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Evaluation of microribonucleic acids as potential biomarkers in the bicuspid aortic valve-associated aortopathy

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Evaluation of microribonucleic acids as potential biomarkers in the bicuspid aortic valve-associated aortopathy. / Girdauskas, Evaldas; Petersen, Johannes; Neumann, Niklas; Groß, Tatiana; Naito, Shiho; Hillebrand, Mathias; Reichenspurner, Hermann; Blankenberg, Stefan; Zeller, Tanja.

In: INTERACT CARDIOV TH, Vol. 27, No. 1, 01.07.2018, p. 60-66.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Girdauskas, E, Petersen, J, Neumann, N, Groß, T, Naito, S, Hillebrand, M, Reichenspurner, H, Blankenberg, S & Zeller, T 2018, 'Evaluation of microribonucleic acids as potential biomarkers in the bicuspid aortic valve-associated aortopathy', INTERACT CARDIOV TH, vol. 27, no. 1, pp. 60-66. https://doi.org/10.1093/icvts/ivy033

APA

Girdauskas, E., Petersen, J., Neumann, N., Groß, T., Naito, S., Hillebrand, M., Reichenspurner, H., Blankenberg, S., & Zeller, T. (2018). Evaluation of microribonucleic acids as potential biomarkers in the bicuspid aortic valve-associated aortopathy. INTERACT CARDIOV TH, 27(1), 60-66. https://doi.org/10.1093/icvts/ivy033

Vancouver

Girdauskas E, Petersen J, Neumann N, Groß T, Naito S, Hillebrand M et al. Evaluation of microribonucleic acids as potential biomarkers in the bicuspid aortic valve-associated aortopathy. INTERACT CARDIOV TH. 2018 Jul 1;27(1):60-66. https://doi.org/10.1093/icvts/ivy033

Bibtex

@article{1d12d6aeada2490e8298808634f0161d,
title = "Evaluation of microribonucleic acids as potential biomarkers in the bicuspid aortic valve-associated aortopathy",
abstract = "OBJECTIVES: We aimed to evaluate the impact of microRNAs to predict the bicuspid aortic valve (BAV)-associated aortopathy.METHODS: Sixty-three BAV patients (mean age 47 ± 11 years, 92% men) with root dilatation, who underwent aortic valve ± proximal aortic surgery (mean post-AVR follow-up 10.3 ± 6.9 years) were included. The BAV aortopathy entities were categorized in the 'less dilated' (aortic root <50 mm) and 'severely dilated' (aortic root ≥50 mm) aorta. Several microRNAs were assessed using polymerase chain reaction. End-points were the correlation between microRNAs and severity of aortopathy/prevalence of adverse aortic events.RESULTS: Circulating levels of miR-17 and miR-106a were strongly correlated (r = 0.84, P < 0.001). Our analysis yielded significantly higher values of miR-17 (delta Ct 2.09 ± 0.64 vs delta Ct 1.68 ± 0.64, P = 0.02) and miR-106a (delta Ct 5.88 ± 0.43 vs delta Ct 5.61 ± 0.60, P = 0.046) in BAV patients with the less dilated versus the severely dilated aorta. miR-17 (delta Ct 1.51 ± 0.73 vs delta Ct 2.00 ± 0.61, P = 0.02) and miR-106a (delta Ct 5.39 ± 0.69 vs delta Ct 5.85 ± 0.44, P = 0.007) were significantly downregulated in BAV patients who experienced adverse aortic events.CONCLUSIONS: Expression of circulating miR-17 and miR-106a in the BAV root phenotype patients correlates with the severity of aortopathy and the risk of adverse aortic events. MicroRNAs have the potential to serve as biomarkers in the BAV-associated aortopathy.",
keywords = "Adult, Aged, Aortic Diseases/blood, Aortic Valve/abnormalities, Bicuspid Aortic Valve Disease, Biomarkers/blood, Case-Control Studies, Dilatation, Pathologic, Female, Heart Valve Diseases/blood, Humans, Male, MicroRNAs/blood, Middle Aged, Phenotype, Retrospective Studies",
author = "Evaldas Girdauskas and Johannes Petersen and Niklas Neumann and Tatiana Gro{\ss} and Shiho Naito and Mathias Hillebrand and Hermann Reichenspurner and Stefan Blankenberg and Tanja Zeller",
year = "2018",
month = jul,
day = "1",
doi = "10.1093/icvts/ivy033",
language = "English",
volume = "27",
pages = "60--66",
journal = "INTERACT CARDIOV TH",
issn = "1569-9293",
publisher = "European Association for Cardio-Thoracic Surgery",
number = "1",

