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Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography

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Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography. / Golatta, Michael; Baggs, Christina; Schweitzer-Martin, Mirjam; Domschke, Christoph; Schott, Sarah; Harcos, Aba; Scharf, Alexander; Junkermann, Hans; Rauch, Geraldine; Rom, Joachim; Sohn, Christof; Heil, Joerg.

In: ARCH GYNECOL OBSTET, Vol. 291, No. 4, 04.2015, p. 889-895.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Golatta, M, Baggs, C, Schweitzer-Martin, M, Domschke, C, Schott, S, Harcos, A, Scharf, A, Junkermann, H, Rauch, G, Rom, J, Sohn, C & Heil, J 2015, 'Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography', ARCH GYNECOL OBSTET, vol. 291, no. 4, pp. 889-895. https://doi.org/10.1007/s00404-014-3509-9

APA

Golatta, M., Baggs, C., Schweitzer-Martin, M., Domschke, C., Schott, S., Harcos, A., Scharf, A., Junkermann, H., Rauch, G., Rom, J., Sohn, C., & Heil, J. (2015). Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography. ARCH GYNECOL OBSTET, 291(4), 889-895. https://doi.org/10.1007/s00404-014-3509-9

Vancouver

Golatta M, Baggs C, Schweitzer-Martin M, Domschke C, Schott S, Harcos A et al. Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography. ARCH GYNECOL OBSTET. 2015 Apr;291(4):889-895. https://doi.org/10.1007/s00404-014-3509-9

Bibtex

@article{a7e2a6225a7f4506ae22a9ac4cc8ea3c,
title = "Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography",
abstract = "PURPOSE: Automated three-dimensional (3D) breast ultrasound (US) systems are meant to overcome the shortcomings of hand-held ultrasound (HHUS). The aim of this study is to analyze and compare clinical performance of an automated 3D-US system by comparing it with HHUS, mammography and the clinical gold standard (defined as the combination of HHUS, mammography and-if indicated-histology).METHODS: Nine hundred and eighty three patients (=1,966 breasts) were enrolled in this monocentric, explorative and prospective cohort study. All examinations were analyzed blinded to the patients´ history and to the results of the routine imaging. The agreement of automated 3D-US with HHUS, mammography and the gold standard was assessed with kappa statistics. Sensitivity, specificity and positive and negative predictive value were calculated to assess the test performance.RESULTS: Blinded to the results of the gold standard the agreement between automated 3D-US and HHUS or mammography was fair, given by a Kappa coefficient of 0.31 (95% CI [0.26;0.36], p < 0.0001) and 0.25 (95% CI [0.2;0.3], p < 0.0001), respectively. Our results showed a high negative predictive value (NPV) of 98%, a high specificity of 85% and a sensitivity of 74% based on the cases with US-guided biopsy. Including the cases where the lesion was seen in a second-look automated 3D-US the sensitivity improved to 84% (NPV = 99%, specificity = 85%).CONCLUSION: The results of this study let us suggest, that automated 3D-US might be a helpful new tool in breast imaging, especially in screening.",
keywords = "Adult, Aged, Breast, Female, Humans, Image Interpretation, Computer-Assisted, Mammography, Middle Aged, Prospective Studies, Sensitivity and Specificity, Ultrasonography, Mammary, Comparative Study, Evaluation Studies, Journal Article",
author = "Michael Golatta and Christina Baggs and Mirjam Schweitzer-Martin and Christoph Domschke and Sarah Schott and Aba Harcos and Alexander Scharf and Hans Junkermann and Geraldine Rauch and Joachim Rom and Christof Sohn and Joerg Heil",
year = "2015",
month = apr,
doi = "10.1007/s00404-014-3509-9",
language = "English",
volume = "291",
pages = "889--895",
journal = "ARCH GYNECOL OBSTET",
issn = "0932-0067",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography

