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Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1

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Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1. / Salamon, Johannes; Derlin, Thorsten; Bannas, Peter; Busch, Jasmin D; Herrmann, Jochen; Bockhorn, Maximilian; Hagel, Christian; Friedrich, Reinhard E; Adam, Gerhard; Mautner, Victor-Felix.

In: EUR J NUCL MED MOL I, Vol. 40, No. 5, 01.05.2013, p. 685-92.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Salamon, J, Derlin, T, Bannas, P, Busch, JD, Herrmann, J, Bockhorn, M, Hagel, C, Friedrich, RE, Adam, G & Mautner, V-F 2013, 'Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1', EUR J NUCL MED MOL I, vol. 40, no. 5, pp. 685-92. https://doi.org/10.1007/s00259-012-2314-6

APA

Salamon, J., Derlin, T., Bannas, P., Busch, J. D., Herrmann, J., Bockhorn, M., Hagel, C., Friedrich, R. E., Adam, G., & Mautner, V-F. (2013). Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1. EUR J NUCL MED MOL I, 40(5), 685-92. https://doi.org/10.1007/s00259-012-2314-6

Vancouver

Salamon J, Derlin T, Bannas P, Busch JD, Herrmann J, Bockhorn M et al. Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1. EUR J NUCL MED MOL I. 2013 May 1;40(5):685-92. https://doi.org/10.1007/s00259-012-2314-6

Bibtex

@article{8c4164f222424d749ea7b4538a14039c,
title = "Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1",
abstract = "PURPOSE: The aim of the study was to evaluate the potential usefulness of intratumoural tracer uptake heterogeneity on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT as compared to a cut-off maximum standardized uptake value (SUVmax) for characterization of peripheral nerve sheath tumours (PNSTs) in neurofibromatosis type 1 (NF1).METHODS: Fifty patients suffering from NF1 were examined by (18)F-FDG PET/CT. Intralesional tracer uptake was analysed qualitatively and semi-quantitatively by measuring the mean and maximum SUV. Uptake heterogeneity was graded qualitatively using a three-point scale and semi-quantitatively by calculating an SUV-based heterogeneity index (HISUV). Cohen's κ was used to determine inter- and intra-rater agreement. Histopathological evaluation and clinical as well as radiological follow-up examinations served as the reference standards.RESULTS: A highly significant correlation between the degree of intratumoural uptake heterogeneity on (18)F-FDG PET and malignant transformation of PNSTs was observed (p < 0.0001). Semi-quantitative HISUV was significantly higher in malignant PNSTs (MPNSTs) than in benign tumours (p = 0.0002). Both intralesional heterogeneity and SUVmax could be used to identify malignant tumours with a sensitivity of 100 %. Cohen's κ was 0.86 for inter-rater agreement and 0.88 for intra-rater agreement on heterogeneity.CONCLUSION: MPNSTs in patients with NF1 demonstrate considerable intratumoural uptake heterogeneity on (18)F-FDG PET/CT. Assessment of tumour heterogeneity is highly reproducible. Both tumour heterogeneity and a cut-off SUVmax may be used to sensitively identify malignant PNSTs, but the specificity is higher for the latter. A combination of both methods leads to a non-significant improvement in diagnostic performance.",
keywords = "Adolescent, Adult, Aged, Biological Transport, Child, Child, Preschool, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Multimodal Imaging, Nerve Sheath Neoplasms, Neurofibromatosis 1, Positron-Emission Tomography, Reproducibility of Results, Retrospective Studies, Tomography, X-Ray Computed, Young Adult",
author = "Johannes Salamon and Thorsten Derlin and Peter Bannas and Busch, {Jasmin D} and Jochen Herrmann and Maximilian Bockhorn and Christian Hagel and Friedrich, {Reinhard E} and Gerhard Adam and Victor-Felix Mautner",
year = "2013",
month = may,
day = "1",
doi = "10.1007/s00259-012-2314-6",
language = "English",
volume = "40",
pages = "685--92",
journal = "EUR J NUCL MED MOL I",
issn = "1619-7070",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1