}

RIS

TY - JOUR

T1 - Evaluation of microribonucleic acids as potential biomarkers in the bicuspid aortic valve-associated aortopathy

AU - Girdauskas, Evaldas

AU - Petersen, Johannes

AU - Neumann, Niklas

AU - Groß, Tatiana

AU - Naito, Shiho

AU - Hillebrand, Mathias

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Zeller, Tanja

PY - 2018/7/1

Y1 - 2018/7/1

N2 - OBJECTIVES: We aimed to evaluate the impact of microRNAs to predict the bicuspid aortic valve (BAV)-associated aortopathy.METHODS: Sixty-three BAV patients (mean age 47 ± 11 years, 92% men) with root dilatation, who underwent aortic valve ± proximal aortic surgery (mean post-AVR follow-up 10.3 ± 6.9 years) were included. The BAV aortopathy entities were categorized in the 'less dilated' (aortic root <50 mm) and 'severely dilated' (aortic root ≥50 mm) aorta. Several microRNAs were assessed using polymerase chain reaction. End-points were the correlation between microRNAs and severity of aortopathy/prevalence of adverse aortic events.RESULTS: Circulating levels of miR-17 and miR-106a were strongly correlated (r = 0.84, P < 0.001). Our analysis yielded significantly higher values of miR-17 (delta Ct 2.09 ± 0.64 vs delta Ct 1.68 ± 0.64, P = 0.02) and miR-106a (delta Ct 5.88 ± 0.43 vs delta Ct 5.61 ± 0.60, P = 0.046) in BAV patients with the less dilated versus the severely dilated aorta. miR-17 (delta Ct 1.51 ± 0.73 vs delta Ct 2.00 ± 0.61, P = 0.02) and miR-106a (delta Ct 5.39 ± 0.69 vs delta Ct 5.85 ± 0.44, P = 0.007) were significantly downregulated in BAV patients who experienced adverse aortic events.CONCLUSIONS: Expression of circulating miR-17 and miR-106a in the BAV root phenotype patients correlates with the severity of aortopathy and the risk of adverse aortic events. MicroRNAs have the potential to serve as biomarkers in the BAV-associated aortopathy.

AB - OBJECTIVES: We aimed to evaluate the impact of microRNAs to predict the bicuspid aortic valve (BAV)-associated aortopathy.METHODS: Sixty-three BAV patients (mean age 47 ± 11 years, 92% men) with root dilatation, who underwent aortic valve ± proximal aortic surgery (mean post-AVR follow-up 10.3 ± 6.9 years) were included. The BAV aortopathy entities were categorized in the 'less dilated' (aortic root <50 mm) and 'severely dilated' (aortic root ≥50 mm) aorta. Several microRNAs were assessed using polymerase chain reaction. End-points were the correlation between microRNAs and severity of aortopathy/prevalence of adverse aortic events.RESULTS: Circulating levels of miR-17 and miR-106a were strongly correlated (r = 0.84, P < 0.001). Our analysis yielded significantly higher values of miR-17 (delta Ct 2.09 ± 0.64 vs delta Ct 1.68 ± 0.64, P = 0.02) and miR-106a (delta Ct 5.88 ± 0.43 vs delta Ct 5.61 ± 0.60, P = 0.046) in BAV patients with the less dilated versus the severely dilated aorta. miR-17 (delta Ct 1.51 ± 0.73 vs delta Ct 2.00 ± 0.61, P = 0.02) and miR-106a (delta Ct 5.39 ± 0.69 vs delta Ct 5.85 ± 0.44, P = 0.007) were significantly downregulated in BAV patients who experienced adverse aortic events.CONCLUSIONS: Expression of circulating miR-17 and miR-106a in the BAV root phenotype patients correlates with the severity of aortopathy and the risk of adverse aortic events. MicroRNAs have the potential to serve as biomarkers in the BAV-associated aortopathy.

KW - Adult

KW - Aged

KW - Aortic Diseases/blood

KW - Aortic Valve/abnormalities

KW - Bicuspid Aortic Valve Disease

KW - Biomarkers/blood

KW - Case-Control Studies

KW - Dilatation, Pathologic

KW - Female

KW - Heart Valve Diseases/blood

KW - Humans

KW - Male

KW - MicroRNAs/blood

KW - Middle Aged

KW - Phenotype

KW - Retrospective Studies

U2 - 10.1093/icvts/ivy033

DO - 10.1093/icvts/ivy033

M3 - SCORING: Journal article

C2 - 29462317

VL - 27

SP - 60

EP - 66

JO - INTERACT CARDIOV TH

JF - INTERACT CARDIOV TH

SN - 1569-9293

IS - 1

ER -