective, international multicenter study.
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Evaluation of procalcitonin for predicting septic multiorgan failure and overall prognosis in secondary peritonitis: a prospective, international multicenter study. / Rau, Bettina M; Frigerio, Isabella; Büchler, Markus W; Wegscheider, Karl; Bassi, Claudio; Puolakkainen, Pauli A; Beger, Hans G; Schilling, Martin K.
In: ARCH SURG-CHICAGO, Vol. 142, No. 2, 2, 2007, p. 134-142.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Evaluation of procalcitonin for predicting septic multiorgan failure and overall prognosis in secondary peritonitis: a prospective, international multicenter study.
AU - Rau, Bettina M
AU - Frigerio, Isabella
AU - Büchler, Markus W
AU - Wegscheider, Karl
AU - Bassi, Claudio
AU - Puolakkainen, Pauli A
AU - Beger, Hans G
AU - Schilling, Martin K
PY - 2007
Y1 - 2007
N2 - HYPOTHESIS: Infections and sepsis are major complications in secondary peritonitis and still represent a diagnostic challenge. We hypothesized that the laboratory marker procalcitonin would provide an early and reliable assessment of septic complications. DESIGN: Prospective, international, multicenter inception cohort study. SETTING: Five European surgical referral centers. PATIENTS: Eighty-two patients with intraoperatively proven secondary peritonitis were enrolled within 96 hours of symptom onset. MAIN OUTCOME MEASURES: Procalcitonin and the laboratory routine marker C-reactive protein (CRP) were prospectively assessed and monitored for a maximum of 21 consecutive days. RESULTS: Procalcitonin concentrations were most closely correlated with the development of septic multiorgan dysfunction syndrome (MODS), with peak levels occurring early after symptom onset or during the immediate postoperative course. No such correlation was observed for CRP. According to receiver operating characteristic analysis, a procalcitonin value of 10.0 ng/mL or greater on 2 consecutive days was superior to a CRP level of 210 mg/L or greater for predicting septic MODS, with sensitivity, specificity, and positive and negative predictive values of 65%, 92%, 83%, and 81% for procalcitonin and 67%, 58%, 49%, and 74% for CRP, respectively (P
AB - HYPOTHESIS: Infections and sepsis are major complications in secondary peritonitis and still represent a diagnostic challenge. We hypothesized that the laboratory marker procalcitonin would provide an early and reliable assessment of septic complications. DESIGN: Prospective, international, multicenter inception cohort study. SETTING: Five European surgical referral centers. PATIENTS: Eighty-two patients with intraoperatively proven secondary peritonitis were enrolled within 96 hours of symptom onset. MAIN OUTCOME MEASURES: Procalcitonin and the laboratory routine marker C-reactive protein (CRP) were prospectively assessed and monitored for a maximum of 21 consecutive days. RESULTS: Procalcitonin concentrations were most closely correlated with the development of septic multiorgan dysfunction syndrome (MODS), with peak levels occurring early after symptom onset or during the immediate postoperative course. No such correlation was observed for CRP. According to receiver operating characteristic analysis, a procalcitonin value of 10.0 ng/mL or greater on 2 consecutive days was superior to a CRP level of 210 mg/L or greater for predicting septic MODS, with sensitivity, specificity, and positive and negative predictive values of 65%, 92%, 83%, and 81% for procalcitonin and 67%, 58%, 49%, and 74% for CRP, respectively (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 142
SP - 134
EP - 142
IS - 2
M1 - 2
ER -
