Evaluation of Periodontal Space Widening in Patients with Antiresorptive Drug-related Osteonecrosis of the Jaws (ARONJ) on Panoramic Radiographs
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Evaluation of Periodontal Space Widening in Patients with Antiresorptive Drug-related Osteonecrosis of the Jaws (ARONJ) on Panoramic Radiographs. / Assaf, Alexandre T; Amberg, Vivien; Smeets, Ralf; Wikner, Johannes; Hanken, Henning; Semmusch, Jan; Ewald, Florian; Rashad, Ashkan; Friedrich, Reinhard E.
In: ANTICANCER RES, Vol. 38, No. 9, 09.2018, p. 5305-5314.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
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TY - JOUR
T1 - Evaluation of Periodontal Space Widening in Patients with Antiresorptive Drug-related Osteonecrosis of the Jaws (ARONJ) on Panoramic Radiographs
AU - Assaf, Alexandre T
AU - Amberg, Vivien
AU - Smeets, Ralf
AU - Wikner, Johannes
AU - Hanken, Henning
AU - Semmusch, Jan
AU - Ewald, Florian
AU - Rashad, Ashkan
AU - Friedrich, Reinhard E
N1 - Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2018/9
Y1 - 2018/9
N2 - BACKGROUND/AIM: The purpose of this study was to evaluate a potential widening of the periodontal space as an initial measurable imaging criterium on panoramic radiographs in patients with the diagnosis of antiresorptive drug related osteonecrosis of the jaw (ARONJ).PATIENTS AND METHODS: A retrospective analysis of panoramic radiographs of 16 patients (12 females and 4 males; mean age is 70.5 years, standard deviation is 14 years) was performed, over a period of 12 months with the diagnosis of ARONJ. Panoramic radiographs of 16 healthy patients (12 females and 4 males; mean age was 70.6 years, standard deviation was 13.8 years) without diagnosis of ARONJ served as controls. All images were taken with the same device and were evaluated by two experienced maxillofacial surgeons and one dentist.RESULTS: Compared to the control group, a mean widening of the periodontal space of 0.06 mm (confidence interval (CI)=0.05-0.17 mm) was found in the study group. However, this difference was not statistically significant.CONCLUSION: Although a very extensive and sophisticated interindividual comparison was performed to evaluate for slight changes of the periodontal space in patients with antiresorptive drug therapy, our results demonstrate that PDS widening is not a predictive parameter for ARONJ. Therefore, our results indicate that panoramic radiographs are not sufficient enough to allow assessment of stages and disease progress in ARONJ patients regarding to periodontal space widening.
AB - BACKGROUND/AIM: The purpose of this study was to evaluate a potential widening of the periodontal space as an initial measurable imaging criterium on panoramic radiographs in patients with the diagnosis of antiresorptive drug related osteonecrosis of the jaw (ARONJ).PATIENTS AND METHODS: A retrospective analysis of panoramic radiographs of 16 patients (12 females and 4 males; mean age is 70.5 years, standard deviation is 14 years) was performed, over a period of 12 months with the diagnosis of ARONJ. Panoramic radiographs of 16 healthy patients (12 females and 4 males; mean age was 70.6 years, standard deviation was 13.8 years) without diagnosis of ARONJ served as controls. All images were taken with the same device and were evaluated by two experienced maxillofacial surgeons and one dentist.RESULTS: Compared to the control group, a mean widening of the periodontal space of 0.06 mm (confidence interval (CI)=0.05-0.17 mm) was found in the study group. However, this difference was not statistically significant.CONCLUSION: Although a very extensive and sophisticated interindividual comparison was performed to evaluate for slight changes of the periodontal space in patients with antiresorptive drug therapy, our results demonstrate that PDS widening is not a predictive parameter for ARONJ. Therefore, our results indicate that panoramic radiographs are not sufficient enough to allow assessment of stages and disease progress in ARONJ patients regarding to periodontal space widening.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Alveolar Process
KW - Bisphosphonate-Associated Osteonecrosis of the Jaw
KW - Bone Density Conservation Agents
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Observer Variation
KW - Predictive Value of Tests
KW - Radiography, Panoramic
KW - Reproducibility of Results
KW - Retrospective Studies
KW - Severity of Illness Index
KW - Journal Article
U2 - 10.21873/anticanres.12857
DO - 10.21873/anticanres.12857
M3 - SCORING: Journal article
C2 - 30194182
VL - 38
SP - 5305
EP - 5314
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 9
ER -
