Epithelial cell adhesion molecule is an independent prognostic marker in clear cell renal carcinoma.
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Epithelial cell adhesion molecule is an independent prognostic marker in clear cell renal carcinoma. / Eichelberg, Christian; Chun, Felix; Bedke, Jens; Heuer, Roman; Adam, Meike; Moch, Holger; Terracciano, Luigi; Hinrichs, Kristin; Dahlem, Roland; Fisch, Margit; Schlomm, Thorsten; Sauter, Guido; Minner, Sarah Jane Pauline.
In: INT J CANCER, Vol. 132, No. 12, 12, 2013, p. 2948-2955.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Epithelial cell adhesion molecule is an independent prognostic marker in clear cell renal carcinoma.
AU - Eichelberg, Christian
AU - Chun, Felix
AU - Bedke, Jens
AU - Heuer, Roman
AU - Adam, Meike
AU - Moch, Holger
AU - Terracciano, Luigi
AU - Hinrichs, Kristin
AU - Dahlem, Roland
AU - Fisch, Margit
AU - Schlomm, Thorsten
AU - Sauter, Guido
AU - Minner, Sarah Jane Pauline
PY - 2013
Y1 - 2013
N2 - Epithelial cell adhesion molecule (EPCAM) has recently attained a renewed interest as a candidate protein in diagnosis, prognostication and therapy of various tumor entities. The molecular epidemiology and prognostic relevance of EPCAM in renal cell carcinoma (RCC) and amongst the histological subtypes of RCC are unclear. We analyzed the prevalence and prognostic significance of EPCAM in a tumor tissue microarray composed of 1,088 independent RCCs samples by immunohistochemistry (IHC). We found significant variations of EPCAM IHC staining intensities in between the RCC subtypes: in papillary and chromophobe RCC, the majority of tumors (89-93%) showed an at least weak EPCAM protein expression. In the largest subgroup, the clear cell (cc)RCC (n = 767), a negative EPCAM IHC was found in 1/3 of the patients and was associated with high-grade disease and nodal metastases. Kaplan-Meier analyses demonstrated a significant association between positive EPCAM IHC and prolonged overall survival, even in a subset of low-risk ccRCC. In multivariable analyses, EPCAM represented an independent risk factor of survival throughout all subgroups. For localized, low-grade ccRCC, information of EPCAM IHC raised predictive accuracy of a multivariate model by ?5%, compared to T-stage and grade alone. Our findings indicate that EPCAM is an independent prognostic molecular marker in ccRCC and, especially in localized ccRCC, might be able to provide auxiliary information for a better prognostication.
AB - Epithelial cell adhesion molecule (EPCAM) has recently attained a renewed interest as a candidate protein in diagnosis, prognostication and therapy of various tumor entities. The molecular epidemiology and prognostic relevance of EPCAM in renal cell carcinoma (RCC) and amongst the histological subtypes of RCC are unclear. We analyzed the prevalence and prognostic significance of EPCAM in a tumor tissue microarray composed of 1,088 independent RCCs samples by immunohistochemistry (IHC). We found significant variations of EPCAM IHC staining intensities in between the RCC subtypes: in papillary and chromophobe RCC, the majority of tumors (89-93%) showed an at least weak EPCAM protein expression. In the largest subgroup, the clear cell (cc)RCC (n = 767), a negative EPCAM IHC was found in 1/3 of the patients and was associated with high-grade disease and nodal metastases. Kaplan-Meier analyses demonstrated a significant association between positive EPCAM IHC and prolonged overall survival, even in a subset of low-risk ccRCC. In multivariable analyses, EPCAM represented an independent risk factor of survival throughout all subgroups. For localized, low-grade ccRCC, information of EPCAM IHC raised predictive accuracy of a multivariate model by ?5%, compared to T-stage and grade alone. Our findings indicate that EPCAM is an independent prognostic molecular marker in ccRCC and, especially in localized ccRCC, might be able to provide auxiliary information for a better prognostication.
KW - Humans
KW - Cohort Studies
KW - Prognosis
KW - Survival Analysis
KW - Prevalence
KW - Risk
KW - Tumor Markers, Biological/metabolism
KW - Cell Adhesion Molecules/metabolism
KW - Europe/epidemiology
KW - Antigens, Neoplasm/metabolism
KW - Carcinoma, Renal Cell/diagnosis/epidemiology/metabolism
KW - Humans
KW - Cohort Studies
KW - Prognosis
KW - Survival Analysis
KW - Prevalence
KW - Risk
KW - Tumor Markers, Biological/metabolism
KW - Cell Adhesion Molecules/metabolism
KW - Europe/epidemiology
KW - Antigens, Neoplasm/metabolism
KW - Carcinoma, Renal Cell/diagnosis/epidemiology/metabolism
M3 - SCORING: Journal article
VL - 132
SP - 2948
EP - 2955
JO - INT J CANCER
JF - INT J CANCER
SN - 0020-7136
IS - 12
M1 - 12
ER -
