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Epidermal tight junctions in health and disease

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Epidermal tight junctions in health and disease. / Brandner, J M; Zorn-Kruppa, M; Yoshida, T; Moll, I; Beck, L A; De Benedetto, A.

In: TISSUE BARRIERS, Vol. 3, No. 1-2, 01.01.2015, p. e974451.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brandner, JM, Zorn-Kruppa, M, Yoshida, T, Moll, I, Beck, LA & De Benedetto, A 2015, 'Epidermal tight junctions in health and disease', TISSUE BARRIERS, vol. 3, no. 1-2, pp. e974451. https://doi.org/10.4161/21688370.2014.974451

APA

Brandner, J. M., Zorn-Kruppa, M., Yoshida, T., Moll, I., Beck, L. A., & De Benedetto, A. (2015). Epidermal tight junctions in health and disease. TISSUE BARRIERS, 3(1-2), e974451. https://doi.org/10.4161/21688370.2014.974451

Vancouver

Brandner JM, Zorn-Kruppa M, Yoshida T, Moll I, Beck LA, De Benedetto A. Epidermal tight junctions in health and disease. TISSUE BARRIERS. 2015 Jan 1;3(1-2):e974451. https://doi.org/10.4161/21688370.2014.974451

Bibtex

@article{b5a600c566364964aa944f4867764bd6,
title = "Epidermal tight junctions in health and disease",
abstract = "The skin, the largest organ of the body, is an essential barrier that under homeostatic conditions efficiently protects and/or minimizes damage from both environmental (e.g. microorganisms, physical trauma, ultraviolet radiation) and endogenous (e.g., cancers, inflammation) factors. This formidable barrier function resides mainly in the epidermis, a dynamic, highly-stratified epithelium. The epidermis has 2 major barrier structures: stratum corneum, the outmost layer and tight junctions, intercellular junctions that seal adjacent keratinocytes in the stratum granulosum, found below the stratum corneum. In recent years there have been significant advances in our understanding of tight junction function, composition and regulation. Herein we review what is known about tight junctions in healthy skin and keratinocyte culture systems and highlight the dynamic crosstalk observed between tight junctions and the cutaneous immune system. Finally we discuss the preliminary observations suggesting that tight junction function or protein expression may be relevant for the pathogenesis of a number of common cutaneous inflammatory and neoplastic conditions.",
author = "Brandner, {J M} and M Zorn-Kruppa and T Yoshida and I Moll and Beck, {L A} and {De Benedetto}, A",
year = "2015",
month = jan,
day = "1",
doi = "10.4161/21688370.2014.974451",
language = "English",
volume = "3",
pages = "e974451",
journal = "TISSUE BARRIERS",
issn = "2168-8370",
publisher = "Taylor and Francis Ltd.",
number = "1-2",

}

RIS

TY - JOUR

T1 - Epidermal tight junctions in health and disease

AU - Brandner, J M

AU - Zorn-Kruppa, M

AU - Yoshida, T

AU - Moll, I

AU - Beck, L A

AU - De Benedetto, A

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The skin, the largest organ of the body, is an essential barrier that under homeostatic conditions efficiently protects and/or minimizes damage from both environmental (e.g. microorganisms, physical trauma, ultraviolet radiation) and endogenous (e.g., cancers, inflammation) factors. This formidable barrier function resides mainly in the epidermis, a dynamic, highly-stratified epithelium. The epidermis has 2 major barrier structures: stratum corneum, the outmost layer and tight junctions, intercellular junctions that seal adjacent keratinocytes in the stratum granulosum, found below the stratum corneum. In recent years there have been significant advances in our understanding of tight junction function, composition and regulation. Herein we review what is known about tight junctions in healthy skin and keratinocyte culture systems and highlight the dynamic crosstalk observed between tight junctions and the cutaneous immune system. Finally we discuss the preliminary observations suggesting that tight junction function or protein expression may be relevant for the pathogenesis of a number of common cutaneous inflammatory and neoplastic conditions.

AB - The skin, the largest organ of the body, is an essential barrier that under homeostatic conditions efficiently protects and/or minimizes damage from both environmental (e.g. microorganisms, physical trauma, ultraviolet radiation) and endogenous (e.g., cancers, inflammation) factors. This formidable barrier function resides mainly in the epidermis, a dynamic, highly-stratified epithelium. The epidermis has 2 major barrier structures: stratum corneum, the outmost layer and tight junctions, intercellular junctions that seal adjacent keratinocytes in the stratum granulosum, found below the stratum corneum. In recent years there have been significant advances in our understanding of tight junction function, composition and regulation. Herein we review what is known about tight junctions in healthy skin and keratinocyte culture systems and highlight the dynamic crosstalk observed between tight junctions and the cutaneous immune system. Finally we discuss the preliminary observations suggesting that tight junction function or protein expression may be relevant for the pathogenesis of a number of common cutaneous inflammatory and neoplastic conditions.

U2 - 10.4161/21688370.2014.974451

DO - 10.4161/21688370.2014.974451

M3 - SCORING: Journal article

C2 - 25838981

VL - 3

SP - e974451

JO - TISSUE BARRIERS

JF - TISSUE BARRIERS

SN - 2168-8370

IS - 1-2

ER -