Research ExplorerPublicationserbB3 is dispensable for oligodendrocyte development in vitr...

erbB3 is dispensable for oligodendrocyte development in vitro and in vivo

Standard

erbB3 is dispensable for oligodendrocyte development in vitro and in vivo. / Schmucker, Johannes; Ader, Marius; Brockschnieder, Damian; Brodarac, Andreja; Bartsch, Udo; Riethmacher, Dieter.

In: GLIA, Vol. 44, No. 1, 10.2003, p. 67-75.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schmucker, J, Ader, M, Brockschnieder, D, Brodarac, A, Bartsch, U & Riethmacher, D 2003, 'erbB3 is dispensable for oligodendrocyte development in vitro and in vivo', GLIA, vol. 44, no. 1, pp. 67-75. https://doi.org/10.1002/glia.10275

APA

Schmucker, J., Ader, M., Brockschnieder, D., Brodarac, A., Bartsch, U., & Riethmacher, D. (2003). erbB3 is dispensable for oligodendrocyte development in vitro and in vivo. GLIA, 44(1), 67-75. https://doi.org/10.1002/glia.10275

Vancouver

Schmucker J, Ader M, Brockschnieder D, Brodarac A, Bartsch U, Riethmacher D. erbB3 is dispensable for oligodendrocyte development in vitro and in vivo. GLIA. 2003 Oct;44(1):67-75. https://doi.org/10.1002/glia.10275

Bibtex

@article{243ac6e5a5bd455e9540eb687f779297,
title = "erbB3 is dispensable for oligodendrocyte development in vitro and in vivo",
abstract = "During development and in the adult, erbB2, erbB3, and erbB4 are expressed in many tissues and as heterodimers (B2/B3, B2/B4) serve as receptors for neuregulins. The general importance of neuregulin receptors for development is underlined by the observed embryonic (erbB2, erbB4) or perinatal (erbB3) lethality in mouse mutants. These mutants further revealed the fundamental role of the erbB2/erbB3 heterodimer for proper Schwann cell development, the ensheathing glia of the peripheral nervous system. However, only little is known about the functions of neuregulins and their receptors during postnatal development and in the adult. erbB2 and erbB3 during late embryogenesis and postnatally are expressed in different areas and cell types of the central nervous system, including oligodendrocytes, the ensheathing glia of the central nervous system. As terminal differentiation of oligodendrocytes peaks during postnatal development, it is not possible to use the neuregulin receptor mouse mutants to study terminal differentiation of oligodendrocytes in their absence in vivo. In order to investigate possible functions of the erbB3 gene in oligodendrocytes, we employed two different techniques. First, we directed the differentiation of erbB3-deficient embryonic stem cells into neural cell types to analyze the development of oligodendrocytes in the absence of erbB3 in vitro. Second, we grafted neural stem cells from spinal cords of erbB3 mutants into the retina of young mice to monitor oligodendrocyte differentiation and myelination in vivo. Results of both experimental approaches clearly show that erbB3 is not required for normal oligodendrocyte development and myelination.",
keywords = "Animals, Animals, Newborn, Cell Differentiation, Cells, Cultured, Central Nervous System, Female, Fetus, Male, Mice, Mice, Mutant Strains, Microscopy, Electron, Myelin Sheath, Nerve Fibers, Myelinated, Neuregulins, Oligodendroglia, Receptor, ErbB-3, Retina, Spinal Cord, Stem Cells, Journal Article, Research Support, Non-U.S. Gov't",
author = "Johannes Schmucker and Marius Ader and Damian Brockschnieder and Andreja Brodarac and Udo Bartsch and Dieter Riethmacher",
note = "Copyright 2003 Wiley-Liss, Inc.",
year = "2003",
month = oct,
doi = "10.1002/glia.10275",
language = "English",
volume = "44",
pages = "67--75",
journal = "GLIA",
issn = "0894-1491",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - erbB3 is dispensable for oligodendrocyte development in vitro and in vivo

AU - Schmucker, Johannes

AU - Ader, Marius

AU - Brockschnieder, Damian

AU - Brodarac, Andreja

AU - Bartsch, Udo

AU - Riethmacher, Dieter

N1 - Copyright 2003 Wiley-Liss, Inc.