AU - Salamon, Johannes

AU - Derlin, Thorsten

AU - Bannas, Peter

AU - Busch, Jasmin D

AU - Herrmann, Jochen

AU - Bockhorn, Maximilian

AU - Hagel, Christian

AU - Friedrich, Reinhard E

AU - Adam, Gerhard

AU - Mautner, Victor-Felix

PY - 2013/5/1

Y1 - 2013/5/1

N2 - PURPOSE: The aim of the study was to evaluate the potential usefulness of intratumoural tracer uptake heterogeneity on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT as compared to a cut-off maximum standardized uptake value (SUVmax) for characterization of peripheral nerve sheath tumours (PNSTs) in neurofibromatosis type 1 (NF1).METHODS: Fifty patients suffering from NF1 were examined by (18)F-FDG PET/CT. Intralesional tracer uptake was analysed qualitatively and semi-quantitatively by measuring the mean and maximum SUV. Uptake heterogeneity was graded qualitatively using a three-point scale and semi-quantitatively by calculating an SUV-based heterogeneity index (HISUV). Cohen's κ was used to determine inter- and intra-rater agreement. Histopathological evaluation and clinical as well as radiological follow-up examinations served as the reference standards.RESULTS: A highly significant correlation between the degree of intratumoural uptake heterogeneity on (18)F-FDG PET and malignant transformation of PNSTs was observed (p < 0.0001). Semi-quantitative HISUV was significantly higher in malignant PNSTs (MPNSTs) than in benign tumours (p = 0.0002). Both intralesional heterogeneity and SUVmax could be used to identify malignant tumours with a sensitivity of 100 %. Cohen's κ was 0.86 for inter-rater agreement and 0.88 for intra-rater agreement on heterogeneity.CONCLUSION: MPNSTs in patients with NF1 demonstrate considerable intratumoural uptake heterogeneity on (18)F-FDG PET/CT. Assessment of tumour heterogeneity is highly reproducible. Both tumour heterogeneity and a cut-off SUVmax may be used to sensitively identify malignant PNSTs, but the specificity is higher for the latter. A combination of both methods leads to a non-significant improvement in diagnostic performance.

AB - PURPOSE: The aim of the study was to evaluate the potential usefulness of intratumoural tracer uptake heterogeneity on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT as compared to a cut-off maximum standardized uptake value (SUVmax) for characterization of peripheral nerve sheath tumours (PNSTs) in neurofibromatosis type 1 (NF1).METHODS: Fifty patients suffering from NF1 were examined by (18)F-FDG PET/CT. Intralesional tracer uptake was analysed qualitatively and semi-quantitatively by measuring the mean and maximum SUV. Uptake heterogeneity was graded qualitatively using a three-point scale and semi-quantitatively by calculating an SUV-based heterogeneity index (HISUV). Cohen's κ was used to determine inter- and intra-rater agreement. Histopathological evaluation and clinical as well as radiological follow-up examinations served as the reference standards.RESULTS: A highly significant correlation between the degree of intratumoural uptake heterogeneity on (18)F-FDG PET and malignant transformation of PNSTs was observed (p < 0.0001). Semi-quantitative HISUV was significantly higher in malignant PNSTs (MPNSTs) than in benign tumours (p = 0.0002). Both intralesional heterogeneity and SUVmax could be used to identify malignant tumours with a sensitivity of 100 %. Cohen's κ was 0.86 for inter-rater agreement and 0.88 for intra-rater agreement on heterogeneity.CONCLUSION: MPNSTs in patients with NF1 demonstrate considerable intratumoural uptake heterogeneity on (18)F-FDG PET/CT. Assessment of tumour heterogeneity is highly reproducible. Both tumour heterogeneity and a cut-off SUVmax may be used to sensitively identify malignant PNSTs, but the specificity is higher for the latter. A combination of both methods leads to a non-significant improvement in diagnostic performance.

KW - Adolescent

KW - Adult

KW - Aged

KW - Biological Transport

KW - Child

KW - Child, Preschool

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Male

KW - Middle Aged

KW - Multimodal Imaging

KW - Nerve Sheath Neoplasms

KW - Neurofibromatosis 1

KW - Positron-Emission Tomography

KW - Reproducibility of Results

KW - Retrospective Studies

KW - Tomography, X-Ray Computed

KW - Young Adult

U2 - 10.1007/s00259-012-2314-6

DO - 10.1007/s00259-012-2314-6

M3 - SCORING: Journal article

C2 - 23232507

VL - 40

SP - 685

EP - 692

JO - EUR J NUCL MED MOL I

JF - EUR J NUCL MED MOL I

SN - 1619-7070

IS - 5

ER -