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Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors

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Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. / Thomas, Christian; Metrock, Katie; Kordes, Uwe; Hasselblatt, Martin; Dhall, Girish.

In: J NEURO-ONCOL, Vol. 148, No. 1, 05.2020, p. 39-45.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Thomas, C, Metrock, K, Kordes, U, Hasselblatt, M & Dhall, G 2020, 'Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors', J NEURO-ONCOL, vol. 148, no. 1, pp. 39-45. https://doi.org/10.1007/s11060-020-03509-5

APA

Thomas, C., Metrock, K., Kordes, U., Hasselblatt, M., & Dhall, G. (2020). Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. J NEURO-ONCOL, 148(1), 39-45. https://doi.org/10.1007/s11060-020-03509-5

Vancouver

Thomas C, Metrock K, Kordes U, Hasselblatt M, Dhall G. Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. J NEURO-ONCOL. 2020 May;148(1):39-45. https://doi.org/10.1007/s11060-020-03509-5

Bibtex

@article{42dbef835c6946d8b1ee4c8c8d5b6150,
title = "Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors",
abstract = "PURPOSE: Choroid plexus tumors comprise of choroid plexus papilloma (CPP, WHO grade I), atypical choroid plexus papilloma (aCPP, WHO grade II) and choroid plexus carcinoma (CPC, WHO grade III). Molecular events driving the majority of choroid plexus tumors remain poorly understood. Recently, DNA methylation profiling has revealed different epigenetic subgroups.METHODS: Comprehensive review of epigenetic profiles of choroid plexus tumors in the context of histopathological, genetic, and clinical features. DNA methylation profiling segregates choroid plexus tumors into three distinct epigenetic subgroups: supratentorial pediatric low-risk choroid plexus tumors (CPP and aCPP), infratentorial adult low-risk choroid plexus tumors (CPP and aCPP), and supratentorial pediatric high-risk choroid plexus tumors (CPP and aCPP and CPC). Epigenetic subgrouping provides additional prognostic information in comparison to histopathological grading.CONCLUSIONS: Epigenetic profiling of choroid plexus tumors can be used for the identification of patients at risk of recurrence and is expected to play a role for treatment stratification and patient management in the context of future clinical trials.",
author = "Christian Thomas and Katie Metrock and Uwe Kordes and Martin Hasselblatt and Girish Dhall",
year = "2020",
month = may,
doi = "10.1007/s11060-020-03509-5",
language = "English",
volume = "148",
pages = "39--45",
journal = "J NEURO-ONCOL",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "1",

}

RIS

TY - JOUR

T1 - Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors

AU - Thomas, Christian

AU - Metrock, Katie

AU - Kordes, Uwe

AU - Hasselblatt, Martin

AU - Dhall, Girish

PY - 2020/5

Y1 - 2020/5

N2 - PURPOSE: Choroid plexus tumors comprise of choroid plexus papilloma (CPP, WHO grade I), atypical choroid plexus papilloma (aCPP, WHO grade II) and choroid plexus carcinoma (CPC, WHO grade III). Molecular events driving the majority of choroid plexus tumors remain poorly understood. Recently, DNA methylation profiling has revealed different epigenetic subgroups.METHODS: Comprehensive review of epigenetic profiles of choroid plexus tumors in the context of histopathological, genetic, and clinical features. DNA methylation profiling segregates choroid plexus tumors into three distinct epigenetic subgroups: supratentorial pediatric low-risk choroid plexus tumors (CPP and aCPP), infratentorial adult low-risk choroid plexus tumors (CPP and aCPP), and supratentorial pediatric high-risk choroid plexus tumors (CPP and aCPP and CPC). Epigenetic subgrouping provides additional prognostic information in comparison to histopathological grading.CONCLUSIONS: Epigenetic profiling of choroid plexus tumors can be used for the identification of patients at risk of recurrence and is expected to play a role for treatment stratification and patient management in the context of future clinical trials.

AB - PURPOSE: Choroid plexus tumors comprise of choroid plexus papilloma (CPP, WHO grade I), atypical choroid plexus papilloma (aCPP, WHO grade II) and choroid plexus carcinoma (CPC, WHO grade III). Molecular events driving the majority of choroid plexus tumors remain poorly understood. Recently, DNA methylation profiling has revealed different epigenetic subgroups.METHODS: Comprehensive review of epigenetic profiles of choroid plexus tumors in the context of histopathological, genetic, and clinical features. DNA methylation profiling segregates choroid plexus tumors into three distinct epigenetic subgroups: supratentorial pediatric low-risk choroid plexus tumors (CPP and aCPP), infratentorial adult low-risk choroid plexus tumors (CPP and aCPP), and supratentorial pediatric high-risk choroid plexus tumors (CPP and aCPP and CPC). Epigenetic subgrouping provides additional prognostic information in comparison to histopathological grading.CONCLUSIONS: Epigenetic profiling of choroid plexus tumors can be used for the identification of patients at risk of recurrence and is expected to play a role for treatment stratification and patient management in the context of future clinical trials.

U2 - 10.1007/s11060-020-03509-5

DO - 10.1007/s11060-020-03509-5

M3 - SCORING: Review article

C2 - 32342334

VL - 148

SP - 39

EP - 45

JO - J NEURO-ONCOL

JF - J NEURO-ONCOL

SN - 0167-594X

IS - 1

ER -