European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II.

TY - JOUR

T1 - European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II.

AU - Krege, Susanne

AU - Beyer, Jörg

AU - Souchon, Rainer

AU - Albers, Peter

AU - Albrecht, Walter

AU - Algaba, Ferran

AU - Bamberg, Michael

AU - Bodrogi, István

AU - Bokemeyer, Carsten

AU - Cavallin-Ståhl, Eva

AU - Classen, Johannes

AU - Clemm, Christoph

AU - Cohn-Cedermark, Gabriella

AU - Culine, Stéphane

AU - Daugaard, Gedske

AU - Mulder, De

AU - Pieter, H M

AU - Maria, De Santis

AU - de Wit, Maike

AU - de Wit, Ronald

AU - Derigs, Hans Günter

AU - Dieckmann, Klaus-Peter

AU - Dieing, Annette

AU - Droz, Jean-Pierre

AU - Fenner, Martin

AU - Fizazi, Karim

AU - Flechon, Aude

AU - Fosså, Sophie D

AU - Muro, Del

AU - Garcia, Xavier

AU - Gauler, Thomas

AU - Geczi, Lajos

AU - Gerl, Arthur

AU - Germa-Lluch, Jose Ramon

AU - Gillessen, Silke

AU - Hartmann, Jörg T

AU - Hartmann, Michael

AU - Heidenreich, Axel

AU - Hoeltl, Wolfgang

AU - Horwich, Alan

AU - Huddart, Robert

AU - Jewett, Michael

AU - Joffe, Johnathan

AU - Jones, William G

AU - Kisbenedek, László

AU - Klepp, Olbjørn

AU - Kliesch, Sabine

AU - Koehrmann, Kai Uwe

AU - Kollmannsberger, Christian

AU - Kuczyk, Markus

AU - Laguna, Pilar

AU - Galvis, Oscar Leiva

AU - Loy, Volker

AU - Mason, Malcolm D

AU - Mead, Graham M

AU - Mueller, Rolf

AU - Nichols, Craig

AU - Nicolai, Nicola

AU - Oliver, Tim

AU - Ondrus, Dalibor

AU - Oosterhof, Gosse O N

AU - Paz-Ares, Luis

AU - Pizzocaro, Giorgio

AU - Pont, Jörg

AU - Pottek, Tobias

AU - Powles, Tom

AU - Rick, Oliver

AU - Rosti, Giovanni

AU - Salvioni, Roberto

AU - Scheiderbauer, Jutta

AU - Schmelz, Hans-Ulrich

AU - Schmidberger, Heinz

AU - Schmoll, Hans-Joachim

AU - Schrader, Mark

AU - Sedlmayer, Felix

AU - Skakkebaek, Niels E

AU - Sohaib, Aslam

AU - Tjulandin, Sergei

AU - Warde, Padraig

AU - Weinknecht, Stefan

AU - Weissbach, Lothar

AU - Wittekind, Christian

AU - Winter, Eva

AU - Wood, Lori

AU - von der Maase, Hans

PY - 2008

Y1 - 2008

N2 - OBJECTIVES: The first consensus report that had been presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, The Netherlands. METHODS: Medical oncologists, urologic surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference and incorporated the new data into updated and revised guidelines. As for the first meeting the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. RESULTS: The second part of the consensus paper includes the treatment of metastasised disease, residual tumour resection, salvage therapy, follow-up, and late toxicities. CONCLUSIONS: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early-stage as well as of advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged.

AB - OBJECTIVES: The first consensus report that had been presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, The Netherlands. METHODS: Medical oncologists, urologic surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference and incorporated the new data into updated and revised guidelines. As for the first meeting the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. RESULTS: The second part of the consensus paper includes the treatment of metastasised disease, residual tumour resection, salvage therapy, follow-up, and late toxicities. CONCLUSIONS: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early-stage as well as of advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged.

M3 - SCORING: Zeitschriftenaufsatz

VL - 53

SP - 497

EP - 513

JO - EUR UROL

JF - EUR UROL

SN - 0302-2838

IS - 3

M1 - 3

ER -