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Estrogen receptor gene amplification occurs rarely in ovarian cancer.

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Estrogen receptor gene amplification occurs rarely in ovarian cancer. / Issa, Rana; Lebeau, Annette; Grob, Tobias; Holst, Frederik; Moch, Holger; Terracciano, Luigi; Choschzick, Matthias; Sauter, Guido; Simon, Ronald.

In: MODERN PATHOL, 2008.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Issa, R, Lebeau, A, Grob, T, Holst, F, Moch, H, Terracciano, L, Choschzick, M, Sauter, G & Simon, R 2008, 'Estrogen receptor gene amplification occurs rarely in ovarian cancer.', MODERN PATHOL. <http://www.ncbi.nlm.nih.gov/pubmed/18690166?dopt=Citation>

APA

Issa, R., Lebeau, A., Grob, T., Holst, F., Moch, H., Terracciano, L., Choschzick, M., Sauter, G., & Simon, R. (2008). Estrogen receptor gene amplification occurs rarely in ovarian cancer. MODERN PATHOL. http://www.ncbi.nlm.nih.gov/pubmed/18690166?dopt=Citation

Vancouver

Issa R, Lebeau A, Grob T, Holst F, Moch H, Terracciano L et al. Estrogen receptor gene amplification occurs rarely in ovarian cancer. MODERN PATHOL. 2008.

Bibtex

@article{25d0e74e61c646f2bb79b7a40f24ea4f,
title = "Estrogen receptor gene amplification occurs rarely in ovarian cancer.",
abstract = "Amplification of the gene encoding estrogen receptor-alpha occurs in about 20% of breast cancers and is an important mechanism for estrogen receptor overexpression in this tumor type. In ovarian cancer, overexpression of estrogen receptor protein has been described in more than two thirds of cases. To study a potential role of estrogen receptor-alpha gene amplification for estrogen receptor overexpression in ovarian cancer, a tumor tissue microarray containing 428 ovarian cancers was analyzed by fluorescence in situ hybridization for estrogen receptor-alpha gene amplification and immunohistochemistry for estrogen receptor expression. The estrogen receptor-alpha gene status was successfully determined in 243 of 428 arrayed cancers. Estrogen receptor gene amplification was found in 5 of 243 (2%) of tumors. Amplification levels were usually low, with 4-8 estrogen receptor-alpha gene copies. However, one case had a high-level amplification, with more than 30 estrogen receptor-alpha gene copies. All five amplified tumors were estrogen receptor positive, with 3 of 5 tumors showing highest (Allred score, 7-8) estrogen receptor levels. The data demonstrate that estrogen receptor-alpha amplification occurs only rarely in ovarian cancer.Modern Pathology advance online publication, 8 August 2008; doi:10.1038/modpathol.2008.130.",
author = "Rana Issa and Annette Lebeau and Tobias Grob and Frederik Holst and Holger Moch and Luigi Terracciano and Matthias Choschzick and Guido Sauter and Ronald Simon",
year = "2008",
language = "Deutsch",
journal = "MODERN PATHOL",
issn = "0893-3952",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Estrogen receptor gene amplification occurs rarely in ovarian cancer.

AU - Issa, Rana

AU - Lebeau, Annette

AU - Grob, Tobias

AU - Holst, Frederik

AU - Moch, Holger

AU - Terracciano, Luigi

AU - Choschzick, Matthias

AU - Sauter, Guido

AU - Simon, Ronald

PY - 2008

Y1 - 2008

N2 - Amplification of the gene encoding estrogen receptor-alpha occurs in about 20% of breast cancers and is an important mechanism for estrogen receptor overexpression in this tumor type. In ovarian cancer, overexpression of estrogen receptor protein has been described in more than two thirds of cases. To study a potential role of estrogen receptor-alpha gene amplification for estrogen receptor overexpression in ovarian cancer, a tumor tissue microarray containing 428 ovarian cancers was analyzed by fluorescence in situ hybridization for estrogen receptor-alpha gene amplification and immunohistochemistry for estrogen receptor expression. The estrogen receptor-alpha gene status was successfully determined in 243 of 428 arrayed cancers. Estrogen receptor gene amplification was found in 5 of 243 (2%) of tumors. Amplification levels were usually low, with 4-8 estrogen receptor-alpha gene copies. However, one case had a high-level amplification, with more than 30 estrogen receptor-alpha gene copies. All five amplified tumors were estrogen receptor positive, with 3 of 5 tumors showing highest (Allred score, 7-8) estrogen receptor levels. The data demonstrate that estrogen receptor-alpha amplification occurs only rarely in ovarian cancer.Modern Pathology advance online publication, 8 August 2008; doi:10.1038/modpathol.2008.130.

AB - Amplification of the gene encoding estrogen receptor-alpha occurs in about 20% of breast cancers and is an important mechanism for estrogen receptor overexpression in this tumor type. In ovarian cancer, overexpression of estrogen receptor protein has been described in more than two thirds of cases. To study a potential role of estrogen receptor-alpha gene amplification for estrogen receptor overexpression in ovarian cancer, a tumor tissue microarray containing 428 ovarian cancers was analyzed by fluorescence in situ hybridization for estrogen receptor-alpha gene amplification and immunohistochemistry for estrogen receptor expression. The estrogen receptor-alpha gene status was successfully determined in 243 of 428 arrayed cancers. Estrogen receptor gene amplification was found in 5 of 243 (2%) of tumors. Amplification levels were usually low, with 4-8 estrogen receptor-alpha gene copies. However, one case had a high-level amplification, with more than 30 estrogen receptor-alpha gene copies. All five amplified tumors were estrogen receptor positive, with 3 of 5 tumors showing highest (Allred score, 7-8) estrogen receptor levels. The data demonstrate that estrogen receptor-alpha amplification occurs only rarely in ovarian cancer.Modern Pathology advance online publication, 8 August 2008; doi:10.1038/modpathol.2008.130.

M3 - SCORING: Zeitschriftenaufsatz

JO - MODERN PATHOL

JF - MODERN PATHOL

SN - 0893-3952

ER -