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Estimating infectiousness throughout SARS-CoV-2 infection course

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Estimating infectiousness throughout SARS-CoV-2 infection course. / Jones, Terry C; Biele, Guido; Mühlemann, Barbara; Veith, Talitha; Schneider, Julia; Beheim-Schwarzbach, Jörn; Bleicker, Tobias; Tesch, Julia; Schmidt, Marie Luisa; Sander, Leif Erik; Kurth, Florian; Menzel, Peter; Schwarzer, Rolf; Zuchowski, Marta; Hofmann, Jörg; Krumbholz, Andi; Stein, Angela; Edelmann, Anke; Corman, Victor Max; Drosten, Christian.

In: SCIENCE, Vol. 373, No. 6551, eabi5273, 09.07.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jones, TC, Biele, G, Mühlemann, B, Veith, T, Schneider, J, Beheim-Schwarzbach, J, Bleicker, T, Tesch, J, Schmidt, ML, Sander, LE, Kurth, F, Menzel, P, Schwarzer, R, Zuchowski, M, Hofmann, J, Krumbholz, A, Stein, A, Edelmann, A, Corman, VM & Drosten, C 2021, 'Estimating infectiousness throughout SARS-CoV-2 infection course', SCIENCE, vol. 373, no. 6551, eabi5273. https://doi.org/10.1126/science.abi5273

APA

Jones, T. C., Biele, G., Mühlemann, B., Veith, T., Schneider, J., Beheim-Schwarzbach, J., Bleicker, T., Tesch, J., Schmidt, M. L., Sander, L. E., Kurth, F., Menzel, P., Schwarzer, R., Zuchowski, M., Hofmann, J., Krumbholz, A., Stein, A., Edelmann, A., Corman, V. M., & Drosten, C. (2021). Estimating infectiousness throughout SARS-CoV-2 infection course. SCIENCE, 373(6551), [eabi5273]. https://doi.org/10.1126/science.abi5273

Vancouver

Jones TC, Biele G, Mühlemann B, Veith T, Schneider J, Beheim-Schwarzbach J et al. Estimating infectiousness throughout SARS-CoV-2 infection course. SCIENCE. 2021 Jul 9;373(6551). eabi5273. https://doi.org/10.1126/science.abi5273

Bibtex

@article{3cee555ce78641389f29962dbf8b0a09,
title = "Estimating infectiousness throughout SARS-CoV-2 infection course",
abstract = "Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Germany, including 6110 from test centers attended by presymptomatic, asymptomatic, and mildly symptomatic (PAMS) subjects, 9519 who were hospitalized, and 1533 B.1.1.7 lineage infections. The viral load of the youngest subjects was lower than that of the older subjects by 0.5 (or fewer) log10 units, and they displayed an estimated ~78% of the peak cell culture replication probability; in part this was due to smaller swab sizes and unlikely to be clinically relevant. Viral loads above 109 copies per swab were found in 8% of subjects, one-third of whom were PAMS, with a mean age of 37.6 years. We estimate 4.3 days from onset of shedding to peak viral load (108.1 RNA copies per swab) and peak cell culture isolation probability (0.75). B.1.1.7 subjects had mean log10 viral load 1.05 higher than that of non-B.1.1.7 subjects, and the estimated cell culture replication probability of B.1.1.7 subjects was higher by a factor of 2.6.",
keywords = "Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Asymptomatic Infections, COVID-19/diagnosis, COVID-19 Nucleic Acid Testing, Caco-2 Cells, Child, Child, Preschool, Female, Germany, Hospitalization, Humans, Infant, Male, Middle Aged, Probability, SARS-CoV-2/isolation & purification, Viral Load, Virus Replication, Virus Shedding, Young Adult",
author = "Jones, {Terry C} and Guido Biele and Barbara M{\"u}hlemann and Talitha Veith and Julia Schneider and J{\"o}rn Beheim-Schwarzbach and Tobias Bleicker and Julia Tesch and Schmidt, {Marie Luisa} and Sander, {Leif Erik} and Florian Kurth and Peter Menzel and Rolf Schwarzer and Marta Zuchowski and J{\"o}rg Hofmann and Andi Krumbholz and Angela Stein and Anke Edelmann and Corman, {Victor Max} and Christian Drosten",
note = "Copyright {\textcopyright} 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2021",
month = jul,
day = "9",
doi = "10.1126/science.abi5273",
language = "English",
volume = "373",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6551",

