Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
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Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. / Mente, Andrew; Razak, Fahad; Blankenberg, Stefan; Vuksan, Vlad; Davis, A Darlene; Miller, Ruby; Teo, Koon; Gerstein, Hertzel; Sharma, Arya M; Yusuf, Salim; Anand, Sonia S; Study of the Health Assessment And Risk Evaluation.
In: DIABETES CARE, Vol. 33, No. 7, 07.2010, p. 1629-1634.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
AU - Mente, Andrew
AU - Razak, Fahad
AU - Blankenberg, Stefan
AU - Vuksan, Vlad
AU - Davis, A Darlene
AU - Miller, Ruby
AU - Teo, Koon
AU - Gerstein, Hertzel
AU - Sharma, Arya M
AU - Yusuf, Salim
AU - Anand, Sonia S
AU - Study of the Health Assessment And Risk Evaluation
PY - 2010/7
Y1 - 2010/7
N2 - OBJECTIVE: To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance.RESEARCH DESIGN AND METHODS: In 1,176 South Asian, Chinese, Aboriginal, and European Canadians, fasting blood samples were drawn, and clinical history and dietary habits including glycemic index/glycemic load were recorded using standardized questionnaires. Insulin resistance was defined using homeostasis model assessment-insulin resistance (HOMA-IR).RESULTS: Adiponectin concentrations were significantly higher in Europeans (adjusted mean 12.94 [95% CI 2.27-13.64]) and Aboriginal people (11.87 [11.19-12.59]) than in South Asians (9.35 [8.82-9.92]) and Chinese (8.52 [8.03-9.03]) (overall P < 0.001). Serum leptin was significantly higher in South Asians (11.82 [10.72-13.04]) and Aboriginal people (11.13 [10.13-12.23]) than in Europeans (9.21 [8.38-10.12]) and Chinese (8.25 [7.48-9.10]). BMI and waist circumference were inversely associated with adiponectin in every group except the South Asians (P < 0.001 for interaction). Adiponectin was inversely and leptin was positively associated with HOMA-IR (P < 0.001). The increase in HOMA-IR for each given decrease in adiponectin was larger among South Asians (P = 0.01) and Aboriginal people (P < 0.001) than among Europeans. A high glycemic index was associated with a larger decrease in adiponectin among South Asians (P = 0.03) and Aboriginal people (P < 0.001) and a larger increase in HOMA-IR among South Asians (P < 0.05) relative to that in other groups.CONCLUSIONS: South Asians have the least favorable adipokine profile and, like the Aboriginal people, display a greater increase in insulin resistance with decreasing levels of adiponectin. Differences in adipokines and responses to glycemic foods parallel the ethnic differences in insulin resistance.
AB - OBJECTIVE: To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance.RESEARCH DESIGN AND METHODS: In 1,176 South Asian, Chinese, Aboriginal, and European Canadians, fasting blood samples were drawn, and clinical history and dietary habits including glycemic index/glycemic load were recorded using standardized questionnaires. Insulin resistance was defined using homeostasis model assessment-insulin resistance (HOMA-IR).RESULTS: Adiponectin concentrations were significantly higher in Europeans (adjusted mean 12.94 [95% CI 2.27-13.64]) and Aboriginal people (11.87 [11.19-12.59]) than in South Asians (9.35 [8.82-9.92]) and Chinese (8.52 [8.03-9.03]) (overall P < 0.001). Serum leptin was significantly higher in South Asians (11.82 [10.72-13.04]) and Aboriginal people (11.13 [10.13-12.23]) than in Europeans (9.21 [8.38-10.12]) and Chinese (8.25 [7.48-9.10]). BMI and waist circumference were inversely associated with adiponectin in every group except the South Asians (P < 0.001 for interaction). Adiponectin was inversely and leptin was positively associated with HOMA-IR (P < 0.001). The increase in HOMA-IR for each given decrease in adiponectin was larger among South Asians (P = 0.01) and Aboriginal people (P < 0.001) than among Europeans. A high glycemic index was associated with a larger decrease in adiponectin among South Asians (P = 0.03) and Aboriginal people (P < 0.001) and a larger increase in HOMA-IR among South Asians (P < 0.05) relative to that in other groups.CONCLUSIONS: South Asians have the least favorable adipokine profile and, like the Aboriginal people, display a greater increase in insulin resistance with decreasing levels of adiponectin. Differences in adipokines and responses to glycemic foods parallel the ethnic differences in insulin resistance.
KW - Adiponectin/blood
KW - Adiposity/ethnology
KW - Adult
KW - Aged
KW - Asian Continental Ancestry Group/statistics & numerical data
KW - Canada/epidemiology
KW - Continental Population Groups/statistics & numerical data
KW - Diabetes Mellitus, Type 2/ethnology
KW - European Continental Ancestry Group/statistics & numerical data
KW - Feeding Behavior
KW - Female
KW - Glycemic Index/ethnology
KW - Homeostasis/physiology
KW - Humans
KW - Indians, North American/statistics & numerical data
KW - Insulin Resistance
KW - Leptin/blood
KW - Male
KW - Middle Aged
KW - Risk Factors
KW - Surveys and Questionnaires
U2 - 10.2337/dc09-1392
DO - 10.2337/dc09-1392
M3 - SCORING: Journal article
C2 - 20413520
VL - 33
SP - 1629
EP - 1634
JO - DIABETES CARE
JF - DIABETES CARE
SN - 0149-5992
IS - 7
ER -
