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Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice

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Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice. / Nolan, Lisa S; Maier, Hannes; Hermans-Borgmeyer, Irm; Girotto, Giorgia; Ecob, Russell; Pirastu, Nicola; Cadge, Barbara A; Hübner, Christian; Gasparini, Paolo; Strachan, David P; Davis, Adrian; Dawson, Sally J.

In: NEUROBIOL AGING, Vol. 34, No. 8, 01.08.2013, p. 2077.e1-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nolan, LS, Maier, H, Hermans-Borgmeyer, I, Girotto, G, Ecob, R, Pirastu, N, Cadge, BA, Hübner, C, Gasparini, P, Strachan, DP, Davis, A & Dawson, SJ 2013, 'Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice', NEUROBIOL AGING, vol. 34, no. 8, pp. 2077.e1-9. https://doi.org/10.1016/j.neurobiolaging.2013.02.009

APA

Nolan, L. S., Maier, H., Hermans-Borgmeyer, I., Girotto, G., Ecob, R., Pirastu, N., Cadge, B. A., Hübner, C., Gasparini, P., Strachan, D. P., Davis, A., & Dawson, S. J. (2013). Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice. NEUROBIOL AGING, 34(8), 2077.e1-9. https://doi.org/10.1016/j.neurobiolaging.2013.02.009

Vancouver

Nolan LS, Maier H, Hermans-Borgmeyer I, Girotto G, Ecob R, Pirastu N et al. Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice. NEUROBIOL AGING. 2013 Aug 1;34(8):2077.e1-9. https://doi.org/10.1016/j.neurobiolaging.2013.02.009

Bibtex

@article{09ced5ce02c74e4881c6ba0335a49505,
title = "Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice",
abstract = "Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice.",
keywords = "Adult, Animals, Case-Control Studies, Cohort Studies, Ear, Inner, Female, Genetic Association Studies, Hearing, Hearing Loss, Humans, Male, Mice, Mice, Inbred C57BL, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Estrogen, Sex Factors",
author = "Nolan, {Lisa S} and Hannes Maier and Irm Hermans-Borgmeyer and Giorgia Girotto and Russell Ecob and Nicola Pirastu and Cadge, {Barbara A} and Christian H{\"u}bner and Paolo Gasparini and Strachan, {David P} and Adrian Davis and Dawson, {Sally J}",
note = "Copyright {\textcopyright} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
month = aug,
day = "1",
doi = "10.1016/j.neurobiolaging.2013.02.009",
language = "English",
volume = "34",
pages = "2077.e1--9",
journal = "NEUROBIOL AGING",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice

AU - Nolan, Lisa S

AU - Maier, Hannes

AU - Hermans-Borgmeyer, Irm

AU - Girotto, Giorgia

AU - Ecob, Russell

AU - Pirastu, Nicola

AU - Cadge, Barbara A

AU - Hübner, Christian

AU - Gasparini, Paolo

AU - Strachan, David P

AU - Davis, Adrian

AU - Dawson, Sally J

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice.

AB - Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice.

KW - Adult

KW - Animals

KW - Case-Control Studies

KW - Cohort Studies

KW - Ear, Inner

KW - Female

KW - Genetic Association Studies

KW - Hearing

KW - Hearing Loss

KW - Humans

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Receptors, Estrogen

KW - Sex Factors

U2 - 10.1016/j.neurobiolaging.2013.02.009

DO - 10.1016/j.neurobiolaging.2013.02.009

M3 - SCORING: Journal article

C2 - 23540940

VL - 34

SP - 2077.e1-9

JO - NEUROBIOL AGING

JF - NEUROBIOL AGING

SN - 0197-4580

IS - 8

ER -