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Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer.

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Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. / Holst, Frederik; Stahl, Phillip; Ruiz, Christian; Hellwinkel, Olaf; Jehan, Zeenath; Wendland, Marc; Lebeau, Annette; Terracciano, Luigi; Al-Kuraya, Khawla; Jänicke, Fritz; Sauter, Guido; Simon, Ronald.

In: NAT GENET, Vol. 39, No. 5, 5, 2007, p. 655-660.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Holst, F, Stahl, P, Ruiz, C, Hellwinkel, O, Jehan, Z, Wendland, M, Lebeau, A, Terracciano, L, Al-Kuraya, K, Jänicke, F, Sauter, G & Simon, R 2007, 'Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer.', NAT GENET, vol. 39, no. 5, 5, pp. 655-660. <http://www.ncbi.nlm.nih.gov/pubmed/17417639?dopt=Citation>

APA

Holst, F., Stahl, P., Ruiz, C., Hellwinkel, O., Jehan, Z., Wendland, M., Lebeau, A., Terracciano, L., Al-Kuraya, K., Jänicke, F., Sauter, G., & Simon, R. (2007). Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. NAT GENET, 39(5), 655-660. [5]. http://www.ncbi.nlm.nih.gov/pubmed/17417639?dopt=Citation

Vancouver

Holst F, Stahl P, Ruiz C, Hellwinkel O, Jehan Z, Wendland M et al. Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. NAT GENET. 2007;39(5):655-660. 5.

Bibtex

@article{762eecb3064a4303a362035586ec9fb3,
title = "Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer.",
abstract = "Using an Affymetrix 10K SNP array to screen for gene copy number changes in breast cancer, we detected a single-gene amplification of the ESR1 gene, which encodes estrogen receptor alpha, at 6q25. A subsequent tissue microarray analysis of more than 2,000 clinical breast cancer samples showed ESR1 amplification in 20.6% of breast cancers. Ninety-nine percent of tumors with ESR1 amplification showed estrogen receptor protein overexpression, compared with 66.6% cancers without ESR1 amplification (P <0.0001). In 175 women who had received adjuvant tamoxifen monotherapy, survival was significantly longer for women with cancer with ESR1 amplification than for women with estrogen receptor-expressing cancers without ESR1 amplification (P = 0.023). Notably, we also found ESR1 amplification in benign and precancerous breast diseases, suggesting that ESR1 amplification may be a common mechanism in proliferative breast disease and a very early genetic alteration in a large subset of breast cancers.",
author = "Frederik Holst and Phillip Stahl and Christian Ruiz and Olaf Hellwinkel and Zeenath Jehan and Marc Wendland and Annette Lebeau and Luigi Terracciano and Khawla Al-Kuraya and Fritz J{\"a}nicke and Guido Sauter and Ronald Simon",
year = "2007",
language = "Deutsch",
volume = "39",
pages = "655--660",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer.

AU - Holst, Frederik

AU - Stahl, Phillip

AU - Ruiz, Christian

AU - Hellwinkel, Olaf

AU - Jehan, Zeenath

AU - Wendland, Marc

AU - Lebeau, Annette

AU - Terracciano, Luigi

AU - Al-Kuraya, Khawla

AU - Jänicke, Fritz

AU - Sauter, Guido

AU - Simon, Ronald

PY - 2007

Y1 - 2007

N2 - Using an Affymetrix 10K SNP array to screen for gene copy number changes in breast cancer, we detected a single-gene amplification of the ESR1 gene, which encodes estrogen receptor alpha, at 6q25. A subsequent tissue microarray analysis of more than 2,000 clinical breast cancer samples showed ESR1 amplification in 20.6% of breast cancers. Ninety-nine percent of tumors with ESR1 amplification showed estrogen receptor protein overexpression, compared with 66.6% cancers without ESR1 amplification (P <0.0001). In 175 women who had received adjuvant tamoxifen monotherapy, survival was significantly longer for women with cancer with ESR1 amplification than for women with estrogen receptor-expressing cancers without ESR1 amplification (P = 0.023). Notably, we also found ESR1 amplification in benign and precancerous breast diseases, suggesting that ESR1 amplification may be a common mechanism in proliferative breast disease and a very early genetic alteration in a large subset of breast cancers.

AB - Using an Affymetrix 10K SNP array to screen for gene copy number changes in breast cancer, we detected a single-gene amplification of the ESR1 gene, which encodes estrogen receptor alpha, at 6q25. A subsequent tissue microarray analysis of more than 2,000 clinical breast cancer samples showed ESR1 amplification in 20.6% of breast cancers. Ninety-nine percent of tumors with ESR1 amplification showed estrogen receptor protein overexpression, compared with 66.6% cancers without ESR1 amplification (P <0.0001). In 175 women who had received adjuvant tamoxifen monotherapy, survival was significantly longer for women with cancer with ESR1 amplification than for women with estrogen receptor-expressing cancers without ESR1 amplification (P = 0.023). Notably, we also found ESR1 amplification in benign and precancerous breast diseases, suggesting that ESR1 amplification may be a common mechanism in proliferative breast disease and a very early genetic alteration in a large subset of breast cancers.

M3 - SCORING: Zeitschriftenaufsatz

VL - 39

SP - 655

EP - 660

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 5

M1 - 5

ER -