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Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?

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Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? / Kaminski, Jakob A; Schlagenhauf, Florian; Rapp, Michael; Awasthi, Swapnil; Ruggeri, Barbara; Deserno, Lorenz; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Smolka, Michael N; Fröhner, Juliane H; Walter, Henrik; Whelan, Robert; Ripke, Stephan; Schumann, Gunter; Heinz, Andreas; IMAGEN Consortium.

In: TRANSL PSYCHIAT, Vol. 8, No. 1, 30.08.2018, p. 169.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kaminski, JA, Schlagenhauf, F, Rapp, M, Awasthi, S, Ruggeri, B, Deserno, L, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Quinlan, EB, Desrivières, S, Flor, H, Frouin, V, Garavan, H, Gowland, P, Ittermann, B, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Smolka, MN, Fröhner, JH, Walter, H, Whelan, R, Ripke, S, Schumann, G, Heinz, A & IMAGEN Consortium 2018, 'Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?', TRANSL PSYCHIAT, vol. 8, no. 1, pp. 169. https://doi.org/10.1038/s41398-018-0222-7

APA

Kaminski, J. A., Schlagenhauf, F., Rapp, M., Awasthi, S., Ruggeri, B., Deserno, L., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Ittermann, B., Martinot, J-L., Martinot, M-L. P., ... IMAGEN Consortium (2018). Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? TRANSL PSYCHIAT, 8(1), 169. https://doi.org/10.1038/s41398-018-0222-7

Vancouver

Kaminski JA, Schlagenhauf F, Rapp M, Awasthi S, Ruggeri B, Deserno L et al. Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? TRANSL PSYCHIAT. 2018 Aug 30;8(1):169. https://doi.org/10.1038/s41398-018-0222-7

Bibtex

@article{4987fc0434e94f6fa7847216989298cc,
title = "Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?",
abstract = "Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the {"}missing heritability{"} between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.",
keywords = "Adolescent, Corpus Striatum/anatomy & histology, Dopamine/physiology, Epigenesis, Genetic, Female, Humans, Intelligence/genetics, Intelligence Tests, Male, Receptors, Dopamine D2/genetics",
author = "Kaminski, {Jakob A} and Florian Schlagenhauf and Michael Rapp and Swapnil Awasthi and Barbara Ruggeri and Lorenz Deserno and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin Burke} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Hugh Garavan and Penny Gowland and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Smolka, {Michael N} and Fr{\"o}hner, {Juliane H} and Henrik Walter and Robert Whelan and Stephan Ripke and Gunter Schumann and Andreas Heinz and {IMAGEN Consortium}",
year = "2018",
month = aug,
day = "30",
doi = "10.1038/s41398-018-0222-7",
language = "English",
volume = "8",
pages = "169",
journal = "TRANSL PSYCHIAT",
issn = "2158-3188",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?

AU - Kaminski, Jakob A

AU - Schlagenhauf, Florian

AU - Rapp, Michael

AU - Awasthi, Swapnil

AU - Ruggeri, Barbara

AU - Deserno, Lorenz

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Fröhner, Juliane H

AU - Walter, Henrik

AU - Whelan, Robert

AU - Ripke, Stephan

AU - Schumann, Gunter

AU - Heinz, Andreas

AU - IMAGEN Consortium

PY - 2018/8/30

Y1 - 2018/8/30

N2 - Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.

AB - Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.

KW - Adolescent

KW - Corpus Striatum/anatomy & histology

KW - Dopamine/physiology

KW - Epigenesis, Genetic

KW - Female

KW - Humans

KW - Intelligence/genetics

KW - Intelligence Tests

KW - Male

KW - Receptors, Dopamine D2/genetics

U2 - 10.1038/s41398-018-0222-7

DO - 10.1038/s41398-018-0222-7

M3 - SCORING: Journal article

C2 - 30166545

VL - 8

SP - 169

JO - TRANSL PSYCHIAT

JF - TRANSL PSYCHIAT

SN - 2158-3188

IS - 1

ER -