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Epstein-Barr virus-associated diffuse large B-cell lymphoma of the hypopharynx

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Epstein-Barr virus-associated diffuse large B-cell lymphoma of the hypopharynx. / Cordes, C; Tiemann, M; Tiemann, K; Knappe, D; Hoffmann, M; Gottschlich, S.

In: B-ENT, Vol. 7, No. 1, 2011, p. 43-46.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Cordes, C, Tiemann, M, Tiemann, K, Knappe, D, Hoffmann, M & Gottschlich, S 2011, 'Epstein-Barr virus-associated diffuse large B-cell lymphoma of the hypopharynx', B-ENT, vol. 7, no. 1, pp. 43-46.

APA

Cordes, C., Tiemann, M., Tiemann, K., Knappe, D., Hoffmann, M., & Gottschlich, S. (2011). Epstein-Barr virus-associated diffuse large B-cell lymphoma of the hypopharynx. B-ENT, 7(1), 43-46.

Vancouver

Cordes C, Tiemann M, Tiemann K, Knappe D, Hoffmann M, Gottschlich S. Epstein-Barr virus-associated diffuse large B-cell lymphoma of the hypopharynx. B-ENT. 2011;7(1):43-46.

Bibtex

@article{59e9aa3b46b246ab97dfba3783bbfe4e,
title = "Epstein-Barr virus-associated diffuse large B-cell lymphoma of the hypopharynx",
abstract = "PROBLEMS/OBJECTIVES: Epstein-Barr virus (EBV) is commonly associated with nasopharyngeal carcinoma and Burkitt's lymphoma, but association with hypopharyngeal and laryngeal tumours is rare. To the best of our knowledge, this is the first case report of an EBV-associated diffuse large B-cell lymphoma (DLBCL) of the hypopharynx.METHODOLOGY: A 63-year-old male patient suffering from chronic lymphocytic leukemia presented with swallowing disorders and a sore throat. Panendoscopy with laser surgical resection of tissue specimens was performed.RESULTS: Immunohistochemical and molecular genetic diagnostics, including EBV-encoded small RNA in situ hybridization, confirmed the diagnosis of an EBV-associated DLBCL of the hypopharynx. Ten weeks after the diagnosis, the patient died of disease related to multiple complications.CONCLUSIONS: We hypothesize that the EBV infection was triggered by long-term immunosuppressive therapy that led secondarily to the development of a DLBCL. Otorhinolaryngologists should keep in mind that lymphomas might develop in the entire pharynx.",
keywords = "Epstein-Barr Virus Infections/complications, Fatal Outcome, Humans, Hypopharyngeal Neoplasms/diagnostic imaging, Immunocompromised Host, Immunohistochemistry, Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy, Lymphoma, Large B-Cell, Diffuse/diagnostic imaging, Male, Middle Aged, Pyriform Sinus/virology, Tomography, X-Ray Computed",
author = "C Cordes and M Tiemann and K Tiemann and D Knappe and M Hoffmann and S Gottschlich",
year = "2011",
language = "English",
volume = "7",
pages = "43--46",
journal = "B-ENT",
issn = "1781-782X",
publisher = "Koninklijke Belgische Vereniging voor ORL Gelaat en Halschirugie",
number = "1",

}

RIS

TY - JOUR

T1 - Epstein-Barr virus-associated diffuse large B-cell lymphoma of the hypopharynx

AU - Cordes, C

AU - Tiemann, M

AU - Tiemann, K

AU - Knappe, D

AU - Hoffmann, M

AU - Gottschlich, S

PY - 2011

Y1 - 2011

N2 - PROBLEMS/OBJECTIVES: Epstein-Barr virus (EBV) is commonly associated with nasopharyngeal carcinoma and Burkitt's lymphoma, but association with hypopharyngeal and laryngeal tumours is rare. To the best of our knowledge, this is the first case report of an EBV-associated diffuse large B-cell lymphoma (DLBCL) of the hypopharynx.METHODOLOGY: A 63-year-old male patient suffering from chronic lymphocytic leukemia presented with swallowing disorders and a sore throat. Panendoscopy with laser surgical resection of tissue specimens was performed.RESULTS: Immunohistochemical and molecular genetic diagnostics, including EBV-encoded small RNA in situ hybridization, confirmed the diagnosis of an EBV-associated DLBCL of the hypopharynx. Ten weeks after the diagnosis, the patient died of disease related to multiple complications.CONCLUSIONS: We hypothesize that the EBV infection was triggered by long-term immunosuppressive therapy that led secondarily to the development of a DLBCL. Otorhinolaryngologists should keep in mind that lymphomas might develop in the entire pharynx.

AB - PROBLEMS/OBJECTIVES: Epstein-Barr virus (EBV) is commonly associated with nasopharyngeal carcinoma and Burkitt's lymphoma, but association with hypopharyngeal and laryngeal tumours is rare. To the best of our knowledge, this is the first case report of an EBV-associated diffuse large B-cell lymphoma (DLBCL) of the hypopharynx.METHODOLOGY: A 63-year-old male patient suffering from chronic lymphocytic leukemia presented with swallowing disorders and a sore throat. Panendoscopy with laser surgical resection of tissue specimens was performed.RESULTS: Immunohistochemical and molecular genetic diagnostics, including EBV-encoded small RNA in situ hybridization, confirmed the diagnosis of an EBV-associated DLBCL of the hypopharynx. Ten weeks after the diagnosis, the patient died of disease related to multiple complications.CONCLUSIONS: We hypothesize that the EBV infection was triggered by long-term immunosuppressive therapy that led secondarily to the development of a DLBCL. Otorhinolaryngologists should keep in mind that lymphomas might develop in the entire pharynx.

KW - Epstein-Barr Virus Infections/complications

KW - Fatal Outcome

KW - Humans

KW - Hypopharyngeal Neoplasms/diagnostic imaging

KW - Immunocompromised Host

KW - Immunohistochemistry

KW - Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy

KW - Lymphoma, Large B-Cell, Diffuse/diagnostic imaging

KW - Male

KW - Middle Aged

KW - Pyriform Sinus/virology

KW - Tomography, X-Ray Computed

M3 - SCORING: Journal article

C2 - 21563556

VL - 7

SP - 43

EP - 46

JO - B-ENT

JF - B-ENT

SN - 1781-782X

IS - 1

ER -