Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.
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Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone. / Illing, Anett; Liu, Peng; Ostermay, Susanne; Schilling, Arndt; de Haan, Gerald; Krust, Andree; Amling, Michael; Chambon, Pierre; Schinke, Thorsten; Tuckermann, Jan P.
In: HAEMATOLOGICA, Vol. 97, No. 8, 8, 2012, p. 1131-1135.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.
AU - Illing, Anett
AU - Liu, Peng
AU - Ostermay, Susanne
AU - Schilling, Arndt
AU - de Haan, Gerald
AU - Krust, Andree
AU - Amling, Michael
AU - Chambon, Pierre
AU - Schinke, Thorsten
AU - Tuckermann, Jan P
PY - 2012
Y1 - 2012
N2 - Hematopoietic stem and progenitor cells reside in vascular and endosteal niches in the bone marrow. Factors affecting bone remodeling were reported to influence numbers and mobilization of hematopoietic stem cells. We therefore analyzed the effects of estradiol acting anabolic on bone integrity. Here we observe that estradiol increases progenitor cell numbers in the vascular but not in the endosteal compartment independent of its estrogen receptor ?-dependent anabolic bone effects. Hematopoietic progenitors capable of reconstituting lethally irradiated mice are increased by enhanced cell cycle entry, leading to a diminished long-term reconstitution potential after serial transplantation. We demonstrate that estradiol action on stromal cells potently favors hematopoietic progenitor/stem cell frequency accompanied by enhanced expression of cell adhesion molecules. Finally, estradiol treatment enhances retention of hematopoietic stem cells in the vascular niche of the bone marrow. We describe for the first time the mechanism of estrogen action on hematopoietic stem and progenitor cells.
AB - Hematopoietic stem and progenitor cells reside in vascular and endosteal niches in the bone marrow. Factors affecting bone remodeling were reported to influence numbers and mobilization of hematopoietic stem cells. We therefore analyzed the effects of estradiol acting anabolic on bone integrity. Here we observe that estradiol increases progenitor cell numbers in the vascular but not in the endosteal compartment independent of its estrogen receptor ?-dependent anabolic bone effects. Hematopoietic progenitors capable of reconstituting lethally irradiated mice are increased by enhanced cell cycle entry, leading to a diminished long-term reconstitution potential after serial transplantation. We demonstrate that estradiol action on stromal cells potently favors hematopoietic progenitor/stem cell frequency accompanied by enhanced expression of cell adhesion molecules. Finally, estradiol treatment enhances retention of hematopoietic stem cells in the vascular niche of the bone marrow. We describe for the first time the mechanism of estrogen action on hematopoietic stem and progenitor cells.
KW - Animals
KW - Female
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Bone Marrow Cells/cytology/drug effects
KW - Bone and Bones/drug effects
KW - Estradiol/pharmacology
KW - Estrogen Receptor alpha/genetics/metabolism
KW - Estrogen Receptor beta/genetics/metabolism
KW - Hematopoietic Stem Cells/cytology/drug effects/metabolism
KW - Stem Cell Niche/drug effects
KW - Animals
KW - Female
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Bone Marrow Cells/cytology/drug effects
KW - Bone and Bones/drug effects
KW - Estradiol/pharmacology
KW - Estrogen Receptor alpha/genetics/metabolism
KW - Estrogen Receptor beta/genetics/metabolism
KW - Hematopoietic Stem Cells/cytology/drug effects/metabolism
KW - Stem Cell Niche/drug effects
U2 - 10.3324/haematol.2011.052456
DO - 10.3324/haematol.2011.052456
M3 - SCORING: Journal article
VL - 97
SP - 1131
EP - 1135
JO - HAEMATOLOGICA
JF - HAEMATOLOGICA
SN - 0390-6078
IS - 8
M1 - 8
ER -
