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Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination.

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Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination. / Mack, D; Riedewald, J; Rohde, Holger; Magnus, T; Feucht, H H; Elsner, H A; Laufs, R; Rupp, M E.

In: INFECT IMMUN, Vol. 67, No. 2, 2, 1999, p. 1004-1008.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mack, D, Riedewald, J, Rohde, H, Magnus, T, Feucht, HH, Elsner, HA, Laufs, R & Rupp, ME 1999, 'Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination.', INFECT IMMUN, vol. 67, no. 2, 2, pp. 1004-1008. <http://www.ncbi.nlm.nih.gov/pubmed/9916125?dopt=Citation>

APA

Mack, D., Riedewald, J., Rohde, H., Magnus, T., Feucht, H. H., Elsner, H. A., Laufs, R., & Rupp, M. E. (1999). Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination. INFECT IMMUN, 67(2), 1004-1008. [2]. http://www.ncbi.nlm.nih.gov/pubmed/9916125?dopt=Citation

Vancouver

Mack D, Riedewald J, Rohde H, Magnus T, Feucht HH, Elsner HA et al. Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination. INFECT IMMUN. 1999;67(2):1004-1008. 2.

Bibtex

@article{6e07ee3e819841ee871cef47d8ba423a,
title = "Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination.",
abstract = "Hemagglutination of erythrocytes is a common property of Staphylococcus epidermidis strains, which is related to adherence and biofilm formation and may be essential for the pathogenesis of biomaterial-associated infections caused by S. epidermidis. In three independent biofilm-producing, hemagglutination-positive S. epidermidis isolates, interruption of the icaADBC operon essential for polysaccharide intercellular adhesin (PIA) synthesis by Tn917 insertions led to a hemagglutination-negative phenotype. An immunoglobulin G fraction of antiserum to PIA greatly reduced hemagglutination. Purified PIA led to a 64-fold decrease of hemagglutination titers of these strains; however, it did not mediate hemagglutination by itself. These observations define PIA as the hemagglutinin of S. epidermidis or at least as its major functional component.",
author = "D Mack and J Riedewald and Holger Rohde and T Magnus and Feucht, {H H} and Elsner, {H A} and R Laufs and Rupp, {M E}",
year = "1999",
language = "Deutsch",
volume = "67",
pages = "1004--1008",
journal = "INFECT IMMUN",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "2",

}

RIS

TY - JOUR

T1 - Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination.

AU - Mack, D

AU - Riedewald, J

AU - Rohde, Holger

AU - Magnus, T

AU - Feucht, H H

AU - Elsner, H A

AU - Laufs, R

AU - Rupp, M E

PY - 1999

Y1 - 1999

N2 - Hemagglutination of erythrocytes is a common property of Staphylococcus epidermidis strains, which is related to adherence and biofilm formation and may be essential for the pathogenesis of biomaterial-associated infections caused by S. epidermidis. In three independent biofilm-producing, hemagglutination-positive S. epidermidis isolates, interruption of the icaADBC operon essential for polysaccharide intercellular adhesin (PIA) synthesis by Tn917 insertions led to a hemagglutination-negative phenotype. An immunoglobulin G fraction of antiserum to PIA greatly reduced hemagglutination. Purified PIA led to a 64-fold decrease of hemagglutination titers of these strains; however, it did not mediate hemagglutination by itself. These observations define PIA as the hemagglutinin of S. epidermidis or at least as its major functional component.

AB - Hemagglutination of erythrocytes is a common property of Staphylococcus epidermidis strains, which is related to adherence and biofilm formation and may be essential for the pathogenesis of biomaterial-associated infections caused by S. epidermidis. In three independent biofilm-producing, hemagglutination-positive S. epidermidis isolates, interruption of the icaADBC operon essential for polysaccharide intercellular adhesin (PIA) synthesis by Tn917 insertions led to a hemagglutination-negative phenotype. An immunoglobulin G fraction of antiserum to PIA greatly reduced hemagglutination. Purified PIA led to a 64-fold decrease of hemagglutination titers of these strains; however, it did not mediate hemagglutination by itself. These observations define PIA as the hemagglutinin of S. epidermidis or at least as its major functional component.

M3 - SCORING: Zeitschriftenaufsatz

VL - 67

SP - 1004

EP - 1008

JO - INFECT IMMUN

JF - INFECT IMMUN

SN - 0019-9567

IS - 2

M1 - 2

ER -