}

RIS

TY - JOUR

T1 - Estimating infectiousness throughout SARS-CoV-2 infection course

AU - Jones, Terry C

AU - Biele, Guido

AU - Mühlemann, Barbara

AU - Veith, Talitha

AU - Schneider, Julia

AU - Beheim-Schwarzbach, Jörn

AU - Bleicker, Tobias

AU - Tesch, Julia

AU - Schmidt, Marie Luisa

AU - Sander, Leif Erik

AU - Kurth, Florian

AU - Menzel, Peter

AU - Schwarzer, Rolf

AU - Zuchowski, Marta

AU - Hofmann, Jörg

AU - Krumbholz, Andi

AU - Stein, Angela

AU - Edelmann, Anke

AU - Corman, Victor Max

AU - Drosten, Christian

N1 - Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2021/7/9

Y1 - 2021/7/9

N2 - Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Germany, including 6110 from test centers attended by presymptomatic, asymptomatic, and mildly symptomatic (PAMS) subjects, 9519 who were hospitalized, and 1533 B.1.1.7 lineage infections. The viral load of the youngest subjects was lower than that of the older subjects by 0.5 (or fewer) log10 units, and they displayed an estimated ~78% of the peak cell culture replication probability; in part this was due to smaller swab sizes and unlikely to be clinically relevant. Viral loads above 109 copies per swab were found in 8% of subjects, one-third of whom were PAMS, with a mean age of 37.6 years. We estimate 4.3 days from onset of shedding to peak viral load (108.1 RNA copies per swab) and peak cell culture isolation probability (0.75). B.1.1.7 subjects had mean log10 viral load 1.05 higher than that of non-B.1.1.7 subjects, and the estimated cell culture replication probability of B.1.1.7 subjects was higher by a factor of 2.6.

AB - Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Germany, including 6110 from test centers attended by presymptomatic, asymptomatic, and mildly symptomatic (PAMS) subjects, 9519 who were hospitalized, and 1533 B.1.1.7 lineage infections. The viral load of the youngest subjects was lower than that of the older subjects by 0.5 (or fewer) log10 units, and they displayed an estimated ~78% of the peak cell culture replication probability; in part this was due to smaller swab sizes and unlikely to be clinically relevant. Viral loads above 109 copies per swab were found in 8% of subjects, one-third of whom were PAMS, with a mean age of 37.6 years. We estimate 4.3 days from onset of shedding to peak viral load (108.1 RNA copies per swab) and peak cell culture isolation probability (0.75). B.1.1.7 subjects had mean log10 viral load 1.05 higher than that of non-B.1.1.7 subjects, and the estimated cell culture replication probability of B.1.1.7 subjects was higher by a factor of 2.6.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Asymptomatic Infections

KW - COVID-19/diagnosis

KW - COVID-19 Nucleic Acid Testing

KW - Caco-2 Cells

KW - Child

KW - Child, Preschool

KW - Female

KW - Germany

KW - Hospitalization

KW - Humans

KW - Infant

KW - Male

KW - Middle Aged

KW - Probability

KW - SARS-CoV-2/isolation & purification

KW - Viral Load

KW - Virus Replication

KW - Virus Shedding

KW - Young Adult

U2 - 10.1126/science.abi5273

DO - 10.1126/science.abi5273

M3 - SCORING: Journal article

C2 - 34035154

VL - 373

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6551

M1 - eabi5273

ER -