Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function.

Manja Reimann; Tjalf Ziemssen; Hugo W Huisman; Rudolph Schutte; Leoné Malan; Van Rooyen; Rainer Böger; Rainer H Böger; Nicolaas T Malan; Aletta E Schutte

Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function.

Standard

Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function. / Reimann, Manja; Ziemssen, Tjalf; Huisman, Hugo W; Schutte, Rudolph; Malan, Leoné; Rooyen, Van; Böger, Rainer; Böger, Rainer H; Malan, Nicolaas T; Schutte, Aletta E.

In: OBESITY, Vol. 17, No. 12, 12, 2009, p. 2210-2215.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Reimann, M, Ziemssen, T, Huisman, HW, Schutte, R, Malan, L, Rooyen, V, Böger, R, Böger, RH, Malan, NT & Schutte, AE 2009, 'Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function.', OBESITY, vol. 17, no. 12, 12, pp. 2210-2215. <http://www.ncbi.nlm.nih.gov/pubmed/19444230?dopt=Citation>

APA

Reimann, M., Ziemssen, T., Huisman, H. W., Schutte, R., Malan, L., Rooyen, V., Böger, R., Böger, R. H., Malan, N. T., & Schutte, A. E. (2009). Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function. OBESITY, 17(12), 2210-2215. [12]. http://www.ncbi.nlm.nih.gov/pubmed/19444230?dopt=Citation

Vancouver

Reimann M, Ziemssen T, Huisman HW, Schutte R, Malan L, Rooyen V et al. Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function. OBESITY. 2009;17(12):2210-2215. 12.

Bibtex

@article{16d72727b10646858d8b62cee89646e2,

title = "Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function.",

abstract = "Sub-Saharan Africa is afflicted by high hypertension prevalence that is expected to rise even further along with increasing obesity rates. The present study aimed to investigate the role of visfatin in obesity and to explore associations of visfatin with markers of endothelial function and hemodynamics in African women compared to a well-matched white sample. The present study involved urban African (n = 102) and white (n = 115) women from South Africa, individually matched for age and BMI. We measured blood pressure, cardiac output, and arterial compliance noninvasively, and analyzed visfatin as well as circulating markers of vascular function and inflammation in serum. Serum visfatin concentration did not differ between African and white women. Visfatin was unrelated to obesity in African women but positive associations for total and abdominal obesity were found in white women. Age- and obesity-adjusted univariate and multivariate analyses revealed significant positive associations of visfatin with endothelin-1 and fibrinogen in African women. Identical analyses in white women indicated a positive association of visfatin with C-reactive protein and von Willebrand factor. Our findings suggest a possible role of visfatin in the cardiovascular system that seems to be independent of obesity in the African women.",

keywords = "Adult, Humans, Female, Young Adult, African Continental Ancestry Group, Biological Markers blood, C-Reactive Protein metabolism, Endothelin-1 blood, Endothelium, Vascular physiopathology, European Continental Ancestry Group, Fibrinogen metabolism, Inflammation blood, Nicotinamide Phosphoribosyltransferase blood, Obesity blood, Obesity, Abdominal blood, South Africa, von Willebrand Factor metabolism, Adult, Humans, Female, Young Adult, African Continental Ancestry Group, Biological Markers blood, C-Reactive Protein metabolism, Endothelin-1 blood, Endothelium, Vascular physiopathology, European Continental Ancestry Group, Fibrinogen metabolism, Inflammation blood, Nicotinamide Phosphoribosyltransferase blood, Obesity blood, Obesity, Abdominal blood, South Africa, von Willebrand Factor metabolism",

author = "Manja Reimann and Tjalf Ziemssen and Huisman, {Hugo W} and Rudolph Schutte and Leon{\'e} Malan and Van Rooyen and Rainer B{\"o}ger and B{\"o}ger, {Rainer H} and Malan, {Nicolaas T} and Schutte, {Aletta E}",

year = "2009",

language = "Deutsch",

volume = "17",

pages = "2210--2215",

number = "12",

}

RIS

TY - JOUR

T1 - Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function.

AU - Reimann, Manja

AU - Ziemssen, Tjalf

AU - Huisman, Hugo W

AU - Schutte, Rudolph

AU - Malan, Leoné

AU - Rooyen, Van

AU - Böger, Rainer

AU - Böger, Rainer H

AU - Malan, Nicolaas T

AU - Schutte, Aletta E

PY - 2009

Y1 - 2009

N2 - Sub-Saharan Africa is afflicted by high hypertension prevalence that is expected to rise even further along with increasing obesity rates. The present study aimed to investigate the role of visfatin in obesity and to explore associations of visfatin with markers of endothelial function and hemodynamics in African women compared to a well-matched white sample. The present study involved urban African (n = 102) and white (n = 115) women from South Africa, individually matched for age and BMI. We measured blood pressure, cardiac output, and arterial compliance noninvasively, and analyzed visfatin as well as circulating markers of vascular function and inflammation in serum. Serum visfatin concentration did not differ between African and white women. Visfatin was unrelated to obesity in African women but positive associations for total and abdominal obesity were found in white women. Age- and obesity-adjusted univariate and multivariate analyses revealed significant positive associations of visfatin with endothelin-1 and fibrinogen in African women. Identical analyses in white women indicated a positive association of visfatin with C-reactive protein and von Willebrand factor. Our findings suggest a possible role of visfatin in the cardiovascular system that seems to be independent of obesity in the African women.

AB - Sub-Saharan Africa is afflicted by high hypertension prevalence that is expected to rise even further along with increasing obesity rates. The present study aimed to investigate the role of visfatin in obesity and to explore associations of visfatin with markers of endothelial function and hemodynamics in African women compared to a well-matched white sample. The present study involved urban African (n = 102) and white (n = 115) women from South Africa, individually matched for age and BMI. We measured blood pressure, cardiac output, and arterial compliance noninvasively, and analyzed visfatin as well as circulating markers of vascular function and inflammation in serum. Serum visfatin concentration did not differ between African and white women. Visfatin was unrelated to obesity in African women but positive associations for total and abdominal obesity were found in white women. Age- and obesity-adjusted univariate and multivariate analyses revealed significant positive associations of visfatin with endothelin-1 and fibrinogen in African women. Identical analyses in white women indicated a positive association of visfatin with C-reactive protein and von Willebrand factor. Our findings suggest a possible role of visfatin in the cardiovascular system that seems to be independent of obesity in the African women.

KW - Adult

KW - Humans

KW - Female

KW - Young Adult

KW - African Continental Ancestry Group

KW - Biological Markers blood

KW - C-Reactive Protein metabolism

KW - Endothelin-1 blood

KW - Endothelium, Vascular physiopathology

KW - European Continental Ancestry Group

KW - Fibrinogen metabolism

KW - Inflammation blood

KW - Nicotinamide Phosphoribosyltransferase blood

KW - Obesity blood

KW - Obesity, Abdominal blood

KW - South Africa

KW - von Willebrand Factor metabolism