Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs)
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Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs) : A Population-Based Analysis. / Li, Yuqiang; Zhang, Guangfeng; Song, Xiangping; Zhao, Lilan; Güngör, Cenap; Wang, Dan; Liu, Wenxue; Huang, Yan; Tan, Fengbo.
In: Gastroenterology research and practice, Vol. 2020, 27.01.2020, p. 8493707.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs)
T2 - A Population-Based Analysis
AU - Li, Yuqiang
AU - Zhang, Guangfeng
AU - Song, Xiangping
AU - Zhao, Lilan
AU - Güngör, Cenap
AU - Wang, Dan
AU - Liu, Wenxue
AU - Huang, Yan
AU - Tan, Fengbo
N1 - Copyright © 2020 Yuqiang Li et al.
PY - 2020/1/27
Y1 - 2020/1/27
N2 - Aim: Assess the risk of synchronous metastasis and establish a nomogram in patients with GISTs.Methods: Surveillance, Epidemiology and End Results database (2004-2014) was accessed. With the logistic regression model as the basis, a nomogram was constructed.Results: 7,256 target patients were contained in our study. The nomogram discrimination for mGIST prediction revealed that tumor size contributed most to synchronous metastasis, followed by lymph nodes, extension, pathologic grade, tumor location, and mitotic count. C-index values of predictions were 0.821 (95% CI, 0.805-0.836) and 0.815 (95% CI, 0.800-0.831), and Brier score were 0.109 and 0.112 in training and validation group, respectively. The value of area under the ROCs were 0.813 (p < 0.001) in the primary cohort and 0.819 (p < 0.001) in the validation cohort. Through the calibration curves (as seen in the figures), nomogram prediction proved to have excellent agreement with actual metastatic diseases.Conclusion: A new nomogram was created that can evaluate synchronous metastatic diseases in patients with GISTs.
AB - Aim: Assess the risk of synchronous metastasis and establish a nomogram in patients with GISTs.Methods: Surveillance, Epidemiology and End Results database (2004-2014) was accessed. With the logistic regression model as the basis, a nomogram was constructed.Results: 7,256 target patients were contained in our study. The nomogram discrimination for mGIST prediction revealed that tumor size contributed most to synchronous metastasis, followed by lymph nodes, extension, pathologic grade, tumor location, and mitotic count. C-index values of predictions were 0.821 (95% CI, 0.805-0.836) and 0.815 (95% CI, 0.800-0.831), and Brier score were 0.109 and 0.112 in training and validation group, respectively. The value of area under the ROCs were 0.813 (p < 0.001) in the primary cohort and 0.819 (p < 0.001) in the validation cohort. Through the calibration curves (as seen in the figures), nomogram prediction proved to have excellent agreement with actual metastatic diseases.Conclusion: A new nomogram was created that can evaluate synchronous metastatic diseases in patients with GISTs.
U2 - 10.1155/2020/8493707
DO - 10.1155/2020/8493707
M3 - SCORING: Journal article
C2 - 32411204
VL - 2020
SP - 8493707
JO - GASTROENT RES PRACT
JF - GASTROENT RES PRACT
SN - 1687-6121
ER -