AU - Golatta, Michael

AU - Baggs, Christina

AU - Schweitzer-Martin, Mirjam

AU - Domschke, Christoph

AU - Schott, Sarah

AU - Harcos, Aba

AU - Scharf, Alexander

AU - Junkermann, Hans

AU - Rauch, Geraldine

AU - Rom, Joachim

AU - Sohn, Christof

AU - Heil, Joerg

PY - 2015/4

Y1 - 2015/4

N2 - PURPOSE: Automated three-dimensional (3D) breast ultrasound (US) systems are meant to overcome the shortcomings of hand-held ultrasound (HHUS). The aim of this study is to analyze and compare clinical performance of an automated 3D-US system by comparing it with HHUS, mammography and the clinical gold standard (defined as the combination of HHUS, mammography and-if indicated-histology).METHODS: Nine hundred and eighty three patients (=1,966 breasts) were enrolled in this monocentric, explorative and prospective cohort study. All examinations were analyzed blinded to the patients´ history and to the results of the routine imaging. The agreement of automated 3D-US with HHUS, mammography and the gold standard was assessed with kappa statistics. Sensitivity, specificity and positive and negative predictive value were calculated to assess the test performance.RESULTS: Blinded to the results of the gold standard the agreement between automated 3D-US and HHUS or mammography was fair, given by a Kappa coefficient of 0.31 (95% CI [0.26;0.36], p < 0.0001) and 0.25 (95% CI [0.2;0.3], p < 0.0001), respectively. Our results showed a high negative predictive value (NPV) of 98%, a high specificity of 85% and a sensitivity of 74% based on the cases with US-guided biopsy. Including the cases where the lesion was seen in a second-look automated 3D-US the sensitivity improved to 84% (NPV = 99%, specificity = 85%).CONCLUSION: The results of this study let us suggest, that automated 3D-US might be a helpful new tool in breast imaging, especially in screening.

AB - PURPOSE: Automated three-dimensional (3D) breast ultrasound (US) systems are meant to overcome the shortcomings of hand-held ultrasound (HHUS). The aim of this study is to analyze and compare clinical performance of an automated 3D-US system by comparing it with HHUS, mammography and the clinical gold standard (defined as the combination of HHUS, mammography and-if indicated-histology).METHODS: Nine hundred and eighty three patients (=1,966 breasts) were enrolled in this monocentric, explorative and prospective cohort study. All examinations were analyzed blinded to the patients´ history and to the results of the routine imaging. The agreement of automated 3D-US with HHUS, mammography and the gold standard was assessed with kappa statistics. Sensitivity, specificity and positive and negative predictive value were calculated to assess the test performance.RESULTS: Blinded to the results of the gold standard the agreement between automated 3D-US and HHUS or mammography was fair, given by a Kappa coefficient of 0.31 (95% CI [0.26;0.36], p < 0.0001) and 0.25 (95% CI [0.2;0.3], p < 0.0001), respectively. Our results showed a high negative predictive value (NPV) of 98%, a high specificity of 85% and a sensitivity of 74% based on the cases with US-guided biopsy. Including the cases where the lesion was seen in a second-look automated 3D-US the sensitivity improved to 84% (NPV = 99%, specificity = 85%).CONCLUSION: The results of this study let us suggest, that automated 3D-US might be a helpful new tool in breast imaging, especially in screening.

KW - Adult

KW - Aged

KW - Breast

KW - Female

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Mammography

KW - Middle Aged

KW - Prospective Studies

KW - Sensitivity and Specificity

KW - Ultrasonography, Mammary

KW - Comparative Study

KW - Evaluation Studies

KW - Journal Article

U2 - 10.1007/s00404-014-3509-9

DO - 10.1007/s00404-014-3509-9

M3 - SCORING: Journal article

C2 - 25311201

VL - 291

SP - 889

EP - 895

JO - ARCH GYNECOL OBSTET

JF - ARCH GYNECOL OBSTET

SN - 0932-0067

IS - 4

ER -