Ethological analysis of the senescence-accelerated P/8 mouse
Standard
Ethological analysis of the senescence-accelerated P/8 mouse. / Brandewiede, Joerg; Schachner, Melitta; Morellini, Fabio.
In: BEHAV BRAIN RES, Vol. 158, No. 1, 07.03.2005, p. 109-21.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Ethological analysis of the senescence-accelerated P/8 mouse
AU - Brandewiede, Joerg
AU - Schachner, Melitta
AU - Morellini, Fabio
PY - 2005/3/7
Y1 - 2005/3/7
N2 - Behaviour of senescence-accelerated (P/8) and resistant (R/1) mice was assessed using an ethological approach in a longitudinal study for exploratory and anxiety related behaviours (home cage activity, open field, elevated plus-maze and new object tests), cognitive abilities (step-down and step-through passive avoidance and water maze tests) and visual acuity (visible cliff test). Overall, P/8 mice showed higher activity induced by new environmental stimuli, higher anxiety and lower novelty seeking behaviour in the new object test than R/1 mice. P/8 mice showed an impaired performance as compared to R/1 mice in two passive avoidance tasks. Behavioural alterations of P/8 mice were already apparent at the age of 10-12 weeks. Factor analyses indicated that the impairment of P/8 mice in passive avoidance tasks relates to their altered exploratory and anxiety-related behaviour rather than to cognitive impairments. In the water maze, both strains performed badly in the visible platform task, suggesting poor visual abilities in both strains as supported by the visible cliff test. We conclude that, for a better interpretation of cognitive abilities of P/8 mice, tests not based on novelty-induced behaviour, visual acuity and good motor skills should be used. Finally, we question whether P/8 mice could be a model of some forms of neuropsychiatric disorders resulting from developmental abnormalities rather than aging.
AB - Behaviour of senescence-accelerated (P/8) and resistant (R/1) mice was assessed using an ethological approach in a longitudinal study for exploratory and anxiety related behaviours (home cage activity, open field, elevated plus-maze and new object tests), cognitive abilities (step-down and step-through passive avoidance and water maze tests) and visual acuity (visible cliff test). Overall, P/8 mice showed higher activity induced by new environmental stimuli, higher anxiety and lower novelty seeking behaviour in the new object test than R/1 mice. P/8 mice showed an impaired performance as compared to R/1 mice in two passive avoidance tasks. Behavioural alterations of P/8 mice were already apparent at the age of 10-12 weeks. Factor analyses indicated that the impairment of P/8 mice in passive avoidance tasks relates to their altered exploratory and anxiety-related behaviour rather than to cognitive impairments. In the water maze, both strains performed badly in the visible platform task, suggesting poor visual abilities in both strains as supported by the visible cliff test. We conclude that, for a better interpretation of cognitive abilities of P/8 mice, tests not based on novelty-induced behaviour, visual acuity and good motor skills should be used. Finally, we question whether P/8 mice could be a model of some forms of neuropsychiatric disorders resulting from developmental abnormalities rather than aging.
KW - Age Factors
KW - Aging
KW - Analysis of Variance
KW - Animals
KW - Anxiety
KW - Avoidance Learning
KW - Behavior, Animal
KW - Cognition
KW - Ethology
KW - Exploratory Behavior
KW - Factor Analysis, Statistical
KW - Locomotion
KW - Maze Learning
KW - Mice
KW - Mice, Neurologic Mutants
KW - Psychomotor Performance
KW - Reaction Time
KW - Species Specificity
KW - Time Factors
KW - Visual Acuity
U2 - 10.1016/j.bbr.2004.08.012
DO - 10.1016/j.bbr.2004.08.012
M3 - SCORING: Journal article
C2 - 15680199
VL - 158
SP - 109
EP - 121
JO - BEHAV BRAIN RES
JF - BEHAV BRAIN RES
SN - 0166-4328
IS - 1
ER -