Esomeprazole
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Esomeprazole : prevention and treatment of NSAID-induced symptoms and ulcers. / Morgner, Andrea; Miehlke, Stephan; Labenz, Joachim.
In: EXPERT OPIN PHARMACO, Vol. 8, No. 7, 05.2007, p. 975-88.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Esomeprazole
T2 - prevention and treatment of NSAID-induced symptoms and ulcers
AU - Morgner, Andrea
AU - Miehlke, Stephan
AU - Labenz, Joachim
PY - 2007/5
Y1 - 2007/5
N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most widely used drug classes. However, many patients complain of dyspeptic symptoms impairing their quality of life: ~ 20% of patients taking NSAIDs show endoscopic ulcers with or without symptoms, and up to 2% of chronic NSAID users will develop serious complications each year, such as bleeding or perforation, which are the cause of death in many patients. Coprescription of a proton pump inhibitor is one established option for the healing and prevention of NSAID-associated lesions of the upper gastrointestinal tract in patients at risk. Recent studies evaluated the clinical efficacy of esomeprazole in the management of gastrointestinal problems associated with the intake of selective and non-selective NSAIDs and aspirin.
AB - Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most widely used drug classes. However, many patients complain of dyspeptic symptoms impairing their quality of life: ~ 20% of patients taking NSAIDs show endoscopic ulcers with or without symptoms, and up to 2% of chronic NSAID users will develop serious complications each year, such as bleeding or perforation, which are the cause of death in many patients. Coprescription of a proton pump inhibitor is one established option for the healing and prevention of NSAID-associated lesions of the upper gastrointestinal tract in patients at risk. Recent studies evaluated the clinical efficacy of esomeprazole in the management of gastrointestinal problems associated with the intake of selective and non-selective NSAIDs and aspirin.
KW - Animals
KW - Anti-Inflammatory Agents, Non-Steroidal
KW - Anti-Ulcer Agents
KW - Dyspepsia
KW - Esomeprazole
KW - Humans
KW - Proton Pump Inhibitors
KW - Stomach Ulcer
KW - Journal Article
KW - Review
U2 - 10.1517/14656566.8.7.975
DO - 10.1517/14656566.8.7.975
M3 - SCORING: Journal article
C2 - 17472543
VL - 8
SP - 975
EP - 988
JO - EXPERT OPIN PHARMACO
JF - EXPERT OPIN PHARMACO
SN - 1465-6566
IS - 7
ER -