PY - 2003/10

Y1 - 2003/10

N2 - During development and in the adult, erbB2, erbB3, and erbB4 are expressed in many tissues and as heterodimers (B2/B3, B2/B4) serve as receptors for neuregulins. The general importance of neuregulin receptors for development is underlined by the observed embryonic (erbB2, erbB4) or perinatal (erbB3) lethality in mouse mutants. These mutants further revealed the fundamental role of the erbB2/erbB3 heterodimer for proper Schwann cell development, the ensheathing glia of the peripheral nervous system. However, only little is known about the functions of neuregulins and their receptors during postnatal development and in the adult. erbB2 and erbB3 during late embryogenesis and postnatally are expressed in different areas and cell types of the central nervous system, including oligodendrocytes, the ensheathing glia of the central nervous system. As terminal differentiation of oligodendrocytes peaks during postnatal development, it is not possible to use the neuregulin receptor mouse mutants to study terminal differentiation of oligodendrocytes in their absence in vivo. In order to investigate possible functions of the erbB3 gene in oligodendrocytes, we employed two different techniques. First, we directed the differentiation of erbB3-deficient embryonic stem cells into neural cell types to analyze the development of oligodendrocytes in the absence of erbB3 in vitro. Second, we grafted neural stem cells from spinal cords of erbB3 mutants into the retina of young mice to monitor oligodendrocyte differentiation and myelination in vivo. Results of both experimental approaches clearly show that erbB3 is not required for normal oligodendrocyte development and myelination.

AB - During development and in the adult, erbB2, erbB3, and erbB4 are expressed in many tissues and as heterodimers (B2/B3, B2/B4) serve as receptors for neuregulins. The general importance of neuregulin receptors for development is underlined by the observed embryonic (erbB2, erbB4) or perinatal (erbB3) lethality in mouse mutants. These mutants further revealed the fundamental role of the erbB2/erbB3 heterodimer for proper Schwann cell development, the ensheathing glia of the peripheral nervous system. However, only little is known about the functions of neuregulins and their receptors during postnatal development and in the adult. erbB2 and erbB3 during late embryogenesis and postnatally are expressed in different areas and cell types of the central nervous system, including oligodendrocytes, the ensheathing glia of the central nervous system. As terminal differentiation of oligodendrocytes peaks during postnatal development, it is not possible to use the neuregulin receptor mouse mutants to study terminal differentiation of oligodendrocytes in their absence in vivo. In order to investigate possible functions of the erbB3 gene in oligodendrocytes, we employed two different techniques. First, we directed the differentiation of erbB3-deficient embryonic stem cells into neural cell types to analyze the development of oligodendrocytes in the absence of erbB3 in vitro. Second, we grafted neural stem cells from spinal cords of erbB3 mutants into the retina of young mice to monitor oligodendrocyte differentiation and myelination in vivo. Results of both experimental approaches clearly show that erbB3 is not required for normal oligodendrocyte development and myelination.

KW - Animals

KW - Animals, Newborn

KW - Cell Differentiation

KW - Cells, Cultured

KW - Central Nervous System

KW - Female

KW - Fetus

KW - Male

KW - Mice

KW - Mice, Mutant Strains

KW - Microscopy, Electron

KW - Myelin Sheath

KW - Nerve Fibers, Myelinated

KW - Neuregulins

KW - Oligodendroglia

KW - Receptor, ErbB-3

KW - Retina

KW - Spinal Cord

KW - Stem Cells

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/glia.10275

DO - 10.1002/glia.10275

M3 - SCORING: Journal article

C2 - 12951658

VL - 44

SP - 67

EP - 75

JO - GLIA

JF - GLIA

SN - 0894-1491

IS - 1

ER -